Neuropsychiatry as a medical specialty is significantly underrepresented in India, with neurology and psychiatry giving each other a wide berth in many of the country’s regions. This chapter reviews the state of neuropsychiatric services in India and South Asia, before moving on to explore what constitutes a Comprehensive Neuropsychiatry Programme (CNP). This encompasses education and research into neuropsychiatric outcomes, advocacy at a governmental level, and community-engendered activities, all with a view to attaining optimal levels of participation in activities of daily living (ADLs), health-related quality of life (HRQoL), and various social and educational milestones. The model employed by a multidisciplinary team for use in developing nations is then described, along with a case study to demonstrate best practice.