Evaluation of the macroscopic growth degree of experimental endometriosis in rats

PURPOSE: To evaluate macroscopically the growth degree of self-transplantation of endometriosis in rats. METHODS: Forty female rats, after a 7-day period for adpating and evaluating of the estrous cycle regularity, underwent tail abdominal midline laparotomy with 3-cm cuts. The average third of the left uterine horn was removed, 4mm x 4mm patches in liquid environment were made, and self-transplanted in the rat mesenterium with a single stitch, and the endometrial surface of the endometriotic implant facing the lumen of the peritoneal cavity. The rats were programmed to die after three weeks. The abdominal cavity displaying was held and self-transplants were identified and classified. RESULTS: The results achieved were: one case for degree 0 (2,5%), three cases for degree 1 (7,5%), eleven cases for degree II (27,5%) and twenty-five cases for degree III (62,5%). CONCLUSION: The experimental endometriosis development, through the self-transplantation technique, showed to be most common in degrees 3 and 2 of development.

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Shifts in preferred learning strategy across the estrous cycle in female rats

Hormones and Behavior ◽

10.1016/j.yhbeh.2004.01.005 ◽

2004 ◽

Vol 45 (5) ◽

pp. 330-338 ◽

Cited By ~ 146

Author(s):

Donna L Korol ◽

Emily L Malin ◽

Kristine A Borden ◽

Rachel A Busby ◽

Julia Couper-Leo

Keyword(s):

Estrous Cycle ◽

Learning Strategy ◽

Female Rats

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The anorectic effect of fenfluramine is influenced by sex and stage of the estrous cycle in rats

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00779.2004 ◽

2005 ◽

Vol 288 (6) ◽

pp. R1486-R1491 ◽

Cited By ~ 24

Author(s):

Lisa A. Eckel ◽

Heidi M. Rivera ◽

Deann P. D. Atchley

Keyword(s):

Food Intake ◽

Estrous Cycle ◽

Female Rats ◽

Male Rats ◽

Gonadal Hormone ◽

Estrous Female ◽

Male And Female Rats ◽

Daily Food ◽

Hormone Status ◽

Anorectic Effect

The controls of food intake differ in male and female rats. Daily food intake is typically greater in male rats, relative to female rats, and a decrease in food intake, coincident with the estrous stage of the ovarian reproductive cycle, is well documented in female rats. This estrous-related decrease in food intake has been attributed to a transient increase in the female rat's sensitivity to satiety signals generated during feeding bouts. Here, we investigated whether sex or stage of the estrous cycle modulate the satiety signal generated by fenfluramine, a potent serotonin (5-HT) releasing agent. To examine this hypothesis, food intake was monitored in male, diestrous female, and estrous female rats after intraperitoneal injections of 0, 0.25, and 1.0 mg/kg d-fenfluramine. The lower dose of fenfluramine decreased food intake only in diestrous and estrous females, suggesting that the minimally effective anorectic dose of fenfluramine is lower in female rats, relative to male rats. Although the larger dose of fenfluramine decreased food intake in both sexes, the duration of anorexia was greater in diestrous and estrous female rats, relative to male rats. Moreover, the magnitude of the anorectic effect of the larger dose of fenfluramine was greatest in estrous rats, intermediate in diestrous rats, and least in male rats. Thus our findings indicate that the anorectic effect of fenfluramine is modulated by gonadal hormone status.

