scholarly journals 2-hydroxyethyl methacrylate composite - polypropylene mesh for preventing peritoneal adhesions in female dogs

2010 ◽  
Vol 25 (4) ◽  
pp. 342-346 ◽  
Author(s):  
Marcelo Seixo de Brito e Silva ◽  
Renato Miranda de Melo ◽  
Liliana Borges de Menezes ◽  
Sonia Maria Malmonge ◽  
Leandro Guimarães Franco ◽  
...  
Keyword(s):  
Polypropylene Mesh ◽  
Abdominal Muscle ◽  
The Other ◽  
Hydroxyethyl Methacrylate ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesions

PURPOSE: To evaluate whether the lining facing the visceral side of polypropylene mesh made with 2-hydroxyethyl methacrylate (p(HEMA)) hydrogel could avoid peritoneal adhesion in female dogs. METHODS: Eight animals (group PP) had a polypropylene mesh implanted to correct a defect in the rectal abdominal muscle, whereas in the other group (group PH) the polypropylene mesh was coated with p(HEMA) composite on the surface facing the peritoneal area. RESULTS: Adhesions were observed on the mesh in 62.5% of the PP group. In the PH group adhesions were present only on the suture lines. CONCLUSION: p(HEMA) hydrogel was well tolerated and effective in avoiding visceral and omental adhesions on the surface of the polypropylene mesh.

scholarly journals Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall

2010 ◽  
Vol 25 (4) ◽  
pp. 337-341 ◽  
Author(s):  
Neusa Margarida Paulo ◽  
Sonia Maria Malmonge ◽  
Liliana Borges de Menezes ◽  
Flávia Gontijo de Lima ◽  
Aline de Moraes Faria ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Histopathological Examination ◽  
Adhesion Formation ◽  
Foreign Body Response ◽  
Tissue Response ◽  
Female Rats ◽  
Hydroxyethyl Methacrylate ◽  
Peritoneal Adhesions ◽  
Body Response

PURPOSE: To verify if the composit poli (2-hydroxyethyl methacrylate)-PolyHEMA/polypropylene mesh implanted in the female rat's abdominal wall could be suitable for the prevention of peritoneal adhesions, and for the evaluation of the tecidual response produced by this biomaterial. METHODS: Polypropylene meshes (Group PP, n=20) and polypropylene meshes coated with a layer of poli (2-hydroxyethyl methacrylate)-PolyHEMA (Group PH, n=20) were implanted on the abdominal wall of Wistar female rats. Ten animals from each group were submitted to euthanasia at 15 and 30 days of the postoperative period. RESULTS: The animals from the group PP presented visceral adhesions on the mesh surface, which was not observed in the ones from group PH. At the histopathological examination foreign body response was observed in both groups, whilst there was a greater intensity of inflammatory response in group PH on both moments. CONCLUSION: The poli (2-hydroxyethyl methacrylate) polyHEMA hydrogel associated to polypropylene mesh reduces visceral adhesion formation in rats, although it may be associated to greater inflammatory reaction.

scholarly journals Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions

2006 ◽  
Vol 2006 ◽  
pp. 1-4 ◽  
Author(s):  
Clara Di Filippo ◽  
Alessandro Falsetto ◽  
Vito De Pascale ◽  
Elisabetta Tufariello ◽  
Domenico De Lucia ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Adhesion Formation ◽  
Plasminogen Activator Inhibitor ◽  
Lavage Fluid ◽  
Plasminogen Activator Inhibitor 1 ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesions ◽  
Risk Patients ◽  
Activator Inhibitor ◽  
Pai 1

This study has evaluated whether systemic changes of plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) parallel the adhesions development and whether they could be used as predictors of adhesion risk. This has been studied in an animal model of post-surgical peritoneal adhesion by monitoring for 10 days the plasma and tissue levels of t-PA and PAI-1. The results showed that both tissular and plasmatic levels of t-PA were decreased in concomitance with the development of peritoneal adhesions. In contrast, PAI-1 was found increased into the tissue and into the plasma samples of the rats taken at 5 and 10 days time points. Inflammatory mediators such as ICAM-1, VCAM-1, and IL-6 within the peritoneal lavage fluid also correlated with the adhesion formation process. In conclusion, post-surgical peritoneal adhesions provide alterations of local inflammatory components and local and systemic fibrinolytic components, possibly with PAI-1 quenching t-PA. This may have potential for the identification of high-risk patients.

