Correlated Single Molecule Fluorescence and Scanning Probe Microscopies: Applications to the Study of Soft Materials

2004 ◽  
Vol 844 ◽  
Author(s):  
Andrea L. Slade ◽  
James E. Shaw ◽  
Guocheng Yang ◽  
Neetu Chhabra ◽  
Christopher M. Yip
Keyword(s):  
Structure Function ◽  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Evanescent Wave ◽  
Soft Materials ◽  
Scanning Probe ◽  
Single Molecule Fluorescence ◽  
Lipid Films ◽  
Imaging And Spectroscopy

AbstractWe recently developed an integrated imaging platform that combines single molecule evanescent wave fluorescence imaging (and spectroscopy) with in situ scanning probe microscopy. The advantages, challenges, and potential represented by this coupled tool will be described in the context of the structure-function characteristics of nanostructured biomaterials and thin lipid films.

Correlated Single Molecule Fluorescence and Scanning Probe Microscopies: Applications to the Study of Soft Materials

2004 ◽  
Vol 841 ◽  
Author(s):  
Andrea L. Slade ◽  
James E. Shaw ◽  
Guocheng Yang ◽  
Neetu Chhabra ◽  
Christopher M. Yip
Keyword(s):  
Structure Function ◽  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Evanescent Wave ◽  
Soft Materials ◽  
Scanning Probe ◽  
Single Molecule Fluorescence ◽  
Lipid Films ◽  
Imaging And Spectroscopy

ABSTRACTWe recently developed an integrated imaging platform that combines single molecule evanescent wave fluorescence imaging (and spectroscopy) with in situ scanning probe microscopy. The advantages, challenges, and potential represented by this coupled tool will be described in the context of the structure-function characteristics of nanostructured biomaterials and thin lipid films.

Developments in Using Scanning Probe Microscopy To Study Molecules on Surfaces — From Thin Films and Single-Molecule Conductivity to Drug–Living Cell Interactions

2006 ◽  
Vol 59 (6) ◽  
pp. 359 ◽  
Author(s):  
Pall Thordarson ◽  
Rob Atkin ◽  
Wouter H. J. Kalle ◽  
Gregory G. Warr ◽  
Filip Braet
Keyword(s):  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Cell Interactions ◽  
Scanning Probe ◽  
Probe Microscopy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Tunnelling Microscopy ◽  
Molecule Surface

Scanning probe microscopy (SPM) techniques, including atomic force microscopy (AFM) and scanning tunnelling microscopy (STM), have revolutionized our understanding of molecule–surface interactions. The high resolution and versatility of SPM techniques have helped elucidate the morphology of adsorbed surfactant layers, facilitated the study of electronically conductive single molecules and biomolecules connected to metal substrates, and allowed direct observation of real-time processes such as in situ DNA hybridization and drug–cell interactions. These examples illustrate the power that SPM possesses to study (bio)molecules on surfaces and will be discussed in depth in this review.

Coupling evanescent-wave fluorescence imaging and spectroscopy with scanning probe microscopy: challenges and insights from TIRF–AFM

2006 ◽  
Vol 38 (11) ◽  
pp. 1459-1471 ◽  
Author(s):  
James E. Shaw ◽  
John Oreopoulos ◽  
Daniel Wong ◽  
Jenny C. Y. Hsu ◽  
Christopher M. Yip
Keyword(s):  
Fluorescence Imaging ◽  
Scanning Probe Microscopy ◽  
Evanescent Wave ◽  
Scanning Probe ◽  
Probe Microscopy ◽  
Imaging And Spectroscopy

Cationic Polyacrylamide Conformation on Mica Studied by Single Molecule “Pulling” with Scanning Probe Microscopy

2007 ◽  
Vol 40 (13) ◽  
pp. 4561-4567 ◽  
Author(s):  
Brett Brotherson ◽  
Lawrence A. Bottomley ◽  
Peter Ludovice ◽  
Yulin Deng
Keyword(s):  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Probe Microscopy ◽  
Cationic Polyacrylamide

Anisotropic acoustic phonon polariton-enhanced infrared spectroscopy for single molecule detection

Nanoscale ◽  
2021 ◽  
Author(s):  
wei Lv ◽  
hanchao Teng ◽  
chenchen Wu ◽  
Xiaotao Zhang ◽  
Xiangdong Guo ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Acoustic Phonon ◽  
Fourier Transforms ◽  
High Spatial Resolution ◽  
Scanning Probe ◽  
Surface Species ◽  
Composition And Structure ◽  
Fourier Transforms Infrared Spectroscopy

Nanoscale Fourier transforms infrared spectroscopy (nano-FTIR) based on scanning probe microscopy enables identification of chemical composition and structure of surface species with a high spatial resolution (~10 nm), which is...

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