American tegumentary leishmaniasis in Brazil: a critical review of the current therapeutic approach with systemic meglumine antimoniate and short‐term possibilities for an alternative treatment

2019 ◽  
Vol 24 (4) ◽  
pp. 380-391 ◽  
Author(s):  
Sílvia H. Carvalho ◽  
Frédéric Frézard ◽  
Neila P. Pereira ◽  
Alexandre S. Moura ◽  
Lucinéia M. Q. C. Ramos ◽  
...  
Keyword(s):  
Alternative Treatment ◽  
Critical Review ◽  
Therapeutic Approach ◽  
Short Term ◽  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

scholarly journals American tegumentary leishmaniasis: an uncommon clinical and histopathological presentation

2013 ◽  
Vol 88 (2) ◽  
pp. 260-262 ◽  
Author(s):  
Adrilena Lopes Adriano ◽  
Paula Azevedo Borges Leal ◽  
Marcelle Parente Breckenfeld ◽  
Igor dos Santos Costa ◽  
Clarisse Almeida ◽  
...  
Keyword(s):  
Male Patient ◽  
Clinical Manifestation ◽  
Unusual Presentation ◽  
Solitary Lesion ◽  
Meglumine Antimoniate ◽  
Histopathological Findings ◽  
Histological Sections ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis ◽  
Extended Duration

We report a case of an unusual presentation of American Tegumentary Leishmaniasis involving a male patient with a solitary lesion on the ear lobe, persisting with minimal increase for at least six months without ulceration or related symptoms. The histological sections showed epithelial atrophy and a large number of structures consistent with Leishmania sp. amastigotes within macrophages. Treatment commenced with meglumine antimoniate resulting in regression of the condition. This report is of importance given the unusual clinical manifestation and histopathological findings in this case and the fact that there was low correlation with the extended duration of the disease.

scholarly journals Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions

2018 ◽  
Vol 51 (6) ◽  
pp. 769-780 ◽  
Author(s):  
Jamyra Iglesias Cataldo ◽  
Fátima Conceição-Silva ◽  
Liliane de Fátima Antônio ◽  
Armando de Oliveira Schubach ◽  
Mauro Célio de Almeida Marzochi ◽  
...  
Keyword(s):  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

scholarly journals Alterations in Evoked Otoacoustic Emissions by the Use of Meglumine Antimoniate in American Tegumentary Leishmaniasis Patients

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0168492
Author(s):  
Débora Cristina de Oliveira Bezerra ◽  
Renata Oliveira de Barcelos ◽  
Ellen Carvalho de Castro ◽  
Claudia Cristina Jardim Duarte ◽  
Raquel de Vasconcellos Carvalhaes Oliveira ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Meglumine Antimoniate ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Clinical features and therapeutic response in adult and pediatric patients with American tegumentary leishmaniasis in Rio de Janeiro

2019 ◽  
Author(s):  
Tatiana C R Senna ◽  
Maria Inês F Pimentel ◽  
Liliane F A Oliveira ◽  
Marcelo R Lyra ◽  
Mauricio N Saheki ◽  
...  
Keyword(s):  
Clinical Features ◽  
Rio De Janeiro ◽  
Pediatric Patients ◽  
Therapeutic Response ◽  
Age Groups ◽  
Healing Time ◽  
The Body ◽  
Reference Centre ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Abstract Background American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis. Methods A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients. Results The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023). Conclusions This study adds to the body of knowledge on differences that exist between different age groups in ATL.

Wilderness Camping as a Therapy for Emotionally Disturbed Children: A Critical Review

1979 ◽  
Vol 45 (8) ◽  
pp. 628-635 ◽  
Author(s):  
E. Sandra Byers
Keyword(s):  
Critical Review ◽  
Emotionally Disturbed ◽  
Evaluation Research ◽  
Disturbed Child ◽  
Short Term ◽  
Minimal Support ◽  
Therapeutic Program ◽  
Good Setting ◽  
Therapeutic Camping

The wilderness camp has been described as a particularly good setting for treatment of the emotionally disturbed child. This article summarizes the current literature on therapeutic camping, including the nature of existing programs, rationales for the superiority of camping as a therapeutic program, and evaluation of existing programs. The results of program evaluation research reported in the literature provide only minimal support for any particular effectiveness ascribed to therapeutic camping in terms of either short term or long term therapeutic outcome. This is seen to be largely due to inadequate investigation of the process and/or the outcome of therapeutic camping.

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