Biomarkers of inflammation, parameters characterizing obesity and cardiac remodeling in patients with atrial fibrillation and metabolic syndrome

Aim. To determine the blood level of inflammatory markers, parameters characterizing obesity and cardiac remodeling in patients with atrial fibrillation (AF) in combination with metabolic syndrome (MS).Material and methods. This single-stage case-control study included 677 subjects aged 35 to 65 years: patients with MS (n=407), of which 128 patients with AF; comparison group — patients with AF without MS (n=75); control group — practically healthy subjects without cardiovascular diseases and metabolic disorders (n=195).Results. It was found that the blood concentration of circulating pro-inflammatory biomarkers in patients with AF and MS is higher than in patients with AF without MS: C-reactive protein (CRP) (4,43 (2,68-4,98) and 2,33 (1,08-4,7) mg/L, p<0,0001), interleukin-6 (IL-6) (2,5 (1,28-5,13) and 1,27 (0,68-2,7) pg/ml, p<0,0001) and tumor necrosis factor-α (TNF-α) (5,18 (2,63-7,32) and 3,42 (2,115,48) pg/ml, p<0,0001). The serum CRP concentration positively correlates with left (ρ=0,451, p<0,0001) and right atrial (ρ=0,412, p<0,000) volumes, as well as with the waist circumference (ρ=0,503, p<0,001) and epicardial fat thickness (ρ=0,550, p<0,001). Plasma IL-6 and serum TNF-α levels correlated to a lesser extent with parameters characterizing atrial remodeling, but had a strong positive relationship with epicardial fat thickness. According to multivariate analysis, it was found that an increase in the epicardial fat thickness had a greater effect on an increase in blood concentration of CRP, IL-6 and TNF-α, in contrast to other parameters characterizing obesity, such as body mass index and waist circumference.Conclusion. An increase in the blood concentration of proinflammatory biomarkers CRP, IL-6, and TNF-α is associated with cardiac remodeling and epicardial fat thickness in patients with MS and probably has a pathogenetic role in increasing the AF risk in this cohort of patients.

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Role of galectin 3 and epicardial fat thickness in the development of atrial fibrillation in patients with metabolic syndrome

The Scientific Notes of the I P Pavlov St Petersburg State Medical University ◽

10.24884/1607-4181-2015-22-1-43-46 ◽

2015 ◽

Vol 22 (1) ◽

pp. 43-46 ◽

Cited By ~ 1

Author(s):

V. A. Ionin ◽

O. V. Listopad ◽

S. E. Nifontov ◽

E. I. Baranova ◽

A. V. Soboleva ◽

...

Keyword(s):

Atrial Fibrillation ◽

Metabolic Syndrome ◽

Persistent Atrial Fibrillation ◽

Epicardial Fat ◽

Control Group ◽

Epicardial Fat Thickness ◽

Galectin 3 ◽

Fat Thickness ◽

Definition Of ◽

Healthy Persons

Objective. To evaluate the epicardial fat thickness (EFT) in patients with metabolic syndrome (MS), including paroxysmal and persistent atrial fibrillation (AF). To relate EFT to the fibroid heart marker, i.e. galectin 3. Materials and methods. We examined 100 patients with MS (50 with AF), and 50 healthy persons made the control group. Serum galectin 3 was measured by ELISA method. The EFT was measured with echocardiography. Results. EFT in patients with MS was twofold higher than in healthy persons. EFT in patients with MS and AF didn't differ significantly from that in patients with MS without AF. Positive correlation between the levels of EFT and galectin 3 in serum was revealed. Serum galectin 3 and EFT were associated with atrial fibrillation in patients with MS (OR:1,27, 95% CI 1,02-1,58 and OR:1,73, 95% CI 1,37-2,19, correspondingly).Conclusion. Definition of EFT at echocardiography can be used in the assessment of risk AF in patients with MS.

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OP-117 Increased Epicardial Fat Thickness is Associated with High Mean Platelet Volume in Metabolic Syndrome

The American Journal of Cardiology ◽

10.1016/j.amjcard.2014.01.094 ◽

2014 ◽

Vol 113 (7) ◽

pp. S34

Author(s):

D. Tok ◽

K. Çağlı ◽

N. Başar ◽

İ. Kadife ◽

O. Turak ◽

...

