scholarly journals COMPARATIVE ANALYSIS OF TISSULAR RESPONSE AFTER ABDOMINAL WALL REPAIR USING POLYPROPYLENE MESH AND BOVINE PERICARDIUM MESH

2021 ◽  
Vol 34 (3) ◽  
Author(s):  
Marina BAKRI ◽  
Fernanda Christo LOVATO ◽  
Géssica de Mattos DIOSTI ◽  
Yorgos Luiz Santos de Graça SALLES ◽  
Paulo Henrique Brites MOREIRA ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Inflammatory Process ◽  
Acute Inflammation ◽  
Giant Cells ◽  
Bovine Pericardium ◽  
Recurrence Rates ◽  
Abdominal Wall Repair ◽  
Alternative Materials ◽  
Mesh Method

ABSTRACT Background: The use of polypropylene meshes for surgical repair of the abdominal wall contributes to a reduction of the of recurrence rates of hernias or defects. However, its intra-abdominal use comes along with the formation of adhesions and several complications. The study and the search for alternative materials, including bovine pericardium, have been regarded as an option for the correction and treatment of resulting hernias with better adaptations and effectiveness. Aim: Evaluating the inflammatory process of the bovine pericardium in comparison with the inflammatory process of synthetic polypropylene mesh. Method: Bovine pericardium mesh and polypropylene mesh were placed, both on the same animal. The first group had the mesh removed for analysis on day 20, and the second group on day 40. The variables congestion, granulation, giant cells, necrosis, acute inflammation, chronic inflammation and collagen were analyzed. Results: All variables were found in greater numbers as a response to the polypropylene mesh, except for the collagen, which, on day 40, was greater in response to the bovine pericardium mesh. Conclusion: The data in this study suggest that there is less inflammatory reaction in response to bovine pericardium mesh when compared to polypropylene mesh.

Intestine Submucosa and Polypropylene Mesh for Abdominal Wall Repair in Dogs

1996 ◽  
Vol 60 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Kevin M. Clarke ◽  
Gary C. Lantz ◽  
S.Kathleen Salisbury ◽  
Stephen F. Badylak ◽  
Michael C. Hiles ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Abdominal Wall Repair

scholarly journals REPAIR OF ABDOMINAL WALL DEFECTS WITH ACELLULAR BOVINE PERICARDIUM MATRIX - A MULTICENTER PROSPECTIVE STUDY

2021 ◽  
Author(s):  
Luiz F Frascino ◽  
Jonas D.C. Severi ◽  
Fernanda R.F. Lorenzzato ◽  
Hamilton L.X. Funes
Keyword(s):  
Abdominal Wall ◽  
Systemic Reaction ◽  
Bovine Pericardium ◽  
Abdominal Hernia ◽  
Abdominal Wall Defects ◽  
Recurrence Rates ◽  
New Era ◽  
Acellular Matrix ◽  
Multicenter Prospective Study ◽  
Conceptual Evolution

Background: The association of prosthetic meshes in the abdominal wall repair , reducing the recurrence rates in an impactful way, has become an almost mandatory routine for the success of these surgeries. After decades using non-biological synthetic implants, from the 90s onwards biological acellular membranes of animal or human origin were introduced , beginning a new era in abdominal wall defects correction . Methods: Thirty patients underwent repair for different abdominal wall deformities, with acellular matrices of bovine pericardium, in a total of 40 anatomically individualized implants. The median follow-up was 22 months, with patients evaluated clinically and radiologically. In three cases, biopsies of the implanted areas were performed, allowing histological analysis of the material. Results: There was no recurrence of hernias in any of the cases, both clinically and radiologically. There was also no record of hematomas, infections or any phenomenon of a local or systemic reaction nature. Radiologically, it was not possible to visualize the matrices at the implantation site in any of the analysed postoperative periods. Biopsies showed important tissue neoformation replacing the implanted membranes, with important deposition of collagen, normal-looking cellularized tissue, and absence of foreign body reactions. Conclusions: The analysed matrices showed similarity to other biological membranes described in the international literature. Representing an important update and conceptual evolution, biological matrices must be incorporated into the therapeutic arsenal in abdominal wall repairs. Key Words: Biological prosthetic mesh; Biological acellular matrix; Acellular bovine pericardium matrix; Abdominal hernia; Ventral hernia repair;

Influence of polyglactin-coating on functional and morphological parameters of polypropylene-mesh modifications for abdominal wall repair

Biomaterials ◽  
1999 ◽  
Vol 20 (7) ◽  
pp. 613-623 ◽  
Author(s):  
U. Klinge ◽  
B. Klosterhalfen ◽  
M. Müller ◽  
M. Anurov ◽  
A. Öttinger ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Morphological Parameters ◽  
Abdominal Wall Repair

Niche Reconstructive Techniques for Complex Abdominal Wall Reconstruction: A Review

2014 ◽  
Vol 80 (4) ◽  
pp. 327-334 ◽  
Author(s):  
Gloria R. Sue ◽  
Deepak Narayan
Keyword(s):  
Abdominal Wall ◽  
Abdominal Wall Reconstruction ◽  
Surgical Techniques ◽  
Abdominal Wall Defects ◽  
Recurrence Rates ◽  
Surgical Morbidity ◽  
Abdominal Wall Repair ◽  
Surgical Methods ◽  
Latissimus Dorsi Myocutaneous Flap ◽  
Reconstructive Techniques

