The Role of Environmental Factors in the Causation of Sudden Death in Infants: Two Cases of Sudden Unexpected Death in Two Unrelated Infants Who Were Cared for by the Same Babysitter

2007 ◽  
Vol 0 (0) ◽  
pp. 070917231752001-???
Author(s):  
Bennet I. Omalu ◽  
Jennifer L. Lindner ◽  
Jennifer K. Janssen ◽  
Uche Nnebe-Agumadu ◽  
Victor Weedn
2010 ◽  
Vol 68 (5) ◽  
pp. 788-790 ◽  
Author(s):  
Fulvio A Scorza ◽  
Ricardo de Albuquerque ◽  
Ricardo M Arida ◽  
Marly de Albuquerque ◽  
Vera C Terra ◽  
...  

Individuals with epilepsy are at higher risk of sudden unexpected death in epilepsy (SUDEP), responsible for 7.5% to 17% of all deaths in epilepsy. Many factors are current associated with SUDEP and possible effect of stress and cardiac arrhythmia are still not clear. Sudden death syndrome (SDS) in chickens is a disease characterized by an acute death of well-nourished and seeming healthy Gallus gallus after abrupt and brief flapping of their wings, similar to an epileptic seizure, with an incidence estimated as 0.5 to 5% in broiler chickens. A variety of nutritional and environmental factors have been included: but the exactly etiology of SDS is unknown. Studies had suggested that the hearts of broiler chickens are considerably more susceptible to arrhythmias and stress may induce ventricular arrhythmia and thus, sudden cardiac death. In this way, SDS in Gallus gallus could be an interesting model to study SUDEP.


2010 ◽  
Vol 70 (3) ◽  
pp. 665-670 ◽  
Author(s):  
FA. Scorza ◽  
RM. Cysneiros ◽  
RM. Arida ◽  
VC. Terra ◽  
HR. Machado ◽  
...  

People with epilepsy have an increased risk of dying prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). SUDEP is mainly a problem for patients with chronic uncontrolled epilepsy. The ultimate goal of research in SUDEP is to develop new methods to prevent it and actions other than medical and surgical therapies that could be very useful. Nutritional aspects, i.e., omega-3 fatty acids deficiency, could have an interesting role in this scenario. Some animal and clinical studies have suggested that omega-3 fatty acids could be useful in the prevention and treatment of epilepsy and hence SUDEP. It has been ascertained that the only foods that provide large amounts of omega-3 are seafood (fish and shellfish); however, some fish are contaminated with methylmercury, which may counteract the positive effects of omega-3 fatty acids. Our update review summarises the knowledge of the role of fish consumption on epilepsy research.


Epilepsia ◽  
2012 ◽  
Vol 53 (10) ◽  
pp. 1846-1848 ◽  
Author(s):  
Gabriela Matos ◽  
Laura Bennedsen ◽  
Vanessa A. Garcia ◽  
Fulvio A. Scorza ◽  
Esper A. Cavalheiro ◽  
...  

1988 ◽  
Vol 6 (2) ◽  
pp. 176-187 ◽  
Author(s):  
William C. Wadland ◽  
Bert Keller ◽  
William Jones ◽  
James Chapados

2008 ◽  
Vol 12 (1) ◽  
pp. 208-209 ◽  
Author(s):  
Fulvio A. Scorza ◽  
Ricardo M. Arida ◽  
Marly de Albuquerque ◽  
Esper A. Cavalheiro

2008 ◽  
Vol 93 (12) ◽  
pp. 1048-1053 ◽  
Author(s):  
M A Weber ◽  
M T Ashworth ◽  
R A Risdon ◽  
J C Hartley ◽  
M Malone ◽  
...  

2018 ◽  
Vol 52 (9) ◽  
pp. 868-875 ◽  
Author(s):  
Sonalie Patel ◽  
Mitchell M. Conover ◽  
Golsa Joodi ◽  
Sarah Chen ◽  
Ross J. Simpson ◽  
...  

Background: In Wake County, NC, sudden unexpected death accounts for 10% to 15% of all natural deaths in individuals 18 to 64 years old. Medications such as aspirin, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and β-blockers are recommended in guidelines to reduce cardiovascular events and even sudden death (β-blockers). However, guidelines are often underpracticed, even in high-risk patients, with noted disparities in women. Objective: We assessed the relation between prescription of evidence-based medications and sudden unexpected death in Wake County, NC. Methods: We analyzed 399 cases of sudden unexpected death for the time period March 1, 2013 to February 28, 2015 in Wake County, NC. Medications were assessed from available medical examiner reports and medical records and grouped using the third level of the Anatomical Therapeutic Chemical Classification System (ATC) codes. This study was reviewed and exempt by the University of North Carolina’s institutional review board. Results: Among 126 female and 273 male victims, women were prescribed more medications overall than men (6.5 vs 4.3, P = 0.001); however, the use of guideline-directed therapies was not different between genders in the chronic conditions associated with sudden death. Overall, there was remarkably low use of evidence-based medications. Conclusions: Our findings highlight the need to improve prescribing of evidence-based medications and to further explore the relationship between undertreatment and sudden unexpected death.


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