Keyword(s):

Metabolic Syndrome ◽

Mean Platelet Volume ◽

Epicardial Fat ◽

Platelet Volume ◽

Epicardial Fat Thickness ◽

Fat Thickness

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Relationship between the epicardial fat thickness and total atrial conduction time in patients with lone paroxysmal atrial fibrillation

International Journal of Cardiology ◽

10.1016/j.ijcard.2015.03.091 ◽

2015 ◽

Vol 185 ◽

pp. 106-108 ◽

Cited By ~ 2

Author(s):

Uğur Canpolat ◽

Kudret Aytemir ◽

Necla Özer ◽

Ali Oto

Keyword(s):

Atrial Fibrillation ◽

Paroxysmal Atrial Fibrillation ◽

Epicardial Fat ◽

Conduction Time ◽

Epicardial Fat Thickness ◽

Atrial Conduction Time ◽

Fat Thickness

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Epicardial fat thickness: A new predictor of successful electrical cardioversion and atrial fibrillation recurrence

Echocardiography ◽

10.1111/echo.14178 ◽

2018 ◽

Vol 35 (12) ◽

pp. 1926-1931 ◽

Cited By ~ 8

Author(s):

Seçkin Dereli ◽

Adil Bayramoğlu ◽

Osman Can Yontar ◽

Sinan Cerşit ◽

Mustafa Ozan Gürsoy

Keyword(s):

Atrial Fibrillation ◽

Electrical Cardioversion ◽

Epicardial Fat ◽

Atrial Fibrillation Recurrence ◽

Epicardial Fat Thickness ◽

Fat Thickness

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Abstract WP233: Epicardial Fat Thickness, Free Fatty Acid and Pro-BNP Predict Atrial Fibrillation in Acute Ischemic Stroke

Stroke ◽

10.1161/str.48.suppl_1.wp233 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Jin-Hyung Lee ◽

Meyung-Kug Kim ◽

Bong-Goo Yoo

Keyword(s):

Atrial Fibrillation ◽

Ischemic Stroke ◽

Fatty Acid ◽

Free Fatty Acid ◽

Acute Ischemic Stroke ◽

Epicardial Fat ◽

Epicardial Fat Thickness ◽

Fat Thickness ◽

Hs Crp ◽

D Dimer

Background/Objectives: Detection of atrial fibrillation (AF) is important for diagnosis of cardioembolic stroke. Few studies that cardioembolic stroke relate to some biomarkers such as high sensitive C-reactive protein (hs-CRP), free fatty acid (FFA), pro-brain natriuretic peptide (pro-BNP) and D-dimer have been reported. FFAs are major components of epicardial fat. Increased epicardial fat thickness (EFT) is known to be associated with the presence of AF. The object of this study is to find the useful markers to distinguish stroke with AF in acute ischemic stroke. Design/Method: Total 214 consecutive patients (mean age, 66.8±12.3 years; 39.7% women; 16.4% AF group) with acute ischemic stroke within 72 hours of onset were retrospectively enrolled. We analyzed the EFT and the several biomarkers between stroke with and without AF. Results: Age, heart rate, FFA, pro-BNP, hs-CRP, HDL and the frequency of woman were significantly higher in AF group (p <0.05). Estimated glomerular filtration rate (eGFR) was significantly lower in AF group (p<0.05). D-dimer and myoglobin were no significant difference. EFT (6.45±1.18 vs 5.30±1.23 mm, p<0.001), Left atrium (LA) diameter and LA volume were significantly higher in AF group. The respective cut-off value of EFT, FFA and pro-BNP for prediction of the AF were 5.58mm, 1226.5 μEq/ml and 295.0 pg/ml (sensitivity 85%, specificity 61%, AUC 0.76 for EFT; 67%, 93%, 0.79 for FFA; 82%, 84%, 0.88 for pro-BNP). Multivariate logistic regression analysis demonstrated that age, FFA and EFT were independently associated with the presence of AF (p<0.05). Conclusions: The combination of EFT, FFA and pro-BNP can be a useful marker for the prediction of the AF in acute ischemic stroke.

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