scholarly journals Strength and Balance Training for Preventing Falls in Prostate Cancer Patients Receiving Androgen Deprivation Therapy: Case Report

2020 ◽  
Vol 29 (4) ◽  
pp. 402-408
Author(s):  
Parivash Jamrasi ◽  
Kyunghee Lee ◽  
Kyoungmin Noh ◽  
Juhyun Park ◽  
Hyeon Jeong ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Risk Factors ◽  
Androgen Deprivation Therapy ◽  
Functional Assessment ◽  
Physical Functioning ◽  
Bone Health ◽  
Balance Training ◽  
Balance Confidence

PURPOSE: Prostate cancer (PCa) survivors are at risk of falls due to the accelerated physiological changes following receiving androgen deprivation therapy (ADT). Thus, follow-up care of PCa survivors after treatment is vital to prevent high healthcare costs of fall-induced injuries and maintain their quality of life (QOL). Yet, we do not know what type of exercise can be beneficial to decrease falls risk factors in PCa patients. Here we report for the first time the possible advantage of strength and balance training (SBT) program on key components of falls predictors such as balance confidence, physical functioning performance and musculoskeletal health that might lead the next researcher to test this hypothesis on larger group of subjects.METHODS: For this purpose, center-based SBT exercise with resistance band conducted twice a week for 8 weeks and we compared outcomes of bone health, physical functioning performance, balance confidence, fatigue and quality of life of two cases with PCa with one control subject at the baseline and after intervention period.RESULTS: Following the exercise intervention, improvements were observed in bone mineral density (BMD), functional movement screen (FMS), backward walk and timed up and go (TUG) tests as well as outcomes of self-reported functional assessment of chronic illness therapy–fatigue (FACT-F) and functional assessment of cancer therapy-prostate (FACT-P); however, we could not declare the effects of SBT on lower body strength and power.CONCLUSIONS:The 8-weeks intervention had positive impact on some falls risk factors (i.e., bone health, functional and balance performance) as well as QOL for participants of SBT program. However due to small number of participants we could not apply further quantitative analysis methods to make any conclusion on the efficacy of the intervention.

Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review

2014 ◽  
Vol 32 (4) ◽  
pp. 335-346 ◽  
Author(s):  
Jason R. Gardner ◽  
Patricia M. Livingston ◽  
Steve F. Fraser
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Systematic Review ◽  
Adverse Effects ◽  
Androgen Deprivation Therapy ◽  
Bone Health ◽  
Cardiometabolic Risk ◽  
Androgen Deprivation ◽  
Cochrane Library

Purpose Androgen-deprivation therapy is a commonly used treatment for men with prostate cancer; however, the adverse effects can be detrimental to patient health and quality of life. Exercise has been proposed as a strategy for ameliorating a range of these treatment-related adverse effects. We conducted a systematic review of the literature regarding the effects of exercise on treatment-related adverse effects in men receiving androgen-deprivation therapy for prostate cancer. Methods An online electronic search of the Cochrane Library, EMBASE, MEDLINE, CINAHL, SPORTDiscus, and Health Source databases was performed to identify relevant peer-reviewed articles published between January 1980 and June 2013. Eligible study designs included randomized controlled trials as well as uncontrolled trials with pre- and postintervention data. Information was extracted regarding participant and exercise intervention characteristics as well as the effects of exercise on bone health, body composition, physical performance, cardiometabolic risk, fatigue, and quality of life. Results Ten studies were included, with exercise interventions involving aerobic and/or resistance training. Exercise training demonstrated benefits in muscular strength, cardiorespiratory fitness, functional task performance, lean body mass, and fatigue, with inconsistent effects observed for adiposity. The impact of exercise on bone health, cardiometabolic risk markers, and quality of life are currently unclear. Conclusion Among patients with prostate cancer treated with androgen-deprivation therapy, appropriately prescribed exercise is safe and may ameliorate a range of treatment-induced adverse effects. Ongoing research of high methodologic quality is required to consolidate and expand on current knowledge and to allow the development of specific evidence-based exercise prescription recommendations.

scholarly journals Pathophysiology of Bone Loss in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy and Lifestyle Modifications for the Management of Bone Health: A Comprehensive Review

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1529
Author(s):  
Tae Jin Kim ◽  
Kyo Chul Koo
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Bone Health ◽  
Androgen Deprivation ◽  
Current Evidence ◽  
Lifestyle Modifications ◽  
Comprehensive Review

Androgen-deprivation therapy (ADT) is a systemic therapy administered for the management of advanced prostate cancer (PCa). Although ADT may improve survival, long-term use reduces bone mass density (BMD), posing an increased risk of fracture. Considering the long natural history of PCa, it is essential to preserve bone health and quality-of-life in patients on long-term ADT. As an alternative to pharmacological interventions targeted at preserving BMD, current evidence recommends lifestyle modifications, including individualized exercise and nutritional interventions. Exercise interventions include resistance training, aerobic exercise, and weight-bearing impact exercise, and have shown efficacy in preserving BMD. At the same time, it is important to take into account that PCa is a progressive and debilitating disease in which a substantial proportion of patients on long-term ADT are older individuals who harbor axial bone metastases. Smoking cessation and limited alcohol consumption are commonly recommended lifestyle measures in patients receiving ADT. Contemporary guidelines regarding lifestyle modifications vary by country, organization, and expert opinion. This comprehensive review will provide an evidence-based, updated summary of lifestyle interventions that could be implemented to preserve bone health and maintain quality-of-life throughout the disease course of PCa.

