SENSITIVITY OF LEISHMANIA BRAZILIENSIS PROMASTIGOTES TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IS HIGHER THAN THAT OF OTHER LEISHMANIA SPECIES AND CORRELATES WITH RESPONSE TO THERAPY IN AMERICAN TEGUMENTARY LEISHMANIASIS

2007 ◽  
Vol 93 (3) ◽  
pp. 688-693 ◽  
Author(s):  
Rilza B. Gayoso Azeredo-Coutinho ◽  
Sergio C. F. Mendonça ◽  
Heather Callahan ◽  
Andréia C. Portal ◽  
Max Grögl
Keyword(s):  
Leishmania Species ◽  
Response To Therapy ◽  
Leishmania Braziliensis ◽  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

scholarly journals American tegumentary leishmaniasis: an uncommon clinical and histopathological presentation

2013 ◽  
Vol 88 (2) ◽  
pp. 260-262 ◽  
Author(s):  
Adrilena Lopes Adriano ◽  
Paula Azevedo Borges Leal ◽  
Marcelle Parente Breckenfeld ◽  
Igor dos Santos Costa ◽  
Clarisse Almeida ◽  
...  
Keyword(s):  
Male Patient ◽  
Clinical Manifestation ◽  
Unusual Presentation ◽  
Solitary Lesion ◽  
Meglumine Antimoniate ◽  
Histopathological Findings ◽  
Histological Sections ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis ◽  
Extended Duration

We report a case of an unusual presentation of American Tegumentary Leishmaniasis involving a male patient with a solitary lesion on the ear lobe, persisting with minimal increase for at least six months without ulceration or related symptoms. The histological sections showed epithelial atrophy and a large number of structures consistent with Leishmania sp. amastigotes within macrophages. Treatment commenced with meglumine antimoniate resulting in regression of the condition. This report is of importance given the unusual clinical manifestation and histopathological findings in this case and the fact that there was low correlation with the extended duration of the disease.

scholarly journals Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis

2020 ◽  
Vol 14 (2) ◽  
pp. e0008029 ◽  
Author(s):  
Jéssica Cristina dos Santos ◽  
Valéria Bernadete Leite Quixabeira ◽  
Muriel Vilela Teodoro Silva ◽  
Michelle S. M. A. Damen ◽  
Kiki Schraa ◽  
...  
Keyword(s):  
Immune Response ◽  
Genetic Variation ◽  
New World ◽  
Leishmania Species ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

scholarly journals Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions

2018 ◽  
Vol 51 (6) ◽  
pp. 769-780 ◽  
Author(s):  
Jamyra Iglesias Cataldo ◽  
Fátima Conceição-Silva ◽  
Liliane de Fátima Antônio ◽  
Armando de Oliveira Schubach ◽  
Mauro Célio de Almeida Marzochi ◽  
...  
Keyword(s):  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Evaluation of antigens from various Leishmania species in a Western blot for diagnosis of American tegumentary leishmaniasis.

2002 ◽  
Vol 66 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Cely Cristina Martins Gonçalves ◽  
Benício Alves De Abreu Filho ◽  
Karoline Rocha Maia ◽  
Rafael Costacurta ◽  
José Vitor Jankevicius ◽  
...  
Keyword(s):  
Western Blot ◽  
Leishmania Species ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Intestinal helminth coinfection is associated with mucosal lesions and poor response to therapy in American tegumentary leishmaniasis

Acta Tropica ◽  
2016 ◽  
Vol 154 ◽  
pp. 42-49 ◽  
Author(s):  
Rilza Beatriz G. Azeredo-Coutinho ◽  
Maria Inês Pimentel ◽  
Graziela Maria Zanini ◽  
Maria F. Madeira ◽  
Jamyra Iglesias Cataldo ◽  
...  
Keyword(s):  
Poor Response ◽  
Response To Therapy ◽  
Intestinal Helminth ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis ◽  
Mucosal Lesions

scholarly journals Multiclonal Leishmania braziliensis Population Structure and Its Clinical Implication in a Region of Endemicity for American Tegumentary Leishmaniasis

2004 ◽  
Vol 72 (1) ◽  
pp. 508-514 ◽  
Author(s):  
A. Schriefer ◽  
A. L. F. Schriefer ◽  
A. Góes-Neto ◽  
L. H. Guimarães ◽  
L. P. Carvalho ◽  
...  
Keyword(s):  
Population Structure ◽  
Northeastern Brazil ◽  
Leishmania Braziliensis ◽  
Disease Manifestation ◽  
Disease Spectrum ◽  
Tegumentary Leishmaniasis ◽  
Significant Difference ◽  
Global Positioning ◽  
American Tegumentary Leishmaniasis ◽  
Strain Polymorphism

ABSTRACT In Corte de Pedra (CP), northeastern Brazil, Leishmania braziliensis causes three distinct forms of American tegumentary leishmaniasis (ATL). To test the hypothesis that strain polymorphism may be involved in this disease spectrum and accurately characterize the parasite population structure in CP, we compared one L. major, two non-CP L. braziliensis, one CP L. amazonensis, and 45 CP L. braziliensis isolates, obtained over a 10-year period from localized cutaneous, mucosal, and disseminated leishmaniasis patients, with randomly amplified polymorphic DNA (RAPD). Electrophoretic profiles were mostly unique across species. All typing protocols revealed polymorphism among the 45 CP L. braziliensis isolates, which displayed eight different RAPD patterns and greater than 80% overall fingerprint identity, attesting to the adequacy of the tools to assess strain variability in CP's geographically limited population of parasites. The dendrogram based on the sum of RAPD profiles of each isolate unveiled nine discrete typing units clustered into five clades. Global positioning showed extensive overlap of these clades in CP, precluding geographic sequestration as the mechanism of the observed structuralization. Finally, all forms of ATL presented a statistically significant difference in their frequencies among the clades, suggesting that L. braziliensis genotypes may be accompanied by specific disease manifestation after infection.

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