Novel therapeutic strategies using nanodrug delivery, stem cells and combination therapy for CNS trauma and neurodegenerative disorders

2013 ◽  
Vol 13 (10) ◽  
pp. 1085-1088 ◽  
Author(s):  
Hari S Sharma ◽  
Dafin F Muresanu ◽  
Aruna Sharma
Keyword(s):  
Stem Cells ◽  
Combination Therapy ◽  
Neurodegenerative Disorders ◽  
Therapeutic Strategies ◽  
Nanodrug Delivery ◽  
Cns Trauma ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Novel Therapeutic Strategies for Ovarian Cancer Stem Cells

2020 ◽  
Vol 10 ◽  
Author(s):  
Nastassja Terraneo ◽  
Francis Jacob ◽  
Anna Dubrovska ◽  
Jürgen Grünberg
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Strategies ◽  
Ovarian Cancer Stem Cells ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Neuroprotective Potential of GDF11: Myth or Reality?

2019 ◽  
Vol 20 (14) ◽  
pp. 3563 ◽  
Author(s):  
Luc Rochette ◽  
Gabriel Malka
Keyword(s):  
Neurodegenerative Diseases ◽  
Blood Plasma ◽  
Neurodegenerative Disorders ◽  
Brain Aging ◽  
Therapeutic Strategies ◽  
Blood Concentrations ◽  
Age Related ◽  
Novel Therapeutic Strategies ◽  
The Brain ◽  
Novel Therapeutic

In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a “rejuvenating factor” opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.

scholarly journals Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management

2005 ◽  
Vol 18 (3) ◽  
pp. 556-569 ◽  
Author(s):  
Brad Spellberg ◽  
John Edwards ◽  
Ashraf Ibrahim
Keyword(s):  
Combination Therapy ◽  
Liposomal Amphotericin ◽  
Iron Chelator ◽  
Therapeutic Strategies ◽  
Rapid Diagnosis ◽  
High Dose ◽  
Immunocompromised Patients ◽  
Life Threatening ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

SUMMARY Mucormycosis is a life-threatening fungal infection that occurs in immunocompromised patients. These infections are becoming increasingly common, yet survival remains very poor. A greater understanding of the pathogenesis of the disease may lead to future therapies. For example, it is now clear that iron metabolism plays a central role in regulating mucormycosis infections and that deferoxamine predisposes patients to mucormycosis by inappropriately supplying the fungus with iron. These findings raise the possibility that iron chelator therapy may be useful to treat the infection as long as the chelator does not inappropriately supply the fungus with iron. Recent data support the concept that high-dose liposomal amphotericin is the preferred monotherapy for mucormycosis. However, several novel therapeutic strategies are available. These options include combination therapy using lipid-based amphotericin with an echinocandin or with an azole (largely itraconazole or posaconazole) or with all three. The underlying principles of therapy for this disease remain rapid diagnosis, reversal of underlying predisposition, and urgent surgical debridement.

scholarly journals The role of adipose stem cells in inflammatory bowel disease: From biology to novel therapeutic strategies

2016 ◽  
Vol 17 (9) ◽  
pp. 889-898 ◽  
Author(s):  
Francesco De Francesco ◽  
Maurizio Romano ◽  
Laura Zarantonello ◽  
Cesare Ruffolo ◽  
Daniele Neri ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Bowel Disease ◽  
Therapeutic Strategies ◽  
Adipose Stem Cells ◽  
Inflammatory Bowel ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Cancer Stem Cells in Multiple Myeloma and the Development of Novel Therapeutic Strategies

Oncogenomics ◽  
2019 ◽  
pp. 121-137 ◽  
Author(s):  
Franco Dammacco ◽  
Patrizia Leone ◽  
Franco Silvestris ◽  
Vito Racanelli ◽  
Angelo Vacca
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Cancer Stem Cells ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic
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