scholarly journals A proposal of multiplace hyperbaric chamber for animal experimentation and veterinary use

2008 ◽  
Vol 23 (4) ◽  
pp. 384-390 ◽  
Author(s):  
Fabrício Valandro Rech ◽  
Djalma José Fagundes ◽  
Reginaldo Hermanson ◽  
Henri Chaplin Rivoire ◽  
Anna Luiza Negrini Fagundes
Keyword(s):  
Animal Experimentation ◽  
Internal Space ◽  
Internal Diameter ◽  
Human Beings ◽  
Hyperbaric Chamber ◽  
Working Pressure ◽  
Master Cylinder ◽  
A36 Steel ◽  
Technical Specifications ◽  
Human Use

PURPOSE: To develop a project of hyperbaric chamber that allows its safe and reliable use in veterinary and animal experimentation. METHODS: Based on the technical specifications for the construction of hyperbaric chambers for human beings, it has been developed a design of a chamber with dimensions and characteristics for the use of a midsize animal, (dog or pig), as well as a multiple chamber for the use in small animals (mice, rats, hamsters, rabbits or cats). The technical specifications allowed that the chamber could be used both for veterinary use and for use in experiments on Health Sciences. RESULTS: A chamber with the following characteristics was built: ASTM A36 steel for the manufacture of the master cylinder and rear cover; front door built in 5052 aluminum; internal diameter of 50.5 cm and 83.0 cm in length; weight 160Kg and internal area of 150cm³; internal space to accommodate 2 acrylic baskets; 150mm high, 280mm wide and 690mm in length. It was capable of supporting a maximum of hydrostatic pressure test of 3.0 to 4.0 BAR ACT and maximum working pressure of 2.0 BAR or 3.0 ACT; equipped with security devices and valves that triggers with load of 2.2 BAR or 3.2 ACT. Tests for engineering and biological use on animals showed the effectiveness of the device. CONCLUSION: The development of the project enabled the construction of a hyperbaric chamber with security features and reliability comparable to those required by the legal and technical specifications of a hyperbaric chamber human use.

The Hebridean Blackhouse on the Isle of Barra

2000 ◽  
Vol 22 (1) ◽  
pp. 1-16 ◽  
Author(s):  
KEITH BRANIGAN ◽  
COLIN MERRONY
Keyword(s):  
Nineteenth Century ◽  
Internal Space ◽  
Use Of Space ◽  
Large Families ◽  
Human Use

The Hebridean blackhouse is a well-known part of the eighteenth and nineteenth century landscape of the Western Isles, described by numerous early travellers and preserved for posterity at Arnol in Lewis. Survey and excavation of blackhouses on the Isle of Barra, however, suggests that here at least, the majority of blackhouses did not conform to the 'norm' of a long building with accommodation shared by animals and humans. Despite the large families of the Catholic population of Barra, the houses are shorter and provide less internal space than blackhouses further north in the island chain. Animals were more often housed in separate byres. Similarly, the human use of space in the Barra blackhouses shows some variations from the pattern described by nineteenth century sources. As to the origins of the blackhouse, unexcavated sites on Barra suggest two possible future routes of enquiry.

scholarly journals Clinical Drug Trials on Human Beings viz-a-viz Sanctions related to Animal Experimentation: Need to do Introspection?

2012 ◽  
Vol 46 (3) ◽  
pp. 113-116
Author(s):  
Roosy Aulakh ◽  
Chander Shekhar Gautam ◽  
Prabhjot Singh Cheema
Keyword(s):  
Animal Experimentation ◽  
New Drugs ◽  
Drug Trials ◽  
Human Beings ◽  
Animal Protection ◽  
Research Organizations ◽  
Legal Sanctions ◽  
Clinical Drug Trials ◽  
Health Care Law ◽  
Clinical Drug

