Low-level laser therapy on the rat’s gastrocnemius morphometry submitted to a rheumatoid arthritis model

Introduction. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disease of unknown origin, mainly affecting synovial joints and related structures, including the adjacent musculature, generating great disability and reduction in quality of life. Aim. This study was designed to investigate the effect of low-level laser therapy (LLLT) on gastrocnemius of Wistar rats subjected to an experimental model of RA. Material and methods. Forty male Wistar rats were used, separated into: acute and chronic, being subdivided into Control Group (CG): without intervention, Lesion Group (LG): submitted to lesion, Laser Control Group (LCG): without lesion and with treatment, and Laser Lesion Group (LLG): submitted to lesion and LLLT. The treatment with LLLT occurred in four points of the right knee, wavelength of 660 nm, energy density of 5 J/cm2, energy per point of 0.003 J. Morphometric analysis was performed using a 40x magnification photomicrograph and analyzed using the Image-Pro-Plus 6.0 program. Results. As result of the acute group there was a difference only for muscle mass, being higher in CG. For the chronic group there was significant difference for cross-sectional area, larger and smaller diameter, again with the control group obtaining higher values than the others, for the number of nuclei LG was lower than CG and LCG, but LLG was not different from any of them. Conclusion. It is concluded that treatment with LLLT was not very effective in reversing the harmful effects of RA on the gastrocnemius muscle.

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Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model

Brazilian Journal Of Pain ◽

10.5935/2595-0118.20200003 ◽

2020 ◽

Vol 3 (1) ◽

Cited By ~ 1

Author(s):

Morgana Neves ◽

Alana Ludemila de Freitas Tavares ◽

Ana Caroline Barbosa Retameiro ◽

Taciane Stein da Silva Leal ◽

Lucinéia de Fátima Chasko Ribeiro ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Laser Therapy ◽

Wistar Rats ◽

Low Level Laser Therapy ◽

Arthritis Model ◽

Low Level ◽

Low Level Laser ◽

Morphological Aspects ◽

Level Laser

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The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

Journal of lasers in medical sciences ◽

10.34172/jlms.2020.34 ◽

2020 ◽

Vol 11 (2) ◽

pp. 204-211 ◽

Cited By ~ 1

Author(s):

Maryam Baghizadeh Fini ◽

Pooya Olyaee ◽

Ahmadreza Homayouni

Keyword(s):

Clinical Trials ◽

Laser Therapy ◽

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Low Level Laser Therapy ◽

Control Group ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Significant Difference

In clinical practice, low-level laser therapy (LLLT) is widely used. The main aim of this review is to assess the effectiveness of LLLT in accelerating tooth movement in human subjects. The PRISMA checklist was utilized as a guideline to carry out this systematic review. The electronic databases were searched from Google Scholar (2014-2018) and PubMed, and comprehensive research on this topic was also manually conducted. Therefore, 77 articles randomized clinical trials (RCTs) or controlled clinical trials (CCTs) were selected. After screening studies, consequently, eleven trials met the inclusion criteria. Eight out of 11 studies showed LLLT has a significant impact on the acceleration of orthodontic tooth movement, and there was no statistically significant difference in the rate of tooth movement between the laser group and the control group in the two remaining studies. Furthermore, five out of 11 articles showed that LLLT has no adverse effects. Although we have some degree of understanding from a cellular point of view to LLLT effects, we still do not know whether these cellular level changes have any effect on the clinical acceleration of orthodontic tooth movement. The results are inconclusive and cannot be generalized to the public community; therefore, well-structured studies are required.

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Physical exercise and low-level laser therapy on the nociception and leukocyte migration of Wistar rats submitted to a model of rheumatoid arthritis

Lasers in Medical Science ◽

10.1007/s10103-019-02905-2 ◽

2019 ◽

Vol 35 (6) ◽

pp. 1277-1287

Author(s):

Morgana Neves ◽

Ana Caroline Barbosa Retameiro ◽

Alana Ludemila de Freitas Tavares ◽

Aline Reginato ◽

Rafael Andrade Menolli ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Physical Exercise ◽

Laser Therapy ◽

Wistar Rats ◽

Leukocyte Migration ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser

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Can Low Level Laser Therapy Benefit Bone Regeneration in Localized Maxillary Cystic Defects? - A Prospective Randomized Control Trial

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2016.140 ◽

2016 ◽

Vol 4 (4) ◽

pp. 720-725 ◽

Cited By ~ 5

Author(s):

Ahmed Abbas Zaky ◽

Hanaa M. Elshenawy ◽

Tarek Abdel Hamed Harhash ◽

Mahmoud Shalash ◽

Noha Ismael Awad

Keyword(s):

Bone Density ◽

Laser Therapy ◽

Predictor Variable ◽

Low Level Laser Therapy ◽

Outcome Variable ◽

Control Group ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Significant Difference

