scholarly journals Ion mobility spectrometry: the diagnostic tool of third millennium medicine

2018 ◽  
Vol 64 (9) ◽  
pp. 861-868 ◽  
Author(s):  
Katiuska I. Romero ◽  
Roberto Fernandez-Maestre
Keyword(s):  
Volatile Compounds ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Diagnostic Tool ◽  
Biological Samples ◽  
Low Cost ◽  
Bronchial Carcinoma ◽  
Chronic Obstructive ◽  
Non Invasive ◽  
Compact Size

SUMMARY Ion mobility spectrometry (IMS) is a fast, low cost, portable, and sensitive technique that separates ions in a drift tube under the influence of an electric field according to their size and shape. IMS represents a non-invasive and reliable instrumental alternative for the diagnosis of different diseases through the analysis of volatile metabolites in biological samples. IMS has applications in medicine in the study of volatile compounds for the non-invasive diagnose of bronchial carcinoma, chronic obstructive pulmonary disease, and other diseases analysing breath, urine, blood, faeces, and other biological samples. This technique has been used to study complex mixtures such as proteomes, metabolomes, complete organisms like bacteria and viruses, monitor anaesthetic agents, determine drugs, pharmaceuticals, and volatile compounds in human body fluids, and others. Pharmaceutical applications include analysis of over-the-counter-drugs, quality assessment, and cleaning verification. Medical practice needs non-invasive, robust, secure, fast, real-time, and low-cost methods with high sensitivity and compact size instruments to diagnose different diseases and IMS is the diagnostic tool that meets all these requirements of the Medicine of the future.

scholarly journals Ion Mobility–Mass Spectrometry for Bioanalysis

Separations ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 33
Author(s):  
Xavier Garcia ◽  
Maria del Mar Sabaté ◽  
Jorge Aubets ◽  
Josep Maria Jansat ◽  
Sonia Sentellas
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Biological Samples ◽  
Ion Mobility Mass Spectrometry ◽  
Exogenous Compounds ◽  
Analytical Separation

This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characterization of compounds based on their mobility. IMS has been used in several areas taking advantage of its orthogonality with other analytical separation techniques, such as liquid chromatography, gas chromatography, capillary electrophoresis, or supercritical fluid chromatography. Bioanalysis is not one of the areas where IMS has been more extensively applied. However, over the last years, the interest in using this approach for the analysis of biological samples has clearly increased. This paper introduces the reader to the principles controlling the separation in IMS and reviews recent applications using this technique in the field of bioanalysis.

scholarly journals Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry

Micromachines ◽  
2019 ◽  
Vol 10 (5) ◽  
pp. 286 ◽  
Author(s):  
Li ◽  
Yun ◽  
Du ◽  
Guo ◽  
Zeng ◽  
...  
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
High Field ◽  
Mass Spectra ◽  
Low Cost ◽  
Ion Source ◽  
Resolving Power ◽  
Asymmetric Waveform ◽  
Negative Corona ◽  
Liga Technology

A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a diameter of 400 μm, were connected to the negative high voltage and ground, respectively. A negative corona and glow discharge were realized. For acetone with a density of 99.7 ppm, ethanol with a density of 300 ppm, and acetic ether with a density of 99.3 ppm, the sample gas was ionized by the needle-to-cylinder chip and the ions were detected by an LTQ XL™ (Thermo Scientific Corp.) mass spectrometer. The mass spectra show that the ions are mainly the protonated monomer, the proton bound dimer, and an ion-H2O molecule cluster. In tandem with a FAIMS system, the FAIMS spectra show that the resolving power increases with an increase in the RF voltage. The obtained experimental results showed that the micro needle-to-cylinder chip may serve as a miniature, low cost and non-radioactive ion source for FAIMS.

Using probabilistic relational learning to support bronchial carcinoma diagnosis based on ion mobility spectrometry

2010 ◽  
Vol 13 (2) ◽  
pp. 83-93 ◽  
Author(s):  
Marc Finthammer ◽  
Christoph Beierle ◽  
Jens Fisseler ◽  
Gabriele Kern-Isberner ◽  
Jörg Ingo Baumbach
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Relational Learning ◽  
Bronchial Carcinoma

Ultrasonographic assessment of ophthalmic diseases in low-income countries

2018 ◽  
Vol 48 (4) ◽  
pp. 294-297 ◽  
Author(s):  
Amar Pujari ◽  
Deepa R Swamy ◽  
Rashmi Singh ◽  
Ritika Mukhija ◽  
Rohan Chawla ◽  
...  
Keyword(s):  
Low Income ◽  
Diagnostic Tool ◽  
Low Cost ◽  
Anterior Segment ◽  
Posterior Segment ◽  
Low Income Countries ◽  
Patient Volume ◽  
Non Invasive ◽  
Ophthalmic Diseases ◽  
Ultrasonographic Assessment

We undertook a study between December 2016 and February 2017 on 1637 of 2101 patients with clearly documented findings. These underwent ocular B-scan ultrasonography (USG). Their ages were in the range of 10 days to 92 years; among these patients, 921 (56.26%) were male and 224 (13.68%) were children. Among the adults, 669 (40.86%) patients had anterior segment and 636 (38.85%) had posterior segment pathology. In addition, there were 108 (6.59%) with orbital pathology. Our experience is that USG is an effective, quick, low-cost and non-invasive diagnostic tool for the diagnosis of various ocular and orbital conditions in high patient volume centres (including children and adults) especially where resources are limited.

Sign in / Sign up

Export Citation Format

Share Document