scholarly journals Neurological examination in obsessive-compulsive disorder

1996 ◽  
Vol 114 (5) ◽  
pp. 1255-1258 ◽  
Author(s):  
Paulo Caramelli ◽  
Mauro Aranha de Lima ◽  
Emmanuel Stip ◽  
Luiz Alberto Bacheschi
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Neurological Examination ◽  
Neurological Dysfunction ◽  
Clinical Value ◽  
Obsessive Compulsive ◽  
Neurological Soft Signs ◽  
Compulsive Disorder ◽  
Mirror Movements ◽  
Neurological Evaluation ◽  
Preliminary Stress

Recent studies suggest the occurrence of a neurological dysfunction in Obsessive-Compulsive Disorder (OCD). The purpose of the present study was to verify the clinical value of a neurological evaluation in patients with the disease. We submitted 15 patients with OCD (five of whom were under clomipramine) and 15 controls in a detailed neurological examination, including assessment of the neurological soft-signs. Eleven patients (73.3 percent) and four controls (26.7 percent) presented abnormalities on examination. The main findings among the patients were: palmomental reflex (six cases); mirror movements (five cases); agraphestesia and dysdiadochokinesia (three cases). Three out of the four patients who had a normal examination were on clomipramine. Palmomental reflex was the main finding among the controls. These results, although preliminary, stress the interest and usefulness of performing a detailed neurological examination in OCD.

Psychophysiological and clinical value of event-related potentials in obsessive-compulsive disorder

1997 ◽  
Vol 42 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Pierre M. Morault ◽  
Marc Bourgeois ◽  
Jérôme Laville ◽  
Claude Bensch ◽  
Jacques Paty
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Event Related Potentials ◽  
Clinical Value ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Related Potentials

scholarly journals Neurological soft signs in obsessive-compulsive disorder: two empirical studies and meta-analysis

2012 ◽  
Vol 43 (5) ◽  
pp. 1069-1079 ◽  
Author(s):  
N. Jaafari ◽  
L. Fernández de la Cruz ◽  
M. Grau ◽  
E. Knowles ◽  
J. Radua ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Motor Coordination ◽  
Meta Analysis ◽  
Empirical Studies ◽  
The Body ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Neurological Soft Signs ◽  
Definitive Answer ◽  
Compulsive Disorder

BackgroundNeurological soft signs (NSS) have been inconsistently reported in obsessive-compulsive disorder (OCD) but may make an impact on treatment response.MethodThe current study examined the presence of NSS in two independent European samples of OCD patients (combined 85 patients and 88 matched healthy controls) using a standardized instrument and conducted a meta-analysis of all published studies identified in the literature with the aim to provide a more definitive answer to the question of whether OCD patients are characterized by increased NSS.ResultsBoth empirical studies found elevated NSS scores in patients compared with matched controls. The results of the meta-analysis, which included 15 studies (combined 498 patients and 520 controls) showed large effect sizes (Hedges' g=1.27, 95% confidence interval 0.80–1.75), indicating that OCD patients have significantly higher rates of NSS than matched controls on both sides of the body and in multiple domains (motor coordination, sensory integration and primitive reflexes). The results were robust and remained largely unchanged in our reliability analyses, which controlled for possible outliers. Meta-regression was employed to examine the role of potential variables of interest including sociodemographic variables, symptom severity, medication effects and the use of different instruments, but none of these variables was clearly associated with NSS.ConclusionsAs a group, OCD patients are characterized by increased rates of NSS, compared with healthy controls. However, their origins and potential clinical importance remain to be clarified. Future directions for research are discussed.

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