Abstract
ObjectivesSome studies have reported that visceral fat volume measured by computed tomography (CT) was a risk factor for colorectal adenoma (CRA). However, CT is not a good method for risk stratification in clinical use for its radiation. Bioelectrical impedance analysis (BIA) is a non-invasive method for assessment of body composition. The aim of current study was to evaluate the association of body fat measured by BIA with occurrence of CRA.Patients and methods:A total of 410 participants who had underwent screening colonoscopy from Jul 2017 to Dec 2019 in our center were recruited, including 230 with adenoma and 180 without adenoma detected. Body fat of participants were measured by BIA, including body fat mass (BFM), body fat percent (BFP), and waist-to-hip fat ratio. Parameters of metabolic syndrome (MetS) were also measured, including waist circumference, blood pressure, fasting blood glucose, blood level of triglyceride, cholesterol and high-density lipoprotein.ResultsAccording to univariate analysis, age, male proportion, BMI, waist circumference, body fat mass, waist-to-hip fat ratio, blood pressure, and FBG were higher in adenoma group than adenoma-free group, p < 0.05. On multivariate analysis (adjusted for age, sex, smoking, drinking, family history of CRC, etc.), High waist-to-hip fat ratio measured by BIA was associated with occurrence of CRA (compared with normal waist-to-hip fat ratio, OR 1.84; 95% CI, 1.09–3.09; p = 0.02). High waist circumference, as a component of MetS, was also independently associated with CRA (OR 1.90; 95% CI 1.17–3.08, p = 0.01).ConclusionBody fat distribution measured by BIA is associated with occurrence of CRA. Central obesity is a risk factor for CRA.Trial registration: This study was prospectively registered in Chinese Clinical Trials Registry (www.chictr.org.cn; registry number: ChiCTR-RRC-17010862).