Effects of metformin on the glycemic control, lipid profile, and arterial blood pressure of type 2 diabetic patients with metabolic syndrome already on insulin

Background: Metabolic syndrome is a progressive disorder which includes a wide array of disorders i.e. central obesity, hypertension, dyslipidemia, hyperglycemia, and insulin resistance. In patients with metabolic syndrome there is an increased risk of mortality due to coronary heart disease, stroke, vascular dysfunction etc. Obesity is one of the most crucial epidemics of modern times and hormone leptin plays an important role in regulation of body weight and energy balance.Methods: A total of 355 individuals were selected from the OPD, Department of general medicine at ESIC hospital, Okhla and it comprised of 196 males and 159 females suffering from type 2 diabetes mellitus with metabolic syndrome. The data was collected over a year i.e. June 2018 to July 2019. After baseline clinical and anthropometric evaluation, Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS), lipid profile, Insulin (fasting), and leptin levels of the patients were analyzed.Results: Blood sugar fasting, blood sugar post prandial, lipid profile, leptin and insulin levels were increased significantly in female patients as compared to male patients with type 2 diabetic patients and metabolic syndrome.Conclusions: Based on the study results, it was found that leptin correlate significantly with metabolic syndrome and could be used as a biomarker for the early detection of the disease.

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Blood pressure, lipid profile and glycemic control among type-2 diabetic patients in North Kerala

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20212815 ◽

2021 ◽

Author(s):

Liji Kavuparambil ◽

Ashok Kumar Pammi ◽

Jithesh Tharayil Kattil ◽

Santha Kaliyaperumal ◽

Shifa Kollathodi

Keyword(s):

Glycemic Control ◽

Lipid Profile ◽

Total Cholesterol ◽

Blood Sugar ◽

Significant Positive Correlation ◽

Poor Glycemic Control ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Background: Glycemic control, lipid control and other modifiable risk factor, is very important to prevent complications of type 2 diabetes. The objective of this study was to analyze glycemic control, lipid profile, BP and find the correlation of these parameters in the diabetic population of North Kerala.Methods: This was a cross sectional study among the type 2 diabetic patients with 40-60 years of age, and those without any cardiac, renal, liver, and thyroid dysfunction. Fasting blood sugar, BP, HbA1c and lipid profile were assessed by VITROS 5600 integrated system. The study population was grouped in to two based on their glycemic control (HbA1c ≥7% and HbA1c <7%). Statistical analysis was performed by SPSS software. The comparison of variables age, BP, FBS, HbA1c, total cholesterol, LDL, HDL, TG, and TG/HDL was tested using independent student t test. The correlations between the variables were analyzed using Pearson correlation coefficient. P values less than 0.05 were considered significant.Results: There was a significant positive correlation between DBP and poor glycemic control group (t=2.35, p=0.0102). Fasting blood sugar (p≤0.00001), total cholesterol (p=0.0031), triglycerides (p≤0.00001), LDL (p=0.0051), HDL (p=0.0010) and TG/HDL (p≤0.00001) also were significantly higher in this group. Age or gender showed no correlation with HbA1c and BP.Conclusions: This study shows highly significant positive correlation between TG/HDL and poor glycemic control. It appears the degree of hypertension is not correlated with HbA1c, but significantly correlated with lipid profile especially among those with poor glycemic control.

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