AIM: The aim of the study was to evaluate the effect of Low-Level Laser Therapy (LLLT) on bone formation in cystic defects following cyst enucleation.PATIENTS AND METHODS: The sample was composed of sixteen patients with enucleated maxillary bony cystic lesions. With an age range from 20 - 44 grouped as eight Laser and eight Control patients. Laser group was subjected to low intensity diode laser immediately after surgery and then for three times per week for two weeks using a therapeutic laser irradiation. Group B (control group): patients were not subjected laser therapy.RESULTS: The predictor variable was exposure of bone defect to LLLT or none. The outcome variable was bone density changes measured by digital radiographs at day 1 and days 90 postoperatively. Descriptive and bivariate statistics were computed. There were no statistically significant differences between the 2 groups for the bone density at day 1. There was a statistically significant difference in bone density changes in each group at day 90: Significant at P ≤ 0.05. After adjusting for differences in day 1 for bone density, the estimated mean change in bone density changes at day 90 was significantly larger for Laser compared with control.CONCLUSION: The results of this study suggested that LLLT can enhance bone healing in maxillary cystic defects. This can serve as an adjunct method in preventing possible delayed healing and pathological fractures This also will be helpful for more researchers in early loading in case of dental implants to accelerate osseointegration.

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Assessment of healing of dental implant surgical site following Low-Level Laser Therapy using Bio-Clinical parameters: An Exploratory Study

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-18-00316 ◽

2020 ◽

Author(s):

VARSHA PALLED ◽

DR. JITENDRA RAO ◽

DR. RAGHUWAR DAYAL SINGH ◽

DR. SHUCHI TRIPATHI ◽

DR. KALPANA SINGH ◽

...

Keyword(s):

Laser Therapy ◽

Test Group ◽

Low Level Laser Therapy ◽

Control Group ◽

Clinical Parameters ◽

Implant Stability ◽

Low Level ◽

Implant Stability Quotient ◽

Low Level Laser ◽

Level Laser

The purpose of this study was to evaluate whether Low-Level Laser Therapy (LLLT) improves the healing of the implant surgical site with clinical and biochemical parameters.Thirty patients with an edentulous space spanning a single tooth were selected. The patients were randomly allocated to two groups - the control group and the test group. The test group received laser energy at a power of 2J/cm 2 with a total of 4-6J energy over each implant. Clinical parameters (Implant Stability Quotient, probing index, modified sulcus bleeding index)and osteoprotegerin (OPG) were assessed at baseline and follow-up intervals (2 weeks, 6 weeks, and 3 months).The test group showed significantly higher implant stability quotient compared to thecontrol group at 2 weeks(57.93±3.95 and 35.67±3.08; p<0.01) and 3months(58.86±3.75 and 67.06±3.78; p<0.01). A significant rise in OPG levels of the test group(686.30±125.36pg/ml at baseline and 784.25±108.30pg/ml at 3months;p<0.01) was seen contrary to significant decline in the control group (839.50±249.08pg/ml at baseline,415.30±78.39pg/ml at 3months;p<0.01). Within the limitations of the study, the study suggests that the healing of peri-implant hard and soft tissues may be enhanced with the use of LLLT as an explicit modality during the post-operative period.

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Low-level laser therapy for temporomandibular disorders (tmd) treatment: a systematic review of randomized trials

Journal of Research in Dentistry ◽

10.19177/jrd.v2e52014376-387 ◽

2014 ◽

Vol 2 (5) ◽

pp. 376

Author(s):

Priscila Leite ◽

Nicole Melo ◽

Pâmela Silva ◽

Robinsom Montenegro ◽

Paulo Bonan ◽

...

Keyword(s):

Systematic Review ◽

Temporomandibular Joint ◽

Laser Therapy ◽

Diagnostic Criteria ◽

Temporomandibular Disorders ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Significant Difference

AIM: Conducting a systematic review of randomized clinical trials focusing on the efficacy of LLLT on pain control in patients with TMD, diagnosed by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). MATERIAL AND METHODS: Search was performed at PubMed/MEDLINE database with the terms: (1) “Laser AND temporomandibular disorders”; (2) “Laser AND temporomandibular disorders AND RDC/TMD”; (3) “Low-level laser therapy AND temporomandibular disorders”; (4) “Low-level laser therapy AND temporomandibular disorders AND RDC/TMD”; (5) “Low-level laser therapy AND temporomandibular joint dysfuntion syndrome”; (6) “Low-level laser therapy AND temporomandibular joint dysfuntion syndrome AND RDC/TMD”; (7) “Laser AND temporomandibular joint dysfuntion syndrome” (8) “Laser AND RDC/TMD”; (9) “Low-level laser therapy AND RDC/TMD”. Inclusion criteria: articles need to be randomized clinical trial performed in humans; evaluate the effect of LLLT in the treatment of TMD diagnosed by the use of RDC/TMD; published in English or Portuguese in the last 10 years. Protocol studies and pilot studies were excluded. RESULTS: Ten studies were included. The type of laser used was Gallium Aluminum Arsenide (GaAlAs) diode, with exception of 1 paper, which used super pulsed Gallium Arsenide laser. Eight studies reported decreased in pain levels, in two articles there was no statistically significant difference between test and placebo groups. CONCLUSION: In most studies, LLLT was effective in pain remission, but there is no standardization in parameters like wavelength, output power and frequency. Studies with more complex experimental designs, standardized diagnostic criteria for TMD and defined protocols for the use of LLLT are needed to determine its efficacy in the treatment of TMD.

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