scholarly journals Low dose systemic or intralesional meglumine antimoniate treatment for American tegumentary leishmaniasis results in low lethality, low incidence of relapse, and low late mucosal involvement in a referral centre in Rio de Janeiro, Brazil (2001-2013)

2017 ◽  
Vol 112 (12) ◽  
pp. 838-843 ◽  
Author(s):  
Lucia Regina Brahim ◽  
Cláudia Maria Valete-Rosalino ◽  
Liliane de Fátima Antônio ◽  
Maria Inês Fernandes Pimentel ◽  
Marcelo Rosandiski Lyra ◽  
...  
Keyword(s):  
Rio De Janeiro ◽  
Low Dose ◽  
Referral Centre ◽  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
Mucosal Involvement ◽  
American Tegumentary Leishmaniasis ◽  
Low Incidence

Comparison of the sensitivity of imprint and scraping techniques in the diagnosis of American tegumentary leishmaniasis in a referral centre in Rio de Janeiro, Brazil

2011 ◽  
Vol 109 (3) ◽  
pp. 927-933 ◽  
Author(s):  
Cintia Xavier de Mello ◽  
Armando de Oliveira Schubach ◽  
Raquel Vasconcellos Carvalho de Oliveira ◽  
Fátima Conceição-Silva ◽  
Maria Inês Fernandes Pimentel ◽  
...  
Keyword(s):  
Rio De Janeiro ◽  
Referral Centre ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

American Tegumentary Leishmaniasis in Older Adults: 44 Cases Treated with an Intermittent Low-Dose Antimonial Schedule in Rio de Janeiro, Brazil

2010 ◽  
Vol 58 (3) ◽  
pp. 614-616 ◽  
Author(s):  
Érica de Camargo Ferreira e Vasconcellos ◽  
Armando de Oliveira Schubach ◽  
Cláudia Maria Valete-Rosalino ◽  
Renata de Souza Coutinho ◽  
Fátima Conceição-Silva ◽  
...  
Keyword(s):  
Older Adults ◽  
Rio De Janeiro ◽  
Low Dose ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Clinical features and therapeutic response in adult and pediatric patients with American tegumentary leishmaniasis in Rio de Janeiro

2019 ◽  
Author(s):  
Tatiana C R Senna ◽  
Maria Inês F Pimentel ◽  
Liliane F A Oliveira ◽  
Marcelo R Lyra ◽  
Mauricio N Saheki ◽  
...  
Keyword(s):  
Clinical Features ◽  
Rio De Janeiro ◽  
Pediatric Patients ◽  
Therapeutic Response ◽  
Age Groups ◽  
Healing Time ◽  
The Body ◽  
Reference Centre ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Abstract Background American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis. Methods A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients. Results The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023). Conclusions This study adds to the body of knowledge on differences that exist between different age groups in ATL.

scholarly journals American tegumentary leishmaniasis: an uncommon clinical and histopathological presentation

2013 ◽  
Vol 88 (2) ◽  
pp. 260-262 ◽  
Author(s):  
Adrilena Lopes Adriano ◽  
Paula Azevedo Borges Leal ◽  
Marcelle Parente Breckenfeld ◽  
Igor dos Santos Costa ◽  
Clarisse Almeida ◽  
...  
Keyword(s):  
Male Patient ◽  
Clinical Manifestation ◽  
Unusual Presentation ◽  
Solitary Lesion ◽  
Meglumine Antimoniate ◽  
Histopathological Findings ◽  
Histological Sections ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis ◽  
Extended Duration

We report a case of an unusual presentation of American Tegumentary Leishmaniasis involving a male patient with a solitary lesion on the ear lobe, persisting with minimal increase for at least six months without ulceration or related symptoms. The histological sections showed epithelial atrophy and a large number of structures consistent with Leishmania sp. amastigotes within macrophages. Treatment commenced with meglumine antimoniate resulting in regression of the condition. This report is of importance given the unusual clinical manifestation and histopathological findings in this case and the fact that there was low correlation with the extended duration of the disease.

scholarly journals STATUS OF THE AMERICAN TEGUMENTARY LEISHMANIASIS IN THE STATE OF RIO DE JANEIRO , BRAZIL, FROM 2004 TO 2013