Abdominal wall defects resulting from recurrent hernias, trauma, and radiation necrosis are difficult and challenging to repair given the high rates of recurrence and surgical morbidity. Complex abdominal wall defects often require the transposition of autologous material to bridge the fascial gap. We present a review of niche reconstructive techniques that have been used in complex abdominal wall repair. The specific techniques reviewed include use of delayed and tunneled pedicled tensor fascia lata myofascial flap, de-epithelialized flap closure, free latissimus dorsi myocutaneous flap with or without innervation, and abdominal wall transplant. These niche surgical techniques have great potential to reduce recurrence rates when used in the proper setting for complex abdominal wall reconstruction. More studies are needed to evaluate the relative use of these techniques with the more widely established surgical methods of reconstruction.

scholarly journals Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

2009 ◽  
Vol 24 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Márcia Vaz ◽  
Rodrigo Ketzer Krebs ◽  
Eduardo Neubarth Trindade ◽  
Manoel Roberto Maciel Trindade
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Type I Collagen ◽  
Giant Cells ◽  
Type Iii Collagen ◽  
Type I ◽  
Mesh Implantation ◽  
Time Required ◽  
Post Implantation ◽  
Time Point

PURPOSE: This study assessed the collagen deposition and correlated it with local inflammatory responses to evaluate the length of time required for fibroplasia when polypropylene meshes are used to repair incisional abdominal wall hernias in rats. METHODS: Thirty-six male Wistar rats underwent longitudinal resection of a peritoneal and musculoaponeurotic tissue segment (3x2 cm) of the abdominal wall followed by defect reconstruction with polypropylene mesh bridging over aponeurosis. The animals were divided into 6 groups according to the time points for the analysis of fibroplasia: 1, 2, 3, 7, 21 and 30 days post-implantation. Animals were sacrificed at each time point, and the site where the polypropylene mesh was implanted was evaluated histologically to assess inflammatory response and percentage of collagen using computer-assisted videomorphometry. RESULTS: Total collagen was found at the mesh site on the 3rd day post-implantation, and increased progressively on all subsequent days up to the 21st day, when it reached its highest percentage (p<0.001). Type III collagen increased progressively from the 3rd to the 21st days, when it reached its highest percentage (p<0.001); on the 30th day, it decreased significantly (p>0.001). Type I collagen was first found between the 7th and 21st days; it reached its highest percentage on the 21st day and then remained stable until the 30th day. The type I to type III collagen ratio increased significantly and progressively up to the 30th day (p<0.001). Neutrophils were found at the mesh site from the 1st to the 21st day post-implantation. Macrophages, giant cells and lymphocytes were seen on the 2nd day. Thirty days after mesh implantation, neutrophils disappeared, but the percentages of macrophages, giant cells and lymphocytes remained stable (p<0.001). CONCLUSIONS: This study showed that total collagen was first seen on the 3rd day post-implantation, with a higher percentage of type I collagen at the last observational time point. The prolonged healing inflammatory response and the persistence of chronic inflammation surrounding to the mesh did not affect the length of time required for fibroplasia.

Platelet Rich Fibrin Augmented Versus Non-Augmented Glycerolized Bovine Pericardium and Polypropylene Mesh for Repairing of Large Abdominal Wall Defects

2020 ◽  
Vol 3 (2) ◽  
pp. 7
Author(s):  
M. H. El-Husseiny ◽  
El-Maghraby H. M ◽  
Alakraa A. M
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Autologous Blood ◽  
Healing Process ◽  
Inflammatory Cells ◽  
Bovine Pericardium ◽  
Abdominal Wall Defects ◽  
Gray Scale ◽  
Platelet Rich Fibrin ◽  
Post Implantation

This study aimed to evaluate the use of glycerolized bovine pericardium (GBP) compared to polypropylene mesh (PPM) in repairing of large abdominal wall defects in animal model, and to investigate the role of platelet rich fibrin (PRF) in promoting this repair. Fresh bovine pericardium collected from local abattoir were processed and preserved in 99.5 percent glycerol. PRF matrix was harvested from fresh autologous blood (10 ml) after centrifugation. Full-thickness, mid-ventral abdominal wall defects (6 × 10 cm) were surgically created in 36 healthy goats (9 goats/group) and were repaired with an equal size of GBP, PPM, GBP-PRF, or PPM-PRF. Qualitative and gray scale quantitative ultrasonography were adopted at day 1, 1, 2, 3, 4, 8 and 12 weeks post-implantation. Three goats per group were slaughtered at 4, 8 and 12 weeks post-implantation for further gross, histopathological and tensiometric (tensile strength, load at failure and strain percent) evaluations. Ultrasonography revealed significant (P˂ 0.05) improvement of implant gray scale, low subcutaneous edema and reduction of skin implant distance in PRF-augmented groups. Besides, a substantial improvement of connective tissue covering, implant incorporation, new blood vessels formation, and reduction of the inflammatory cells infiltrations were observed. Tensiometric parameters were improved in GBP-PRF group compared to the other groups. In conclusion, the obtained results not only proved the superiority of GBP over PPM, but also the advantage of PRF-augmented over non-augmented implants in treatment of large abdominal wall defects. Ultrasonographic analysis provided a satisfactory tool to evaluate the healing process of the abdominal wall defects.

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