scholarly journals PLUMMER VINSON SYNDROME - is it common in males?

2015 ◽  
Vol 52 (3) ◽  
pp. 250-252 ◽  
Author(s):  
Satvinder Singh BAKSHI
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Gastrointestinal Malignancies ◽  
Esophageal Web ◽  
Plummer Vinson Syndrome ◽  
Increased Risk ◽  
Male Patients ◽  
Males And Females

BackgroundPlummer-Vinson syndrome is characterized by a triad of dysphagia, iron deficiency anemia and esophageal web. Most of the patients are middle aged women in the fourth to seventh decade of life.ObjectiveVery few cases of Plummer-Vinson syndrome affecting males have been reported. Here we report a series of male patients found to be suffering from Plummer-Vinson syndrome.MethodsFive males presented to us with dysphagia and fatigue of various durations, from April to August, 2012.ResultsThese patients were found to have iron deficiency anemia and esophageal web on subsequent investigations and were treated successfully with oral iron therapy.ConclusionPlummer-Vinson syndrome is common in both males and females and can be successfully treated with oral iron therapy. The patients have an increased risk of developing gastrointestinal malignancies and should be thoroughly evaluated for the same.

scholarly journals A Rare Case Report on Plummer-Vinson Syndrome with a Complication of Oral Cancer in a South-Asian Woman

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ayisha Ayisha ◽  
Sheema Masood Ali
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Iron Deficiency ◽  
Cell Carcinoma ◽  
Iron Deficiency Anemia ◽  
Squamous Cell ◽  
Whole Body ◽  
Deficiency Anemia ◽  
Plummer Vinson Syndrome ◽  
Increased Risk

Plummer-Vinson syndrome (PVS), also called "Paterson-Brown-Kelly syndrome“, is a rare medical syndrome generally affecting middle-aged women. Iron deficiency anemia is the prime etiological factor and other probable factors include malnutrition, genetic predisposition, or autoimmune processes characterized by three distinctive features: iron deficiency anemia, dysphagia, and esophageal web. The dysphagia is generally painless and intermittent or progressive over years, restricted to solids, and associated with weight loss. The exact pathogenesis of PVS is still indistinguishable, but it is interconnected with iron deficiency anemia. Plummer-Vinson syndrome, if left untreated, carries an increased risk of developing squamous cell carcinoma of the upper alimentary tract.In this case report, a 40-year-old female patient presented long-standing dysphagia for months, which progressively developed to postcricoid squamous cell carcinoma by the time she approached to medical treatment. Diagnosis was confirmed through laboratory tests, showing iron deficiency anemia and whole-body positron emission tomography-computed tomography (PET-CT) presenting squamous cell carcinoma in postcricoid region (hypopharynx).

Anemia ferropénica crónica: síndrome de Plummer-Vinson (Paterson-Brown-Kelly)

2021 ◽  
Vol 64 (2) ◽  
pp. 22-25
Author(s):  
Adriana Zapata González ◽  
María Elena Uc Miam ◽  
Felipe Irineo Hernández Rosales ◽  
Alberto Mandujano González ◽  
Karime Berenice Ramos Santos
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Clinical History ◽  
Deficiency Anemia ◽  
Precancerous Condition ◽  
Esophageal Web ◽  
Squamous Cell Esophageal Cancer ◽  
Plummer Vinson Syndrome ◽  
History Of ◽  
First Contact

Plummer-Vinson syndrome (Paterson-Brown-Kelly) is a rare entity, characterized by dysphagia, esophageal web formation, and iron deficiency anemia. We present the case of a 46-year-old woman with a clinical history of iron deficiency anemia who subsequently presents dysphagia and odynophagia. A subcricoid web that was successfully broken with the endoscope was found. First contact doctors should be familiar with the symptoms of Plummer-Vinson syndrome, and take them into account, when addressing a patient with the classic triad. Since the syndrome is a precancerous condition with high malignant potential, early diagnosis and treatment is of utmost importance for better prognosis. Keywords: Plummer-Vinson syndrome; chronic iron deficiency anemia; esophageal membrane; squamous cell esophageal cancer; Paterson-Brown-Kelly syndrome.

scholarly journals A Case of Plummer-Vinson Syndrome Esophageal Web Dysphagia treated by Dilatation with Cuffed Endotracheal Tube