Use of chitosan membrane associated with polypropylene mesh to prevent peritoneal adhesion in rats

2009 ◽  
Vol 91B (1) ◽  
pp. 221-227 ◽  
Author(s):  
Neusa Margarida Paulo ◽  
Marcelo Seixo de Brito e Silva ◽  
Ângela Maria Moraes ◽  
Ana Paula Rodrigues ◽  
Liliana Borges de Menezes ◽  
...  
Keyword(s):  
Polypropylene Mesh ◽  
Peritoneal Adhesion ◽  
Chitosan Membrane

scholarly journals Comparative study of hand sewn single layer anastomosis of dog's bowel

2008 ◽  
Vol 45 (4) ◽  
pp. 319-322 ◽  
Author(s):  
João Luiz Moreira Coutinho Azevedo ◽  
Octávio Hypólito ◽  
Otávio Cansanção Azevedo ◽  
Otávio Monteiro Becker Jr. ◽  
Dalmer Faria Freire
Keyword(s):  
Digestive Tract ◽  
Acute Inflammation ◽  
Statistical Significance ◽  
Intestinal Anastomosis ◽  
Single Layer ◽  
The Other ◽  
Surgical Anastomosis ◽  
Peritoneal Adhesions ◽  
Friedman's Test ◽  
Microscopic Features

BACKGROUND: Two-layer intestinal anastomosis increases the inflammatory response while single-layer anastomosis results in a better wound healing. However the four main kinds of stitches which may be chosen in performing single layer intestinal sutures never before had been comparatively studied. AIM: To compare the four more commonly used types of single layer surgical anastomosis sutures of the digestive tract. METHODS: Six mongrel dogs were operated, each one receiving two anastomosis: one at 30 cm from de Treitz angle - sero-submucosal technique, and the other at 60 cm - total technique. This placement was alternatively inverted. The four more commonly used types of single layer surgical anastomosis sutures of the digestive tract, namely: sero-submucosal stitches tied in the lumen, over the submucosa; sero-submucosal stitches tied in the exterior of the organ, over the serosa; total stitches tied in the lumen, over the mucosa; and total sutures tied in the exterior, over the serosa (Gambee's stitches) were tested. After euthanasia (7th post-operative day) macro and microscopic features were evaluated. Friedman's test was applied for morphometry and for evaluation of the peritoneal adhesions. RESULTS: Statistical significance was demonstrated through major residual acute inflammation and proliferation in total sutures and more profuse adhesions with the sero-submucosal stitches tied in the lumen. The sero-submucosal stitches tied in the exterior over the serosa, had excellent realignment and regeneration of the layers. CONCLUSION: The sero-submucosal stitches tied in the exterior, over the serosa, were the best ones.

Reduction of Peritoneal Adhesion to Polypropylene Mesh with the Application of Fibrin Glue

2008 ◽  
Vol 108 (4) ◽  
pp. 433-437 ◽  
Author(s):  
E. Prieto-Díaz-Chávez ◽  
J. Luis Medina-Chávez ◽  
E.J. Ramírez-Barba ◽  
B. Trujillo-Hernández ◽  
R.O. Millán-Guerrero ◽  
...  
Keyword(s):  
Fibrin Glue ◽  
Polypropylene Mesh ◽  
Peritoneal Adhesion

scholarly journals Polylactic acid film versus acellular porcine small intestinal submucosa mesh in peritoneal adhesion formation in rats

2009 ◽  
Vol 24 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Ricardo Gonçalves da Costa ◽  
Marcelo Betancort Lontra ◽  
Priscila Scalco ◽  
Leandro Totti Cavazzola ◽  
Richard Ricachenewski Gurski
Keyword(s):  
Polypropylene Mesh ◽  
Rupture Strength ◽  
Adhesion Formation ◽  
Albino Rats ◽  
Peritoneal Adhesions ◽  
Barrier Methods ◽  
Group 3 ◽  
Group 2 ◽  
Intestinal Submucosa ◽  
Group 1

PURPOSE: To assess intraperitoneal adhesion formation in rats after the single implantation of intraperitoneal polypropylene mesh versus SIS mesh, and the effect of PAF as a polypropylene mesh barrier. METHODS: A total of 55 albino rats randomized into three groups were assessed. The type of adhesions, the percentage of mash covered with adhesions, and the rupture strength of the adhesions were evaluated. RESULTS: The type 2 and 3 adhesions were more frequent in group 1 (polypropylene mesh) and group 3 (Polypropylene+PAF), while type 0 and 1 adhesions were more frequent in group 2 (SIS). The mean rupture strength was 1,58 N (±0,719N) in group 1, 0,42 N (±0,432N) in group 2 and 1,23 N (±0,432N) in group 3. Over 50% of the mash was covered with adhesions in 12 (80%) cases of the group 1, in 4 (20%) cases of the group 2 and in 16 (84,2%) cases of the group 3. Group 2 differed significantly (p<0.001) from the other groups. CONCLUSIONS: Implantation of intraperitoneal polypropylene mesh yielded higher rates of adhesion and the use of PAF as a mesh barrier didn't reduced the rates of adhesion. SIS mesh implantation revealed lower rates of peritoneal adhesions.