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063 — (ROD0183) Voltage oscillations induced by intrahippocampal pilocarpine in female rats during the estrous cycle

Epilepsy & Behavior ◽

10.1016/j.yebeh.2014.08.096 ◽

2014 ◽

Vol 38 ◽

pp. 208-209

Author(s):

M.C.A. Rodrigues ◽

A.R. Isaac ◽

B.L.S. Andrade-da-Costa

Keyword(s):

Estrous Cycle ◽

Female Rats

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Comparative study of inflammatory response and adhesions formation after fixation of different meshes for inguinal hernia repair in rabbits

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502005000500002 ◽

2005 ◽

Vol 20 (5) ◽

pp. 347-352 ◽

Cited By ~ 30

Author(s):

Alberto Goldenberg ◽

Jacques Matone ◽

Wagner Marcondes ◽

Fernando Augusto Mardiros Herbella ◽

José Francisco de Mattos Farah

Keyword(s):

Inflammatory Response ◽

Abdominal Wall ◽

Peritoneal Cavity ◽

Abdominal Cavity ◽

Mesh Fixation ◽

Rabbit Model ◽

Laparoscopic Approach ◽

Preperitoneal Space ◽

Similar Amount ◽

The Right

PURPOSE: Compare, in a rabbit model, the inflammatory response and adhesions formation following surgical fixation of polypropilene and Vypro mesh in the inguinal preperitoneal space. METHODS: Fourteen male New Zealand rabbits, weighing between 2.000 to 2.500 g were used. A midline incision was made and the peritoneal cavity was exposed. The 2,0X1,0 cm polypropylene mesh was fixed in the left flank and secured to the margins with 3-0 prolene in a separate pattern. In the right flank, a 2,0X1,0 cm Vypro II mesh was sewn in the same way. After the post surgical period, the animals were again anesthetized and underwent laparoscopic approach, in order to identify and evaluate adhesions degree. Both fixed prosthesis were excised bilaterally with the abdominal wall segment, including peritoneum, aponeurosis and muscle and sent to a pathologist RESULTS: Operative time ranged from 15 to 25 minutes and no difficulties in applying the mesh were found. From the 14 polypropylene meshes fixed to the intact peritoneum, 11 had adhesions to the abdominal cavity (78,6%). Concerning Vypro mesh, 12 animals developed adhesions from the 14 with mesh fixation (85,7%). Histological examination of tissues harvested revealed fibroblasts, collagen, macrophages and lymphocytes between the threads of the mesh. CONCLUSION: Polypropylene and Vypro mesh, when implanted in the peritoneal cavity of rabbits provoke similar amount of adhesions. Vypro mesh tissues had higher fibrosis resulting in better mesh incorporation to the abdominal wall.

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Incarcerated Femoral Hernia Repair with Ventralex™ Hernia Patch through Same Skin Incision and Suprainguinal Laparotomy

Case Reports in Surgery ◽

10.1155/2018/9719310 ◽

2018 ◽

Vol 2018 ◽

pp. 1-3

Author(s):

David Aranovich ◽

Veacheslav Zilbermints ◽

Oleg Kaminsky

Keyword(s):

Hernia Repair ◽

Femoral Hernia ◽

Bowel Resection ◽

Abdominal Cavity ◽

Skin Incision ◽

Operative Approach ◽

Easy Access ◽

Midline Laparotomy ◽

Femoral Ring

Purpose. To report our experience with incarcerated femoral hernia procedure, which allows laparotomy through same inguinal skin incision, inspection and resection of compromised bowel, and preperitoneal tension-free transabdominal repair with Ventralex™ Hernia Patch.Materials and Methods. The suprainguinal laparotomy was performed via same groin incision without compromising iliopubic tract. The femoral ring was sealed with Ventralex™ Hernia Patch pulled through the abdominal cavity and secured outside. Five consecutive patients diagnosed with incarcerated femoral hernias were operated. All of them required laparotomy, either for bowel resection (n=3) or for inspection of viability (n=2).Results. All patients tolerated the procedure well. There were no wound or mesh infections, incisional hernias, or recurrences during follow-up.Conclusions. Our easy-to-master operative approach to incarcerated femoral hernia allows easy access to abdominal cavity through same groin incision without compromising iliopubic tract or midline laparotomy. Reduction of incarcerated bowel and its inspection and resection can be safely performed. The femoral ring defect can be effectively obliterated with Ventralex™ Hernia Patch.

