scholarly journals What are the similarities between stress, sudden cardiac death in Gallus gallus and sudden unexpected death in people with epilepsy

2010 ◽  
Vol 68 (5) ◽  
pp. 788-790 ◽  
Author(s):  
Fulvio A Scorza ◽  
Ricardo de Albuquerque ◽  
Ricardo M Arida ◽  
Marly de Albuquerque ◽  
Vera C Terra ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Environmental Factors ◽  
Sudden Death ◽  
Ventricular Arrhythmia ◽  
Cardiac Death ◽  
Broiler Chickens ◽  
Gallus Gallus ◽  
Sudden Death Syndrome ◽  
Sudden Unexpected Death ◽  
Unexpected Death

Individuals with epilepsy are at higher risk of sudden unexpected death in epilepsy (SUDEP), responsible for 7.5% to 17% of all deaths in epilepsy. Many factors are current associated with SUDEP and possible effect of stress and cardiac arrhythmia are still not clear. Sudden death syndrome (SDS) in chickens is a disease characterized by an acute death of well-nourished and seeming healthy Gallus gallus after abrupt and brief flapping of their wings, similar to an epileptic seizure, with an incidence estimated as 0.5 to 5% in broiler chickens. A variety of nutritional and environmental factors have been included: but the exactly etiology of SDS is unknown. Studies had suggested that the hearts of broiler chickens are considerably more susceptible to arrhythmias and stress may induce ventricular arrhythmia and thus, sudden cardiac death. In this way, SDS in Gallus gallus could be an interesting model to study SUDEP.

Could sudden death syndrome (SDS) in chickens (Gallus gallus) be a valid animal model for sudden unexpected death in epilepsy (SUDEP)?

2009 ◽  
Vol 73 (1) ◽  
pp. 67-69 ◽  
Author(s):  
F.A. Scorza ◽  
R. de Albuquerque ◽  
R.M. Arida ◽  
B. Schmidt ◽  
Antonio-Carlos G. de Almeida ◽  
...  
Keyword(s):  
Animal Model ◽  
Sudden Death ◽  
Gallus Gallus ◽  
Sudden Death Syndrome ◽  
Sudden Unexpected Death ◽  
Unexpected Death ◽  
Valid Animal Model

scholarly journals Sudden cardiac death in epilepsy disappoints, but epileptologists keep faith

2016 ◽  
Vol 74 (7) ◽  
pp. 570-573 ◽  
Author(s):  
Fulvio A. Scorza ◽  
Esper A. Cavalheiro ◽  
Jaderson Costa da Costa
Keyword(s):  
Risk Factors ◽  
Sudden Cardiac Death ◽  
Cause Of Death ◽  
Cardiac Death ◽  
Seizure Control ◽  
Intractable Epilepsy ◽  
Sudden Unexpected Death ◽  
Unexpected Death ◽  
Common Cause ◽  
Preventative Measures

ABSTRACT Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in people with intractable epilepsy. Probably, optimization of seizure control will prevent some of these deaths. Briefly, we integrated in this paper some data about the epidemiology, risk factors, etiology, and preventative measures in the management of SUDEP.

Broad-based molecular autopsy: a potential tool to investigate the involvement of subtle cardiac conditions in sudden unexpected death in infancy and early childhood

2015 ◽  
Vol 100 (10) ◽  
pp. 952-956 ◽  
Author(s):  
Montserrat Santori ◽  
Alejandro Blanco-Verea ◽  
Rocio Gil ◽  
Judith Cortis ◽  
Katrin Becker ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Genetic Variants ◽  
Early Onset ◽  
Cardiac Death ◽  
Sudden Unexpected Death ◽  
Unexpected Death ◽  
Molecular Autopsy ◽  
Sudden Unexplained Death ◽  
Unexplained Death ◽  
In Infants And Children

