Theory and Simulation of Texture Transformations in Chiral Systems: Applications to Biological Fibrous Composites

2001 ◽  
Vol 709 ◽  
Author(s):  
Gino De Luca ◽  
Alejandro D. Rey

ABSTRACTNumerous studies [1-3] have shown that chiral biological structures share common properties with liquids crystals, in particular a tendency to assemble in three-dimensional lattices very similar to that of chiral nematics. Biological fibrous composites are usually found in planar (film) and cylindrical (fibber) twist geometries. In this work, the formation process of the planar twist architecture is numerically investigated using a mesoscopic model based on the Landau-de Gennes theory of chiral nematic liquid crystals. The simulations and visualizations of the computed textures provide new information on some of the principles that govern the formation of chiral biological structures. It is found that a defect-free planar twist architecture arises from a chiral front propagation process with a fully relaxed wake.

1993 ◽  
Vol 265 (6) ◽  
pp. L521-L548 ◽  
Author(s):  
R. P. Bolender ◽  
D. M. Hyde ◽  
R. T. Dehoff

Today all structural information of the lung can be quantified and interpreted in the three-dimensional space of real-world biology. Remarkable achievements in the theory and practice of biological stereology are creating a new generation of data suitable for constructing structural hierarchies. Such hierarchies serve to organize and link biological data, thereby providing a framework on which to build new information systems. In this review, we describe the new tools of quantitative morphology and show how they can be used to design new experiments for lung research.


2021 ◽  
Author(s):  
Chenxi Qian ◽  
Kun Miao ◽  
Li-En Lin ◽  
Xinhong Chen ◽  
Jiajun Du ◽  
...  

Innovations in high-resolution optical imaging have allowed visualization of nanoscale biological structures and connections. However, super-resolution fluorescence techniques, including both optics-oriented and sample-expansion based, are limited in quantification and throughput especially in tissues from photobleaching or quenching of the fluorophores, and low-efficiency or non-uniform delivery of the probes. Here, we report a general sample-expansion vibrational imaging strategy, termed VISTA, for scalable label-free high-resolution interrogations of protein-rich biological structures with resolution down to 82 nm. VISTA achieves decent three-dimensional image quality through optimal retention of endogenous proteins, isotropic sample expansion, and deprivation of scattering lipids. Free from probe-labeling associated issues, VISTA offers unbiased and high-throughput tissue investigations. With correlative VISTA and immunofluorescence, we further validated the imaging specificity of VISTA and trained an image-segmentation model for label-free multi-component and volumetric prediction of nucleus, blood vessels, neuronal cells and dendrites in complex mouse brain tissues. VISTA could hence open new avenues for versatile biomedical studies.


Over most of each active region in nematic and chiral nematic twist cells the motion and configuration of the liquid crystal layer does not vary appreciably with position parallel to the surfaces. In such laminar regions the statics, dynamics and optics ot the cell can be accurately simulated at low cost on a computer of moderate size, given the appropriate physical parameters. Methods and recent advances in simulation of laminar regions are reviewed. Bistable twist cells are simulated for illustration. Important problems of stability and edge effects in the presence of electric fields await solution with two- or three-dimensional simulations.


2018 ◽  
Vol 97 (3) ◽  
Author(s):  
Minh Doan ◽  
J. J. Simons ◽  
Katherine Lilienthal ◽  
Tom Solomon ◽  
Kevin A. Mitchell

1987 ◽  
Vol 24 (4) ◽  
pp. 796-805 ◽  
Author(s):  
Stephen J. Godfrey ◽  
Anthony R. Fiorillo ◽  
Robert L. Carroll

A virtually complete three-dimensional skull of a subadult of the temnospondyl amphibian Dendrerpeton acadianum provides new information on the structure of the palate and lower jaw. The left stapes appears to lie in a natural position on the quadrate ramus of the pterygoid. The proportionately large otic ossicle probably precluded it from having acted as a transmitter of airborne vibrations from a tympanum to the inner ear. The use of the term "otic notch" should be restricted to amphibians or reptiles in which the embayment of the posterior margin of the cheek is accompanied by the presence of a slender rod-like stapes that could have functioned as part of an impedance matching system. In those species in which a notch is present but the stapes is a massive "supporting" element, the term "squamosal embayment" should be used, rather than "otic notch." The squamosal embayment in early tetrapods may have been inherited directly from their fish ancestors and had no functional relationship to hearing.


2016 ◽  
Vol 314 ◽  
pp. 18-34 ◽  
Author(s):  
Giacomo Canevari ◽  
Mythily Ramaswamy ◽  
Apala Majumdar

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