Reflex control of abdominal muscles during positive-pressure breathing

1964 ◽  
Vol 19 (2) ◽  
pp. 224-232 ◽  
Author(s):  
Beverly Bishop
Keyword(s):  
Abdominal Muscle ◽  
Spinal Reflexes ◽  
The Other ◽  
Positive Pressure ◽  
Abdominal Muscles ◽  
Afferent Pathways ◽  
Muscle Response ◽  
Thoracic Spinal ◽  
Vagal Afferent ◽  
Continuous Positive Pressure

Continuous positive-pressure breathing initiates expiratory activity in the abdominal muscle and inhibits the diaphragm in anesthetized cats. This investigation defines neural mechanisms involved in this abdominal muscle response (AMR) to positive-pressure breathing. The AMR is not a segmental reflex since it is abolished by thoracic spinal transection. Bilateral rhizotomy (T8-L3) also eliminates AMR, but laparotomy and abdominal evisceration do not, suggesting that some neural inflow other than from abdominal muscle or viscera is necessary but insufficient for maintaining AMR. Abdominal vagotomy failed to interrupt AMR which was abolished by bilateral cervical vagotomy, indicating that the necessary receptors lie in the thorax. Compression or local anesthesia of the cervical vagi provided the experimental means for abolishing either the inhibition of the diaphragm or the AMR without necessarily interrupting the other. That one response may persist in the absence of the other indicates that vagal afferent pathways subserving AMR are distinct from those mediating diaphragm inhibition. Hence the active expiration of pressure breathing is not a simple corollary of the Hering-Breuer inflation reflex but is a separate reflex served by its own vagal pathway. abdominal muscle response; vagus control of active expiration; abdominal muscle motoneuron pool; vagal afferent pathway in pressure-breathing reflex; thoracic receptors; diaphragm response to pressure breathing; diaphragm; inspiration; expiratory reflexes; inspiratory reflexes; respiratory reflexes; segmental reflexes; spinal reflexes Submitted on February 21, 1963

Effect of phosphatidylcholine on the process of peritoneal adhesion following implantation of a polypropylene mesh prosthesis

Biomaterials ◽  
1996 ◽  
Vol 17 (14) ◽  
pp. 1369-1372 ◽  
Author(s):  
J.M. Bellón ◽  
L.A. Contreras ◽  
J. Buján ◽  
F. Jurado
Keyword(s):  
Polypropylene Mesh ◽  
Peritoneal Adhesion ◽  
Mesh Prosthesis

scholarly journals Validation of peritoneal adhesion index as a standardized classification to universalize peritoneal adhesions definition

2017 ◽  
Author(s):  
Paola Fugazzola ◽  
Federico Coccolini ◽  
Gabriela E. Nita ◽  
Giulia Montori ◽  
Davide Corbella ◽  
...  
Keyword(s):  
Bowel Obstruction ◽  
Roc Curve ◽  
Surgical Intervention ◽  
Multicenter Trial ◽  
Previous Surgery ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesions ◽  
Surgical Interventions ◽  
Definition Of ◽  
Adhesion Index

Peritoneal adhesion index (PAI) is a score based on appearance and distribution of peritoneal adhesions. The study aims to assess the validity of PAI in order to standardize the definition of peritoneal adhesions. The study includes an expert survey to assess the feasibility of the score and a prospective observational and multicenter trial to assess its validity. 96% of surgeons of the survey consider PAI a useful tool. From January 2013 to March 2015, 205 patients were enrolled to undergo a surgical intervention for bowel obstruction caused by peritoneal adhesions in 21 centers. PAI was significantly higher in the population with previous surgery (P=0.043) and in patients who underwent two previous surgical interventions, if compared to those with only one previous intervention (P=0.012). Length of surgery was significantly longer in patients with higher PAI (P<0.001). Patients with a higher PAI showed a clinically higher risk for early bowel re-obstruction and for early re-intervention. The AUC of the ROC curve for early re-occlusion is 0.8. PAI can be considered a feasible and useful score.

scholarly journals Comparison between polypropylene and polypropylene with poliglecaprone meshes on intraperitoneal adhesion formation

2016 ◽  
Vol 43 (6) ◽  
pp. 416-423 ◽  
Author(s):  
MARIA DE LOURDES PESSOLE BIONDO-SIMÕES ◽  
WAGNER AUGUSTO SCHIEL ◽  
MAYARA ARANTES ◽  
TATIANE DA SILVEIRA ◽  
ROGÉRIO RIBEIRO ROBES ◽  
...  
Keyword(s):  
Polypropylene Mesh ◽  
Wistar Rats ◽  
Adhesion Formation ◽  
The Other ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Male Wistar Rats ◽  
Group 2 ◽  
Level Of Significance ◽  
Group 1

ABSTRACT Objective: to compare intraperitoneal adhesion formation in rats when using polypropylene and polypropylene with poliglecaprone meshes. Methods: we used twenty male, Wistar rats, divided in two groups. In group 1, the rats received the polypropylene mesh on their right side and the polypropylene with poliglecaprone mesh on their left side. In group 2 the position of the meshes was inverted. After 30 days, we analyzed the presence or not of adhesion formation, including only those over the meshes. The findings undergone an analysis through the Mann-Whitney test, at a level of significance of p≤0.05. Results: all meshes presented adhesions. We verified that, for the polypropylene meshes, the percentage of their surface covered by adhesions varied from 10.5 to 100%, with an average of 34.07±24.21%, while for the polypropylene with poliglecaprone mesh, the percentage covered by adhesions varied between 8.5% and 100%, with an average of 44.7±32.85% (p=0.12). Conclusion: both meshes lead to adhesion formation, none being superior to the other.

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