2011 ◽  
Vol 2 (3) ◽  
pp. 161-165 ◽  
Author(s):  
Sudhir Naik ◽  
Sarika S Naik ◽  
S Ravishankara ◽  
MC Shivakumar ◽  
Mohan K Appaji
Keyword(s):  
Iron Deficiency ◽  
Blood Transfusion ◽  
Endotracheal Tube ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
White Female ◽  
Barium Swallow ◽  
Cuffed Endotracheal Tube ◽  
Esophageal Web ◽  
Plummer Vinson Syndrome

ABSTRACT Background/objectives Plummer-Vinson syndrome also known as sideropenic dysphagia is a disease characterized by chronic iron-deficiency anemia, dysphagia and esophageal web. It commonly affects white female in the 4th to 7th decade. Most of the dysphagia and iron deficiency can be treated by iron supplementation and rarely web dilatation is needed. Setting Department of ENT, Head and Neck Surgery and Anesthesia, KVG Medical College, Sullia, Karnataka, India. Case report A 36-year-old female with dysphagia of 10 months and iron-deficiency anemia with a small upper esophageal web seen on upper GI endoscopy and barium swallow. Intervention Conservative line of management with blood transfusion and dilatation of the web with cuffed endotracheal tube. Results A good symptomatic and radiological improvement was seen after blood transfusion and web dilatation with cuffed endotracheal tube. Conclusion Cuffed endotracheal tube dilatation is a better way of managing upper esophageal webs with minimal complications under general anesthesia.

Chronic Iron Deficiency Anemia and Cancer Risk

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 5172-5172 ◽  
Author(s):  
Chia-Jen Liu ◽  
Kuo-Wei Chen ◽  
Yu-Wen Hu ◽  
Ying-Chung Hong ◽  
Yu-Chung Huang ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Cancer Risk ◽  
Iron Deficiency Anemia ◽  
Conflicts Of Interest ◽  
Cancer Development ◽  
Deficiency Anemia ◽  
Initial Manifestation ◽  
Gastrointestinal Malignancies ◽  
Increased Risk ◽  
Risk Of Cancer

Abstract Abstract 5172 Background Iron deficiency anemia (IDA) is a common initial manifestation of gastrointestinal malignancies, but the relationship between chronic IDA and further cancer development is not established. Aims We would like to investigate the cancer risk of chronic IDA over a 10-year period in Taiwan. Methods We enrolled patients with iron deficiency anemia from a nationwide health registry in Taiwan during the period 2000–2009. All patients received at least 2 related examinations and were treated with iron supplement. Since IDA is an initial manifestation of many underlying malignancies, we excluded patients whose cancer developed within 1 year after IDA diagnosis. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of chronic IDA patients to general population. The specific types of cancer were addressed. Results A total of 4, 373 patient with IDA were identified, and 132 (3. 02%) IDA patients developed cancer 1 year after enrollment (SIR 1. 52; 95% confidence interval [CI] 1. 27 – 1. 80, p < 0. 001). The risks of kidney (SIR 5. 47, 95% CI 2. 73 – 9. 78), bladder (SIR 3. 6, 95% CI 1. 64 – 6. 83), liver (SIR 2. 80, 95% CI 1. 82 – 4. 13), and colorectal malignancies (SIR 1. 93, 95% CI 1. 22 – 2. 90) elevated. The risk of hematological malignancies were not increased in current study (SIR 1. 13, 95% CI 0. 31 – 2. 89, p = 0. 758). Conclusions After exclusion of cancer development within the first year, IDA patients still had increased risk of cancer, especially kidney, bladder, liver, and colorectal malignancies. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Case report on Plummer Vinson syndrome

2019 ◽  
Vol 8 (10) ◽  
pp. 2334
Author(s):  
Chanukya Vanam ◽  
Durga Prasad Thammisetty
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
General Medicine ◽  
Deficiency Anemia ◽  
Systemic Effects ◽  
Plummer Vinson Syndrome ◽  
History Of ◽  
Male Patients

