scholarly journals Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions

2018 ◽  
Vol 51 (6) ◽  
pp. 769-780 ◽  
Author(s):  
Jamyra Iglesias Cataldo ◽  
Fátima Conceição-Silva ◽  
Liliane de Fátima Antônio ◽  
Armando de Oliveira Schubach ◽  
Mauro Célio de Almeida Marzochi ◽  
...  
Keyword(s):  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

scholarly journals American tegumentary leishmaniasis: an uncommon clinical and histopathological presentation

2013 ◽  
Vol 88 (2) ◽  
pp. 260-262 ◽  
Author(s):  
Adrilena Lopes Adriano ◽  
Paula Azevedo Borges Leal ◽  
Marcelle Parente Breckenfeld ◽  
Igor dos Santos Costa ◽  
Clarisse Almeida ◽  
...  
Keyword(s):  
Male Patient ◽  
Clinical Manifestation ◽  
Unusual Presentation ◽  
Solitary Lesion ◽  
Meglumine Antimoniate ◽  
Histopathological Findings ◽  
Histological Sections ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis ◽  
Extended Duration

We report a case of an unusual presentation of American Tegumentary Leishmaniasis involving a male patient with a solitary lesion on the ear lobe, persisting with minimal increase for at least six months without ulceration or related symptoms. The histological sections showed epithelial atrophy and a large number of structures consistent with Leishmania sp. amastigotes within macrophages. Treatment commenced with meglumine antimoniate resulting in regression of the condition. This report is of importance given the unusual clinical manifestation and histopathological findings in this case and the fact that there was low correlation with the extended duration of the disease.

scholarly journals Alterations in Evoked Otoacoustic Emissions by the Use of Meglumine Antimoniate in American Tegumentary Leishmaniasis Patients

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0168492
Author(s):  
Débora Cristina de Oliveira Bezerra ◽  
Renata Oliveira de Barcelos ◽  
Ellen Carvalho de Castro ◽  
Claudia Cristina Jardim Duarte ◽  
Raquel de Vasconcellos Carvalhaes Oliveira ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Clinical features and therapeutic response in adult and pediatric patients with American tegumentary leishmaniasis in Rio de Janeiro

2019 ◽  
Author(s):  
Tatiana C R Senna ◽  
Maria Inês F Pimentel ◽  
Liliane F A Oliveira ◽  
Marcelo R Lyra ◽  
Mauricio N Saheki ◽  
...  
Keyword(s):  
Clinical Features ◽  
Rio De Janeiro ◽  
Pediatric Patients ◽  
Therapeutic Response ◽  
Age Groups ◽  
Healing Time ◽  
The Body ◽  
Reference Centre ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Abstract Background American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis. Methods A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients. Results The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023). Conclusions This study adds to the body of knowledge on differences that exist between different age groups in ATL.

scholarly journals PHLEBOTOMINE SANDFLIES IN RURAL LOCATIONS IN THE STATE OF PARANA, SOUTHERN BRAZIL

2013 ◽  
Vol 55 (6) ◽  
pp. 407-410 ◽  
Author(s):  
Simone Cristina Castanho Sabaini de Melo ◽  
Wilsandrei Cella ◽  
Rubens Massafera ◽  
Natalia Maria Maciel Guerra Silva ◽  
Reinaldo Marqui ◽  
...  
Keyword(s):  
Rural Areas ◽  
Domestic Animal ◽  
The State ◽  
Southern Brazil ◽  
Environmental Characteristics ◽  
Animal Shelters ◽  
Rural Villages ◽  
Tegumentary Leishmaniasis ◽  
Phlebotomine Sandflies ◽  
American Tegumentary Leishmaniasis

SUMMARY This study reports the fauna and frequency of sandflies in domestic animal shelters, residences and other ecotopes in rural areas of the municipality of Bandeirantes, Paraná State. Sandflies were collected twice in eight rural villages by using Falcon traps from 8pm to 6am in 2008. In these localities 4,790 sandflies were collected, which were represented by ten sandfly species, prevailing of Nyssomyia neivai and Nyssomyia whitmani species. It was observed that animal shelters are the domestic ecotopes where there is the greatest frequency of these insects. The localities where the collections were made had the environmental characteristics that allow the persistence of transmission of parasites from the American tegumentary leishmaniasis. Although the fauna and the behavior of sandflies species are similar in different localities, the method of controlling these insects should be adjusted to the environmental characteristics of each one of the most diverse endemic areas of American tegumentary leishmaniasis in the municipalities of Paraná State.

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