2016 ◽  
Vol 58 (0) ◽  
Author(s):  
Gilmar Ferreira VITA ◽  
Maria Angélica Vieira DA COSTA PEREIRA ◽  
Ildemar FERREIRA ◽  
Argemiro SANAVRIA ◽  
Celso Guimarães BARBOSA ◽  
...  
Keyword(s):  
Rio De Janeiro ◽  
The State ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

scholarly journals Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions

2018 ◽  
Vol 51 (6) ◽  
pp. 769-780 ◽  
Author(s):  
Jamyra Iglesias Cataldo ◽  
Fátima Conceição-Silva ◽  
Liliane de Fátima Antônio ◽  
Armando de Oliveira Schubach ◽  
Mauro Célio de Almeida Marzochi ◽  
...  
Keyword(s):  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

scholarly journals Ecological aspects of sandfly fauna (Diptera: Psychodidae, Phlebotominae) of Sumidouro District, State of Rio de Janeiro, Brazil

2020 ◽  
Author(s):  
João Ricardo Carreira Alves ◽  
Cleber Nascimento do Carmo ◽  
Rodrigo Caldas Menezes ◽  
Mauricio Luís Vilela ◽  
Jacenir Reis dos Santos-Mallet
Keyword(s):  
Poisson Regression ◽  
Rio De Janeiro ◽  
Environmental Changes ◽  
Sand Fly ◽  
Tegumentary Leishmaniasis ◽  
Ecological Aspects ◽  
American Tegumentary Leishmaniasis ◽  
Complementary Study ◽  
Janeiro State ◽  
Made In

AbstractAiming to compare and update the sand fly fauna of Portão de Pedra site, Sumidouro District, Rio de Janeiro State, Brazil, and considering the environmental changes occurred, the biology and ecology of the local sandfly species were examined five years later as a complementary study carried. Captures were made in the cave, surroundings of cave and forest of the region, from 6 p.m. to 6 a.m. 2 3 2 3 sandflies of eigth species of the Lutzomyia were captured: L. gasparviannai, L. edwardsi, L. tupynambai, L. hirsuta, L. whitmani, L. migonei, L. intermedia, Lutzomyia. sp and one species of the Brumptomyia Kind: B. brumpti. In 2009 and 2010 were collected 1756 samples from ten species of the former genus and two of the second. L. gasparviannai was predominant, in the three collection sites, in both periods. Five species implicated as vector of Leishmania: L. intermedia, L. whitmani, L. migonei, L. hirsuta and L. davisi have been collected in the area. Poisson regression and ANOVA were used to perform statistical analysis of species most relevant. The record of L. intermedia and a case of American tegumentary leishmaniasis are relevant to public health of municipality and of state of Rio de Janeiro.

scholarly journals RESOLUTION OF CUTANEOUS LEISHMANIASIS AFTER ACUTE ECZEMA DUE TO INTRALESIONAL MEGLUMINE ANTIMONIATE

2014 ◽  
Vol 56 (4) ◽  
pp. 361-362 ◽  
Author(s):  
Erica de Camargo Ferreira e Vasconcellos ◽  
Maria Inês Fernandes Pimentel ◽  
Cláudia Maria Valete-Rosalino ◽  
Maria de Fátima Madeira ◽  
Armando de Oliveira Schubach
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Amphotericin B ◽  
Rio De Janeiro ◽  
Low Dose ◽  
Reference Center ◽  
Meglumine Antimoniate ◽  
Cutaneous Hypersensitivity ◽  
Intralesional Administration ◽  
The Right

We report a case of a 42 year-old female, who came to a leishmaniasis reference center in Rio de Janeiro, Brazil, presenting a cutaneous leishmaniasis lesion in the right forearm. Treatment with low-dose intramuscular meglumine antimoniate (MA) (5 mg Sb5+/kg/day) was initiated, with improvement after 28 days, although with the development of generalized eczema. After 87 days, the lesion worsened. Patient refused treatment with amphotericin B. MA was then infiltrated in the lesion, in two sessions, resulting in local eczema, with bullae formation; however, twenty days after, both the ulcer and eczema receded. Intralesional administration of MA should be used carefully when previous cutaneous hypersensitivity is detected.

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