ABSTRACT Health care law is totally localized in its nature, but research for the development of new drugs has crossed man-made geographical limits. Weaker legal sanctions, poverty, illiteracy and inaccessibility to legal system have all contributed to make India a favored hub for contact research organizations. Many recent clinical drug trials in India have sparked controversy. However, in India today, we are more bothered about animal protection, but show little concern for volunteers in human trials. It is gradually becoming difficult to conduct research on animals; however, research on human beings is far easier. Sanctions against violation of rights of human volunteers in clinical trials are often only a perceived phenomenon. They are not protected as they should be. Regulatory framework needs thorough introspection, debate, reconsideration and strict implementation. These guidelines should not only be recommendatory but mandatory in nature and those who indulge in violations, shall be punished as per the law of the land effectively. How to cite this article Gautam CS, Aulakh R, Cheema PS. Clinical Drug Trials on Human Beings viz-a-viz Sanctions related to Animal Experimentation: Need to do Introspection? J Postgrad Med Edu Res 2012;46(3):113-116.

scholarly journals State of the art olfactometers. Different types

2021 ◽  
Keyword(s):  
Human Beings ◽  
Pathological Conditions ◽  
New Concepts ◽  
Different Types ◽  
Clinical Diagnoses ◽  
Human Use ◽  
The Brain ◽  
Very High ◽  
Human Olfaction

The complexity of human olfaction is very high and the importance of being able to measure it directly, objectively and qualitatively has led experts to search for mechanisms that can be applied. Human beings use this sense, which is one of the oldest, to recognize danger and distinguish between pleasant and unpleasant odors. Smells are mixtures of molecules that, at different concentrations in the inhaled air, stimulate the olfactory area and are recognized at the brain level. Therefore, there is a coding and decoding system. Human olfactometer techniques use equipment designed to be able to measure its intensity and quality of volatile substances. If we are able to measure this sense, we will be able to know its variations and be able to make clinical diagnoses in normal and pathological conditions and diagnose the losses that occur in certain infectious, degenerative diseases, traumatic processes and other variants. For many years, systems have been developed that can measure subjective olfaction in humans, as well as objective forms, but it is also true that there is no equipment available that is fast, simple handling and that can be applied in daily clinical services. Aim of the Study Present the recent achievements in olfactometer technology; Elaborate the scientific articles about olfactometry published mainly in the last 10 years; To gather the information published in the last years in relation to the usefulness, existence in the market and purposes of equipment that can measure the odors, what we will call the Smell-o-meter or olfactometer for human use. Material and Methods: In the first part of this research we will gather most of the information existing so far in international bibliography, as well as the achievements and utilities obtained to date. Following, we will analyze all the new concepts related to smell-o-meters devices that exist on the market and assess the possibility, based on what has been done so far, to seek new practical systems for application in the medical field.

scholarly journals Human non-decalcified histology of three dental implants 45 months under function—a case report

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Rafael Silveira Faeda ◽  
Suzana Clesia Silverio do Nascimento ◽  
Pâmela Leticia Santos ◽  
Rodolfo Jorge Boeck ◽  
Rafael Sartori ◽  
...  
Keyword(s):  
Case Report ◽  
Bone Tissue ◽  
Rare Event ◽  
Polarized Light ◽  
Collagen Fibers ◽  
Titanium Implants ◽  
Tissue Response ◽  
Internal Diameter ◽  
Human Beings ◽  
Circularly Polarized Light

Abstract Background Fracture of an implant is a quite rare event but represents an important opportunity to evaluate the peri-implant bone tissue response to implant overload in human beings. This study aimed to evaluate bone tissue around three fractured titanium implants retrieved from a human maxilla, by histomorphometric and birefringence analyses. Case report For this, the implants and the surrounding bone were removed after having been united to a tooth in function for 45 months, by a 4-mm internal diameter trephine bur, following an undecalcified section was obtained. The results showed a rate of 77.3% of bone-to-implant contact (BIC) and 80.3% of bone area filling within the limits of the implant threads. Under circularly polarized light microscopy investigation, the amount of the transverse collagen fibers was of 48.11%, and the amount of the longitudinal collagen fibers was of 51.89%. Conclusion Within the limitation of this study, the possible cause of the implant fracture could be the association of overload, inadequate implant diameter, and fragile internal hexagon connection.