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Maintenance of Estrous Cycle in Female Rats with Anterior or Posterior Deafferentation of the Suprachiasmatic Nucleus

Neuroendocrinology ◽

10.1159/000124948 ◽

1988 ◽

Vol 47 (5) ◽

pp. 444-452 ◽

Cited By ~ 2

Author(s):

Kouji Nomura ◽

Sumio Takahashi ◽

Seiichiro Kawashima

Keyword(s):

Estrous Cycle ◽

Suprachiasmatic Nucleus ◽

Female Rats

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Estrous cycle influence on individual differences in the response to novelty and cocaine in female rats

Behavioural Brain Research ◽

10.1016/j.bbr.2005.01.004 ◽

2005 ◽

Vol 161 (1) ◽

pp. 69-74 ◽

Cited By ~ 26

Author(s):

Stacy L. Sell ◽

Ashlee M. Dillon ◽

Kathryn A. Cunningham ◽

Mary L. Thomas

Keyword(s):

Individual Differences ◽

Estrous Cycle ◽

Female Rats

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Circadian and estrous cycle-dependent variations in blood pressure and heart rate in female rats

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1994.267.5.r1250 ◽

1994 ◽

Vol 267 (5) ◽

pp. R1250-R1256 ◽

Cited By ~ 8

Author(s):

H. Takezawa ◽

H. Hayashi ◽

H. Sano ◽

H. Saito ◽

S. Ebihara

Keyword(s):

Heart Rate ◽

Estrous Cycle ◽

Female Rats ◽

Constant Darkness ◽

Dark Phase ◽

Daily Rhythms ◽

Abrupt Decrease ◽

Internal Phase ◽

Free Running ◽

Cycle Dependent

To determine whether cardiovascular functions are controlled by the endogenous circadian system and whether they change with the estrous cycle in female rats, we measured mean arterial pressure (MAP), heart rate (HR), and spontaneous activity (ACT) of female rats using an implantable radiotelemetry device and a computerized data-collecting system. Under a 12:12-h light-dark (LD) cycle, these parameters exhibited daily rhythms that were entrained to the photic cycle. The patterns of the daily rhythms varied with estrous cycles, and variations were particularly marked in the proestrous stage. During the dark period of this stage, ACT levels were significantly higher, but HR was significantly lower than in other stages. Although the peak MAP occurred within 2 h after the onset of the dark phase in three of the estrous stages, it occurred around midnight in the proestrous stage. Such estrous cycle-dependent variations were eliminated by ovariectomy. The implantation of 17 beta-estradiol produced a gradual increase in MAP and an abrupt decrease in HR. During constant darkness, all three parameters were free running, maintaining the same internal phase relationships with each other as during LD cycles. These results indicate that daily variations in these parameters were controlled by the endogenous circadian oscillating system, that they vary with the estrous cycle in female rats, and that estrogen may be responsible for these estrous cycle-dependent variations.

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Kinetics of the cercaria-schistosomul um transformation in vivo: 2. The effect of oxamniquine

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86821985000400008 ◽

1985 ◽

Vol 18 (4) ◽

pp. 251-255 ◽

Cited By ~ 6

Author(s):

A. L. Melo ◽

L.H. Pereira

Keyword(s):

Peritoneal Cavity ◽

Abdominal Cavity ◽

Long Time ◽

Peritoneal Washings ◽

High Doses ◽

Kinetics Of

To study the cercaria-schistosomulum transformation in vivo, underthe influence of an antischistosomal compound (oxamniquine), a model using cercarial infections into the abdominal cavity of mice was chosen. This procedure provided easy and reproducible recoveries of larvae from peritoneal washings with appropriate solutions for a long time (30 to 180 min) after inoculation. The results show that high doses of oxamniquine (given intramuscularly one hour before the infection) produce a marked delay in the kinetics of the cercaria-schistosomulum transformation. Cercariae, tail-less cercarial bodies and schistosomula were recovered from the peritoneal cavity ofdrug treated mice in numbers significantly different from those recovered from untreated mice.

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