Protozoynye invasion of urogenital system in combine with bacterial vaginosis agents by women of fertil age and their sexual partners

2018 ◽  
pp. 100-106
Author(s):  
P.V. Fedorich ◽  

Study of protozoyny invazions of the uroganital system with combination of microorganisms which are associated with bacterial vaginosis by women of fertil age and their sexual partners men is perspective direction of modern medicine. The development of this direction can increase the level of diagnostic inspection of patients by transmissible mainly sexual way infections and improve of efficiency of their treatment. The objective: exposure of combine defeats of uroganital system with different kinds of trichomonas or lamblias and microorganisms which are associated with bacterial vaginosis, for the women of fertil age and their sexual partners – men. All patients have infections, transmissible mainly sexual way with a chronic process and their treatment. Materials and methods. The special research of biomaterial, taken from the urogenital system of women of fertil age and their sexual partners-men, patients infections, transmissible mainly sexual way with a chronic process is conducted. 198 patients were inspected in clinic. Used the method of PCR, amplifier of DT-96, reagents of «Femoflor-16», praymeris for the indication of Trichomonas vaginalis, Trichomonas tenax, Pentatrichomonas hominis and Giardia lamblia. Results. Protozoyny invasions of the urogenital system determined at 88 (44.4%) of patients. At 77 (38.8%) from them determined the differet kinds of trichomonadies: Trichomonas tenax – at 41 (20.7%), Pentatrichomonas hominis – at 28 (14.1%), Trichomonas vaginalis – at 8 (4%). Giardia lamblia determined from 11 patients (5.6%). For 92% inspected patients with a protozoal invasions were determined the increassng of indexes of microflora, associated with bacterial vaginosis. The treatment of combine pathology of urogenital system which are caused different kinds trichomonades and microorganisms, which associated with BV, were conducted with etiotropic therapy. Seknidox used 2 tablets one time per day during 5 days. Orcipol used 1 tablets 3 or 2 times per a day (depending on weight) during 10 days. In research took part 56 patients with chronic ITSW. By 54 patients (96.4%) were eliminated of trichomonas. The normalization microflora’s level is attained for a 31 (57.4%) patient. Decrease of mocroflora’s, which associated with BV is marked by 24 patients (42.6%). Conclusions. This original method of treatment, is effective, has satisfactory bearableness and can be recommended for empiric therapy of combined pathology of urogenital system, caused of protozoyny invasions (different kinds of trichomonas) and microorganisms, associated with bacterial vaginosis, for the women of fertil age and their sexual partners with chronic infections, transmissible mainly sexual a way. This agents have a certain role in development of diseases of the urogenital system. Key words: Trichomonas vaginalis, Trichomonas tenax, Pentatrichomonas hominis, Giardia lamblia, invasion, fertil age.

2020 ◽  
Vol 73 (2) ◽  
pp. 380-383
Author(s):  
Pavlo V. Fedorych ◽  
Gennadiy I. Mavrov ◽  
Tetiana V. Osinska ◽  
Yuliia V. Shcherbakova

The aim was to perform systematic review of genitourinary protozoan invasion and analyze their pathogenicity and the ability to influence the genitourinary infections. Materials and methods: For systematic review of papers the EMBASE and PubMed databases were searched. We also reviewed our own pilot studies using real-time polymerase chain reaction (PCR) to determine Trichomonas tenax, Pentatrichomonas hominis and Giardia lamblia. Conclusions: Trichomonas tenax, Pentatrichomonas hominis, Giardia lamblia can cause genitourinary invasion in addition to Trichomonas vaginalis. Their eradication is obligatory at least for not keeping intact pathogenic microorganisms phagocyted by Trichomonas spp. Defining the protozoan forms is important in preventing of genital infections recurrences and reinfections.


2020 ◽  
Vol 27 ◽  
Author(s):  
Antonio Moreno-Herrera ◽  
Sandra Cortez-Maya ◽  
Virgilio Bocanegra-Garcia ◽  
Bimal Krishna Banik ◽  
Gildardo Rivera

: Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases. Together, they cause more than 500 million infections per year. These protozoa parasites affect both low- and high-income countries and their pharmacological treatment is limited. Therefore, new and more effective drugs in preclinical development could improve overall therapy for parasitic infections even when their mechanisms of action are unknown. In this review, a number of heterocyclic compounds (diamidine, guanidine, quinoline, benzimidazole, thiazole, diazanaphthalene, and their derivatives) reported as antiprotozoal agents are discussed as options for developing new pharmacological treatments for parasitic diseases.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Arlene C. Seña ◽  
Linda A. Goldstein ◽  
Gilbert Ramirez ◽  
Austin Parish ◽  
R. Scott McClelland

1998 ◽  
Vol 95 (12) ◽  
pp. 6860-6865 ◽  
Author(s):  
T. Hashimoto ◽  
L. B. Sanchez ◽  
T. Shirakura ◽  
M. Muller ◽  
M. Hasegawa

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