Mountain History in Africa from the Earliest Times

2020 ◽  
Author(s):  
Christopher Conte
Keyword(s):  
Environmental History ◽  
Crystalline Rock ◽  
Human Beings ◽  
Geological Time ◽  
Water Ice ◽  
Mountain Landscape ◽  
History Of ◽  
Recent Phase ◽  
Human Use ◽  
Tectonic Forces

Over the long haul of geological time, the natural history of Africa’s mountains is a story of the lithosphere’s rise and fall. For hundreds of millions of years, tectonic forces have heaved up layers of metamorphic and igneous material while wind, water, ice, and gravity combined to open basins, scour valleys, and obliterate rock. The most recent phase in mountain building in Africa began in the Miocene (twenty-three million years ago) and continues today. Some mountains, like the volcanic mountains Kilimanjaro and Cameroon, are only a few million years old. Other highlands, like Tanzania’s Eastern Arc Mountains, derive from crystalline rock formed more than thirty million years ago. As they appear on the landscape today, Africa’s mountains present a mix of old and new landforms covered by a biosphere of resident plants and animals that evolved in the countless niches provided by elevation, slope, temperature, rainfall, and aspect. Human beings, relative latecomers to mountain history, have altered the highlands dramatically. In Africa, mountains attract people. Africa’s mountains do not constitute a discrete subject of study in the discipline of environmental history, though important studies of individual mountain zones do exist. Nor is the historical scholarship limited to the humanities. In studies that are essentially historical in approach, the natural sciences use empirical evidence to reconstruct mountain landscape change under human use. What follows is an attempt to knit together coherently a messy, multi-disciplinary scholarly literature.

Book Review: Norbert Wiener's The Human Use of Human Beings

1954 ◽  
Vol 31 (3) ◽  
pp. 369-370
Author(s):  
Charles H. Brown
Keyword(s):  
Human Beings ◽  
Human Use

Lathyrogenic Agents as Therapy for Subglottic Stenosis—A Pilot Study

1987 ◽  
Vol 97 (5) ◽  
pp. 446-451 ◽  
Author(s):  
Gary L. Livingston ◽  
Joyce A. Schild
Keyword(s):  
Pilot Study ◽  
Surgical Repair ◽  
Canine Model ◽  
Subglottic Stenosis ◽  
Laryngotracheal Stenosis ◽  
Human Beings ◽  
Scar Contracture ◽  
The Past ◽  
Human Use ◽  
Collagen Cross Linking

The surgical repair of subglottic stenosis (SGS) is often unsuccessful because of recurrence of the scar contracture. Over the past few years, two lathyrogenic agents (compounds that inhibit collagen cross-linking) have been shown effective in prevention of stenosis in animal models that have deep caustic esophageal burns. Since the principles of induced lathyrism have not been applied to the treatment of laryngotracheal stenosis, a pilot study using a canine model was conducted to test the efficacy of penicillamine and N-acetyl-L-cysteine in reduction of the rate of reformation of SGS. In all six animals used, a complete, 10 to 15 mm thick, mature SGS was induced experimentally, then opened with a Co2 laser. The dogs that were treated with lathyrogenic agents exhibited a lower rate of re-stenosis (one maintained patency throughout the 5 weeks of treatment) when compared to the two control dogs. Histologic sections of the subglottis in each dog revealed severe cricoid collapse, necrosis, and scarring, and thus demonstrated similarities to SGS in human beings. The two lathyrogenic agents used in this study are already approved for human use and may represent a valuable form of adjunctive therapy in the surgical management of SGS.

Book Review: The Human Use of Human Beings

1951 ◽  
Vol 28 (1) ◽  
pp. 110-111
Author(s):  
Bryant Kearl
Keyword(s):  
Human Beings ◽  
Human Use
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