Plummer Vinson syndrome or Paterson-Brown-Kelly syndrome is a rare disorder is characterized by a triad of iron deficiency anemia, post-cricoid dysphagia and upper oesophageal web. This is a condition that is hypothesized to occur in people with long-term iron-deficiency anemia. It is more prevalent in females than in male patients. This disorder is characterized by iron deficiency anemia, post-cricoid dysphagia and oesophageal webs, symptoms typically progress over a period of six months and often include other systemic effects such as angular cheilitis, glossitis, and spooning of the fingernails. Here we report a case of 38 years female admitted in general medicine female with complaints of breathlessness and tightness of chest relieving after vomiting and had history of anemia, dysphagia insidious in onset and dysphagia associated with solid food over a year on examination patient was found to be gross pallor, angular cheilitis, spoon-shaped nails of fingers and toes. The lab findings were hemoglobin of 7.8 g/dl, serum ferritin levels 7.23 ng/ml, vitamin B12 175.2 pg/ml and upper oesophageal endoscopy revealed oesophageal web in the post-cricoid region. Treatment of Plummer Vinson syndrome includes iron supplementation followed by endotracheal dilation if necessary.

scholarly journals Plummer-Vinson Syndrome: A Case Report

2011 ◽  
Vol 31 (3) ◽  
pp. 254-256
Author(s):  
DS Gedam ◽  
J Mandliya ◽  
M Verma
Keyword(s):  
Case Report ◽  
Iron Deficiency ◽  
Ethnic Group ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
White Female ◽  
Esophageal Web ◽  
Plummer Vinson Syndrome ◽  
Classical Triad

Plummer-Vinson also known as sideropenic dysphagia is a disease that is characterized by classical triad of iron deficiency anemia, dysphagia and esophageal web. It is known to mostly affect white female mainly, but cases have been reported from other ethnic group in the literature. Treatment is very promising especially when it is not associated with carcinoma. DOI: http://dx.doi.org/10.3126/jnps.v31i3.4259 J Nep Paedtr Soc 2011;31(3): 254-256

scholarly journals Plummer-Vinson syndrome presenting as squamous cell carcinoma of esophagus

2016 ◽  
Vol 07 (02) ◽  
pp. 071-073 ◽  
Author(s):  
Gandhi Lanke ◽  
Pramoda Koduru ◽  
Manoop S. Bhutani
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Deficiency Anemia ◽  
Plummer Vinson Syndrome ◽  
Increased Risk ◽  
Carcinoma Of Esophagus ◽  
Iron Replacement

AbstractPlummer-Vinson syndrome (PVS) also known as Paterson-Brown-Kelly syndrome is a rare syndrome which comprises iron deficiency anemia, dysphagia, and esophageal webs. The pathogenesis of PVS is not clear. Iron deficiency anemia is essential for diagnosis of PVS. If left untreated, there is an increased risk of developing pharyngeal or esophageal cancer in about 10% of patients. There are no strict guidelines for endoscopic surveillance in patients with PVS. Iron replacement can improve dysphagia and potentially lead to regression of esophageal webs. In this case report, we present a patient who had long-standing dysphagia for years which progressed to squamous cell cancer of esophagus by the time she sought medical treatment.

scholarly journals IRON ABSORPTION AND RESPONSE TO ORAL IRON THERAPY IN IRON DEFICIENCY ANEMIA ASSOCIATED TO ASYMPTOMATIC GIARDIASIS.

1993 ◽  
Vol 33 (6) ◽  
pp. 661-661
Author(s):  
Helena U Suzuki ◽  
Mauro B Morais ◽  
Jose N Corral ◽  
Ulisses Fagundes-Neto ◽  
Nelson L Machado
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Absorption ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Oral Iron Therapy

The Treatment of Iron-deficiency Anemia—Palatable but Ineffective Iron Medication

PEDIATRICS ◽  
1963 ◽  
Vol 31 (6) ◽  
pp. 1041-1044
Author(s):  
LOUIS K DIAMOND ◽  
J. LAWRENCE NAIMAN ◽  
DONALD M. ALLEN ◽  
FRANK A. OSKI,
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Oral Iron ◽  
Gastrointestinal Absorption ◽  
Deficiency Anemia ◽  
Therapeutic Effects ◽  
Rapid Rise ◽  
Carbohydrate Complex ◽  
Therapeutic Results

Experience with a new oral iron-carbohydrate complex (Jefron) in the treatment of iron-deficiency anemia shows that the therapeutic results are inferior to those obtainable with ferrous sulfate. Many children showed no response after months of treatment with this drug and when subsequently placed on ferrous sulfate therapy showed a rapid rise in hemoglobin to normal levels. Preliminary studies suggest that poor gastrointestinal absorption may be a factor in the inadequate therapeutic effects.

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