ObjectivesSudden unexplained death in children is a tragic and traumatic event, often worsened when the cause of death cannot be determined. This work aimed to investigate the presence of putative pathogenic genetic variants in a broad spectrum of cardiomyopathy, channelopathy and aortic disease associated genes that may have increased these children's vulnerability to sudden cardiac death.DesignWe performed molecular autopsy of 41 cases of sudden unexplained death in infants and children through massive parallel sequencing of up to 86 sudden cardiac death-related genes. Multiple in silico analyses were conducted together with a thorough review of the literature in order to prioritise the putative pathogenic variants.ResultsA total of 63 variants in 35 cases were validated. The largest proportion of these variants is located within cardiomyopathy genes although this would have been more expected of channelopathy gene variants. Subtle microscopic features of heart tissue may indicate the presence of an early onset cardiomyopathy as a predisposing condition to sudden unexpected death in some individuals.ConclusionsNext-generation sequencing technologies reveal the existence of a wide spectrum of rare and novel genetic variants in sarcomere genes, compared with that of cardiac ion channels, in sudden unexplained death in infants and children. Our findings encourage further investigation of the role of early onset inherited cardiomyopathies and other diseases involving myocardial dysfunction in these deaths. Early detection of variants in these individuals could help to unmask subtle forms of disease within their relatives, who would eventually benefit from better counselling about their genetic history.

Cardiac Dysrhythmias and Sports

PEDIATRICS ◽  
1995 ◽  
Vol 95 (5) ◽  
pp. 786-788
Author(s):  
Keyword(s):  
Sudden Death ◽  
Medical History ◽  
Cardiac Death ◽  
Arrhythmogenic Right Ventricular Dysplasia ◽  
Sudden Onset ◽  
Sudden Unexpected Death ◽  
Qtc Interval ◽  
Unexpected Death ◽  
Ventricular Dysrhythmias ◽  
The Right

Sudden unexpected death during athletic participation is the overriding consideration in advising individuals with dysrhythmias about participation in sports. The incidence of sudden death is 1 to 2 per 200 000 athletes per year and approximately 12 per year in US high school athletes.1 Between 5 and 22% of these deaths occur during sports or physical activities that include basketball, racquetball, jogging, football, soccer, and golf.2 The remainder occur during sedentary activities.2 Another potential risk for the athlete with a dysrhythmia is injury to self or others from syncope or near syncope while playing sports. The leading cause of sudden unexpected cardiac death is hypertrophic cardiomyopathy.1 A dysrhythmia of ventricular or supraventricular origin may be a significant factor in the sudden unexpected death of these individuals.1 Myocarditis is also a cause of sudden cardiac death. Severe dysrhythmia may be a prominent feature of myocarditis even in the absence of significant cardiac dysfunction.1 This diagnosis should be considered in an individual who has a recent sudden onset of a symptomatic dysrhythmia.3 Ventricular dysrhythmias with exercise are a potential cause of death in individuals with arrhythmogenic right ventricular dysplasia (a rare muscle disorder of the right ventricle).1 Sudden death resulting from dysrhythmia can occur with exertion or excitement in individuals who have hereditary syndromes that include prolongation of the QTc interval.3 Sudden death has also been associated with mitral valve prolapse (rarely) and with Wolff-Parkinson-White syndrome.3 MEDICAL HISTORY The patient's medical history is of critical importance. Dysrhythmias may be episodic and not apparent at the time of physical examination.

scholarly journals Histopathological Findings in Sudden Cardiac Death: 5-years Autopsy Experience in a Tertiary Hospital in Bandung, Indonesia

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Gian Nugraha ◽  
Nita Novita ◽  
Hermin Aminah Usman
Keyword(s):  
Sudden Cardiac Death ◽  
Sudden Death ◽  
Cardiac Death ◽  
Coronary Atherosclerosis ◽  
Gastrointestinal Disease ◽  
Histopathological Examination ◽  
Tertiary Hospital ◽  
Unexpected Death ◽  
Cross Sectional ◽  
Histopathological Findings

Background: Sudden death (SD) is a sudden and unexpected death with an unknown cause. However, it has been assummed that the most common causes of sudden deaths are cardiovascular or non-cardiovascular causes such as gastrointestinal disease, respiratory disease, genitourinary disease, epilepsy, and trauma. This study aimed to portray histopathological findings and causes of sudden cardiac death (SCD) cases based on 5 year autopsy experience in a tertiary hospital in Bandung, Indonesia. Methods: This study was a descriptive cross-sectional study exploring causes of SCD from 2015 to 2019 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. All medical records with SCD and histopathology findings were retrieved from September to December 2020. Only cases with histopathological examination results were included.Results: SCD was found in 7 of 16 patients with sudden death. Coronary atherosclerosis was the most common (n=4), followed by myocardial infarction (n=2) and ruptured aortic aneurysm (n=1). Myocarditis and calcific aortic valve diseases were not found.Conclusions: In this study, the most common cause of SCD is coronary atherosclerosis, which is identified mainly in older and male patients.

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