Chronic toxicity of the adamantane-1-ammonium salt of 2-(5-(adamantane-1-yl)-4-phenyl-1,2,4-triazole-3-thio)acetic acid substance

Heating the ammonium salt of (4-carboxy-1-methyl-4-piperidinyl)acetic acid (XII) gave 8-methyl-2,8-diazaspiro[4,5]decane-1,3-dione (II) which was N-alkylated with 2-bromoethanol and 4-bromobutanol to give the alcohols III and V. Compound III was transformed to the chloro compound VI which was reacted with the sodium salt of hexahydrobenzilic acid to give the ester VII. Compound V was transformed to the 4-toluenesulfonic ester VIII which reacted with 1-(2-pyrimidinyl)piperazine and gave IX. 2-(2-Propyl)-2,8-diazaspiro[4,5]decane-1,3-dione (XVIII) was similarly transformed via XIX to XX which reacted with the sodium salts of diphenylacetic, benzilic, hexahydrobenzilic, and (2-oxo-1-pyrrolidinyl)acetic acid to give the esters XXI-XXIV. The esters VII and XXI-XXIV were transformed to the methiodides. The compounds prepared were tested in the lines of activity of the analogous "RS-86" (I) but proved inactive.

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Scientific Opinion on the safety assessment of the substance, Perfluoro{acetic acid, 2-[(5-methoxy-1, 3-dioxolan-4-yl)oxy]}, ammonium salt, CAS No 1190931-27-1, for use in food contact materials

EFSA Journal ◽

10.2903/j.efsa.2014.3718 ◽

2014 ◽

Vol 12 (6) ◽

pp. 3718 ◽

Cited By ~ 1

Author(s):

Keyword(s):

Acetic Acid ◽

Ammonium Salt ◽

Safety Assessment ◽

Contact Materials ◽

Food Contact Materials ◽

Food Contact ◽

Scientific Opinion

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Molar volumes of aqueous acetic acid-ammonium salt solutions

Electrochimica Acta ◽

10.1016/0013-4686(77)80043-1 ◽

1977 ◽

Vol 22 (10) ◽

pp. 1083-1085 ◽

Cited By ~ 2

Author(s):

R.L. Blokhra ◽

S.K. Agarwal ◽

Neerja Sakhuja

Keyword(s):

Acetic Acid ◽

Ammonium Salt ◽

Aqueous Acetic Acid ◽

Salt Solutions ◽

Molar Volumes

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Ectodesmata as Revealed By Freeze-Etch Preparations of Plant Epidermal Cell Walls

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072782 ◽

1973 ◽

Vol 31 ◽

pp. 468-469

Author(s):

N.C. Lyon ◽

W. C. Mueller

Keyword(s):

Electron Microscopy ◽

Acetic Acid ◽

Nitric Acid ◽

Oxalic Acid ◽

Light Microscopy ◽

Epidermal Cell ◽

Cell Walls ◽

Plant Viruses ◽

Plant Leaves ◽

Thin Sections

Schumacher and Halbsguth first demonstrated ectodesmata as pores or channels in the epidermal cell walls in haustoria of Cuscuta odorata L. by light microscopy in tissues fixed in a sublimate fixative (30% ethyl alcohol, 30 ml:glacial acetic acid, 10 ml: 65% nitric acid, 1 ml: 40% formaldehyde, 5 ml: oxalic acid, 2 g: mecuric chloride to saturation 2-3 g). Other workers have published electron micrographs of structures transversing the outer epidermal cell in thin sections of plant leaves that have been interpreted as ectodesmata. Such structures are evident following treatment with Hg++ or Ag+ salts and are only rarely observed by electron microscopy. If ectodesmata exist without such treatment, and are not artefacts, they would afford natural pathways of entry for applied foliar solutions and plant viruses.

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Catalyst- and oxidant-free electrochemical para-selective hydroxylation of N-arylamides in batch and continuous-flow

Green Chemistry ◽

10.1039/d0gc02294b ◽

2020 ◽

Vol 22 (19) ◽

pp. 6437-6443

Author(s):

Cheng-Kou Liu ◽

Meng-Yi Chen ◽

Xin-Xin Lin ◽

Zheng Fang ◽

Kai Guo

Keyword(s):

Ammonium Salt ◽

Quaternary Ammonium ◽

Continuous Flow ◽

Quaternary Ammonium Salt ◽

Selective Hydroxylation

A catalyst-, oxidant-, acidic solvent- and quaternary ammonium salt-free electrochemical para-selective hydroxylation of N-arylamides at rt in batch and continuous-flow was developed.

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