scholarly journals Impact of Radiotherapy When Added to Androgen-Deprivation Therapy for Locally Advanced Prostate Cancer: Long-Term Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial

2015 ◽  
Vol 33 (19) ◽  
pp. 2151-2157 ◽  
Author(s):  
Michael Brundage ◽  
Matthew R. Sydes ◽  
Wendy R. Parulekar ◽  
Padraig Warde ◽  
Richard Cowan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Cancer Therapy ◽  
Androgen Deprivation Therapy ◽  
Functional Assessment ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Androgen Deprivation ◽  
Locally Advanced Prostate Cancer

Purpose The NCIC CTG PR3/MRC PR07 randomized phase III trial compared androgen-deprivation therapy (ADT) alone versus ADT with radiotherapy (RT) for patients with locally advanced prostate cancer. This article reports the health-related quality-of-life (HRQOL) outcomes of this trial. Patients and Methods A total of 1,205 patients were randomly allocated to either ADT alone or ADT with RT. HRQOL was assessed at baseline and every 6 months thereafter using the European Organisation for Research and Treatment of Cancer Core Questionnaire and a prostate cancer–specific checklist or the Functional Assessment of Cancer Therapy–Prostate questionnaire. Mean changes from baseline scores for five function domains and nine symptom domains were analyzed as those most relevant to ADT and RT. The proportions of patients with improved, stable, or worsened HRQOL scores according to instrument-specific minimal important differences were calculated. Results Baseline questionnaires were completed by 1,028 patients (88%). At 6 months, RT had a statistically significant impact on mean score for bowel symptoms (P = .02), diarrhea (P < .001), urinary function (P = .003), and erectile dysfunction (P = .008); by 3 years, however, there were no significant between-group differences in any domain. Generalized linear mixed modeling revealed no significant between-arm differences in any of the function scales but showed significant deterioration in both arms over time for Functional Assessment of Cancer Therapy–Prostate total score, treatment outcome index, and physical and functional well-being. Conclusion The addition of RT to ADT for patients with locally advanced prostate cancer significantly improved overall survival and had only modest and transient negative impact on relevant domains of HRQOL.

Predictors of depression, anxiety and quality of life in patients with prostate cancer receiving androgen deprivation therapy

2013 ◽  
Vol 22 (10) ◽  
pp. 2169-2176 ◽  
Author(s):  
Kelly Chipperfield ◽  
Jane Fletcher ◽  
Jeremy Millar ◽  
Joanne Brooker ◽  
Robin Smith ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Predictors Of Depression

Measuring quality of life in men with prostate cancer using the Functional Assessment of Cancer Therapy-prostate instrument

Urology ◽  
1997 ◽  
Vol 50 (6) ◽  
pp. 920-928 ◽  
Author(s):  
Peg Esper ◽  
Fei Mo ◽  
Gerald Chodak ◽  
Michael Sinner ◽  
David Cella ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Cancer Therapy ◽  
Functional Assessment

Role Wii Fit exer-games in improving balance confidence and quality of life in elderly population

2021 ◽  
Vol 71 (9) ◽  
pp. 1-10
Author(s):  
Kiran Khushnood ◽  
Shafaq Altaf ◽  
Nasir Sultan ◽  
Malik Muhammad Ali Awan ◽  
Riafat Mehmood ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Fall Risk ◽  
Elderly Population ◽  
Balance Training ◽  
Control Group ◽  
Balance Confidence ◽  
Wii Fit ◽  
And Control ◽  
Experimental Group

Objective: To determine the effects of Wii Fit exer-gaming on balance confidence, quality of life and fall risk in elderly population Methods: A double blinded randomized control was conducted at Kulsum International Hospital, Islamabad from July 31st to October 30th, 2018. Following screening, 90 subjects fulfilled inclusion criteria and gave consent to be part of trial. Subjects were randomly allocated into experimental and control group by concealed envelope method. After baseline assessment, experimental group received Wii fit gaming while controls received balance training for 30 minutes twice a week for 8 weeks. Activities balance confidence (ABC), Euro 5Q5L, timed up and go (TUG) and Fukuda were used as outcome measures. Data was analysed by SPSS 21. Results: ABC improved in experimental group from 76.47±3.69 to 86.53±3.99, and in control group from 77.51±3.01 to 82.70±2.78 with significance < 0.001. The components of Euro 5Q5L; mobility, self-care, usual activities, pain/discomfort, anxiety/depression have changed with intergroup significance of 0.05, 0.006, 0.595, <0.001, 0.001 respectively. TUG and Fukuda improved in experimental and control group as 15.73±2.30 to 12.02±1.40 and 16.24±1.75 to 13.68±1.58 with significance <0.001, and from 41.78±6.to 71 to 30.09±8.05 and 43.36±5.59 to 38.68±5.75 with significance <0.001 respectively. Conclusion: Wii fit improves balance confidence and quality of life reducing fall risk in elderly. Clinical Trial Number: IRCT20180417039344N1 Keywords: Balance training, Elderly, Exer-gaming, Quality of life, Wii fit Continuous...

Androgen Deprivation Therapy for Prostate Cancer: Recommendations to Improve Patient and Partner Quality of Life

2010 ◽  
Vol 7 (9) ◽  
pp. 2996-3010 ◽  
Author(s):  
Stacy Elliott ◽  
David M. Latini ◽  
Lauren M. Walker ◽  
Richard Wassersug ◽  
John W. Robinson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Improve Patient
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