scholarly journals Association of human herpesvirus 6 infection with exanthem subitum in Belem, Brazil

1995 ◽  
Vol 37 (6) ◽  
pp. 489-492 ◽  
Author(s):  
R. B. de Freitas ◽  
A. C. Linhares ◽  
C. S. Oliveira ◽  
R. H. P. Gusmão ◽  
M. I. S. Linhares
Keyword(s):  
Lymph Node ◽  
Cervical Lymph Node ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Antibody Assay ◽  
Serum Samples ◽  
Exanthem Subitum ◽  
Lymph Node Swelling ◽  
Herpesvirus 6 ◽  
Immunofluorescence Antibody

Recent human herpesvirus 6 (HHV-6) infection was detected in cases of exanthem subitum (ES) involving four children, aged 10 to 24 months, between April and August 1994, in Belém, Brazil. By using the indirect immunofluorescence antibody assay (IFA), significant increases (at least eight times) in antibody concentrations were noted from the acute to the convalescent serum samples, with titers ranging from <1:10/1:80 to <1:10/1:640 (patients 3 and 2, respectively). All children had high fever (over 39ºC) for three days, followed by generalized, maculo-papular skin rash. A physical examination of the children also revealed concomitant, cervical lymph node swelling and tonsillar pharyngitis in two of them.

IDENTIFICATION OF HUMAN HERPESVIRUS-6 AS A CAUSAL AGENT FOR EXANTHEM SUBITUM

The Lancet ◽  
1988 ◽  
Vol 331 (8594) ◽  
pp. 1065-1067 ◽  
Author(s):  
Koichi Yamanishi ◽  
Kimiyasu Shiraki ◽  
Toshio Kondo ◽  
Toshiomi Okuno ◽  
Michiaki Takahashi ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Causal Agent ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
Herpesvirus 6

Characterization of Human Herpesvirus 6 Strains Isolated from Patients with Exanthem Subitum with or without Cutaneous Rash

1992 ◽  
Vol 166 (3) ◽  
pp. 689-689 ◽  
Author(s):  
D. Di Luca ◽  
P. Mirandola ◽  
P. Secchiero ◽  
C. Cermelli ◽  
A. Aleotti ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
Cutaneous Rash ◽  
Herpesvirus 6

scholarly journals Seroprevalence of Antibodies against Human Herpesvirus 6 in the Quebec City Area

1992 ◽  
Vol 3 (4) ◽  
pp. 179-184 ◽  
Author(s):  
Louise Deschênes ◽  
Jean R Joly ◽  
Michel Couillard ◽  
Gilles Richer
Keyword(s):  
Cell Line ◽  
Antibody Titre ◽  
Geometric Mean ◽  
Human Herpesvirus ◽  
Quebec City ◽  
Age Group ◽  
Human Herpesvirus 6 ◽  
Serum Samples ◽  
City Area ◽  
Herpesvirus 6

Seroprevalence of antibodies against human herpesvirus 6 was determined in a sample of 303 randomly selected individuals from the Quebec City area. The influence of different variables on antibody litres was also evaluated. Human herpesvirus 6 was grown in the HSB-2 cell line, and antibody litres were measured by indirect immunofluorescence. Serum samples were collected from 177 females and 126 males ranging in age from two months to 88 years. Ninety-nine per cent (300 of 303) of this population had an antibody titre of at least 1:10, whereas 75% had a titre of at least 1:80. Women had a higher geometric mean litre than men (P=0.06). This difference between sexes varied according to age and became statistically significant in subjects older than 20 years of age (P=0.04). It was found that this difference was attributable to higher antibody litres in women in the 15 to 40 year age group who had previously had children.

Distribution of Antibodies to a Causative Agent of Exanthem Subitum (Human Herpesvirus-6) in Healthy Individuals

PEDIATRICS ◽  
1989 ◽  
Vol 84 (4) ◽  
pp. 675-677
Author(s):  
Tetsushi Yoshikawa ◽  
Sadao Suga ◽  
Yoshizo Asano ◽  
Takehiko Yazaki ◽  
Hiroshi Kodama ◽  
...  
Keyword(s):  
Cord Blood ◽  
Causative Agent ◽  
Human Herpesvirus ◽  
Immunofluorescence Assay ◽  
Healthy Individuals ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
Adolescents And Adults ◽  
Positive Rate ◽  
Herpesvirus 6

The transfer of IgG antibodies to a causative agent of exanthem subitum (human herpesvirus-6) from mother to infant was examined with an indirect immunofluorescence assay. Of 20 mothers, 85% had the antibody more than 1:10, and the significantly higher level of the antibody was found in the cord blood with a positive rate of 95%. A mean ratio of cord blood to maternal antibody titer was 1.63. A total of 301 sera from healthy individuals was examined for the age-specific prevalence of antibody to the virus. In the first 2 months of life, 87% of infants had the antibody; the positive rate and the level of antibody decreased during the first 6 months of life with the lowest positive rate of 6% at 4 to 5 months of age. After 6 months of age, they increased gradually and reached the highest level at 1 year of age with the positive rate of 86%. From 2 years of age, the prevalence of the antibody was almost stable (69% to 76%) and similar to those in adolescents and adults.

scholarly journals IgM Neutralizing Antibody Responses to Human Herpesvirus-6 in Patients with Exanthem Subitum or Organ Transplantation

1992 ◽  
Vol 36 (5) ◽  
pp. 495-506 ◽  
Author(s):  
Sadao Suga ◽  
Tetsushi Yoshikawa ◽  
Yoshizo Asano ◽  
Toshihiko Nakashima ◽  
Takehiko Yazaki ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Human Herpesvirus ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
Herpesvirus 6

Exanthem Subitum and Antibody to Human Herpesvirus-6

1989 ◽  
Vol 159 (4) ◽  
pp. 750-752 ◽  
Author(s):  
K. Ueda ◽  
K. Kusuhara ◽  
M. Hirose ◽  
K. Okada ◽  
C. Miyazaki ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
Herpesvirus 6

scholarly journals Human herpesvirus 6.

1997 ◽  
Vol 10 (3) ◽  
pp. 521-567 ◽  
Author(s):  
D K Braun ◽  
G Dominguez ◽  
P E Pellett
Keyword(s):  
Human Herpesvirus ◽  
Etiologic Agent ◽  
Childhood Illness ◽  
The Other ◽  
Immunocompromised Patients ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
The Central Nervous System ◽  
The Common ◽  
Herpesvirus 6

Human herpesvirus 6 variant A (HHV-6A) and human herpesvirus 6 variant B (HHV-6B) are two closely related yet distinct viruses. These visuses belong to the Roseolovirus genus of the betaherpesvirus subfamily; they are most closely related to human herpesvirus 7 and then to human cytomegalovirus. Over 95% of people older than 2 years of age are seropositive for either or both HHV-6 variants, and current serologic methods are incapable of discriminating infection with one variant from infection with the other. HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. HHV-6B is the etiologic agent of the common childhood illness exanthem subitum (roseola infantum or sixth disease) and related febrile illnesses. These viruses are frequently active and associated with illness in immunocompromised patients and may play a role in the etiology of Hodgkin's disease and other malignancies. HHV-6 is a commensal inhabitant of brains; various neurologic manifestations, including convulsions and encephalitis, can occur during primary HHV-6 infection or in immunocompromised patients. HHV-6 and distribution in the central nervous system are altered in patients with multiple sclerosis; the significance of this is under investigation.

scholarly journals Human herpesvirus-6 viral load and antibody titer in serum samples of patients with multiple sclerosis

2011 ◽  
Vol 44 (4) ◽  
pp. 247-251 ◽  
Author(s):  
Abbas Behzad-Behbahani ◽  
Mohammad Hadi Mikaeili ◽  
Mona Entezam ◽  
Anahita Mojiri ◽  
Gholamreza Yousefi Pour ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Viral Load ◽  
Antibody Titer ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Serum Samples ◽  
Herpesvirus 6
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