scholarly journals Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder

2009 ◽  
Vol 31 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Quirino Cordeiro ◽  
Carolina Cappi ◽  
Aline Santos Sampaio ◽  
Selma Aliotti Palácios ◽  
Carlos Alberto de Bragança Pereira ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Molecular Genetic ◽  
Immunological Response ◽  
Obsessive Compulsive ◽  
Brazilian Sample ◽  
Compulsive Disorder ◽  
Objective Evidence ◽  
Gene Enhancer ◽  
Negative Findings ◽  
And Gender

OBJECTIVE: Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder. METHOD: The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls. RESULTS: There were no differences in genotypic distributions between patients and controls (χ2 = 0.98; 2 d.f.; p = 0.61). DISCUSSION: Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied. CONCLUSION: The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample.

Combining Pharmacotherapy and Exposure Plus Ritual Prevention for Obsessive Compulsive Disorder: Research Findings and Clinical Applications

2005 ◽  
Vol 19 (4) ◽  
pp. 317-330 ◽  
Author(s):  
Martin E. Franklin ◽  
H. Blair Simpson
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Behavioral Therapy ◽  
Combined Treatment ◽  
Comorbid Depression ◽  
Obsessive Compulsive ◽  
Case Examples ◽  
Compulsive Disorder ◽  
Negative Findings ◽  
Research Findings ◽  
Made In

The efficacy of cognitive-behavioral therapy (CBT) involving exposure and ritual prevention (EX/RP) for obsessive compulsive disorder (OCD) has been well documented, as has the efficacy of pharmacotherapy using serotonin reuptake inhibitors (SRIs). Response to these monotherapies is neither universal nor complete, however, and in the past 20 years significant progress has been made in examining the efficacy of combined EX/RP plus SRI treatment. Results of randomized controlled trials that have employed adequate methodology suggest that combined treatment may afford some advantages over the monotherapies, although the effect is generally not robust and there are some negative findings. Combined treatment may be especially useful in certain clinical circumstances, however, and case examples are provided describing the use of combined treatment for one patient who presented with comorbid depression and for another who refused EX/RP because he perceived it as too threatening.

Brain 5-HT function in obsessive-compulsive disorder

1997 ◽  
Vol 171 (3) ◽  
pp. 280-282 ◽  
Author(s):  
N. A. Fineberg ◽  
A. Roberts ◽  
S. A. Montgomery ◽  
P. J. Cowen
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Age And Gender ◽  
Compulsive Disorder ◽  
Therapeutic Advantage ◽  
Neuroendocrine Function ◽  
Prolactin Response ◽  
And Gender ◽  
Drug Free

BackgroundDrugs that potentiate brain serotonin (5-HT) neurotransmission are effective in the treatment of obsessive–compulsive disorder (OCD), but it is unclear whether disturbances in brain 5-HT function play a role in the pathophysiology of OCD.MethodWe studied the prolactin response to the selective 5-HT releasing agent d-fenfluramine in 14 non-depressed, drug-free OCD patients, and 14 healthy controls matched for age and gender.ResultsThe prolactin response to d-fenfluramine was significantly increased in OCD patients compared with controls.ConclusionsThe disparate results of studies of 5-HT neuroendocrine function in OCD make it unlikely that disturbances of brain 5-HT function play a central role in the pathophysiology of OCD. Increased brain 5-HT neurotransmission in non-depressed OCD subjects may represent an adaptive neurobehavioural mechanism which can be amplified to therapeutic advantage by treatment with 5-HT potentiating drugs.

scholarly journals Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample

2007 ◽  
Vol 65 (4a) ◽  
pp. 936-941 ◽  
Author(s):  
Karen Miguita ◽  
Quirino Cordeiro ◽  
Jacqueline Siqueira-Roberto ◽  
Roseli Gedanke Shavitt ◽  
José Carlos Ramos Castillo ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Obsessive Compulsive Disorder ◽  
Age At Onset ◽  
Tic Disorders ◽  
Transporter Gene ◽  
Obsessive Compulsive ◽  
Dopamine Transporter Gene ◽  
Brazilian Sample ◽  
Compulsive Disorder ◽  
Co Morbidity

Family, twin and segregation analysis have provided evidences that genetic factors are implicated in the susceptibility for obsessive-compulsive disorder (OCD). Several lines of research suggest that the dopaminergic system may be involved in the pathophysiology of OCD. Thus, the aim of the present study was to investigate a possible association between a polymorphism located in intron 8 of the dopamine transporter gene (SLC6A3) and OCD in a Brazilian sample composed by 208 patients and 865 healthy controls. No statistically differences were observed in allelic and genotype distributions between cases and controls. No association was also observed when the sample was divided according to specific phenotypic features such as gender, presence of tic disorders co-morbidity and age at onset of obsessive-compulsive symptoms (OCS). Our results suggest that the intron 8 VNTR of the SLC6A3 investigated in this study is not related to the susceptibility for OCD in our Brazilian sample.

scholarly journals Moderators and predictors of response to cognitive-behavioral therapy augmentation of pharmacotherapy in obsessive–compulsive disorder

2010 ◽  
Vol 40 (12) ◽  
pp. 2013-2023 ◽  
Author(s):  
M. J. Maher ◽  
J. D. Huppert ◽  
H. Chen ◽  
N. Duan ◽  
E. B. Foa ◽  
...  
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Obsessive Compulsive Disorder ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Controlled Study ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Randomized Controlled ◽  
Treatment Type ◽  
And Gender

BackgroundCognitive-behavioral therapy (CBT) consisting of exposure and response prevention (EX/RP) is efficacious as a treatment for obsessive–compulsive disorder (OCD). However, about half of patients have a partial or poor response to EX/RP treatment. This study examined potential predictors and moderators of CBT augmentation of pharmacotherapy, to identify variables associated with a poorer response to OCD treatment.MethodData were drawn from a large randomized controlled trial that compared the augmenting effects of EX/RP to stress management training (SMT; an active CBT control) among 108 participants receiving a therapeutic dose of a serotonin reuptake inhibitor (SRI). Stepwise regression was used to determine the model specification.ResultsPretreatment OCD severity and gender were significant moderators of outcome: severity affected SMT (but not EX/RP) outcome; and gender affected EX/RP (but not SMT) outcome. Adjusting for treatment type and pretreatment severity, significant predictors included greater co-morbidity, number of past SRI trials, and lower quality of life (QoL). Significant moderators, including their main-effects, and predictors accounted for 37.2% of the total variance in outcome, comparable to the impact of treatment type alone (R2=30.5%). These findings were replicated in the subgroup analysis of EX/RP alone (R2=55.2%).ConclusionsThis is the first randomized controlled study to examine moderators and predictors of CBT augmentation of SRI pharmacotherapy. Although effect sizes for individual predictors tended to be small, their combined effect was comparable to that of treatment. Thus, future research should examine whether monitoring for a combination of these risk factors and targeting them with multi-modular strategies can improve EX/RP outcome.

scholarly journals Obsessive Compulsive Disorder and its Relationship with Some Variables

2017 ◽  
Vol 11 (2) ◽  
pp. 297
Author(s):  
Manal K. Al Fazari ◽  
Mohammad I. Safasfeh ◽  
Mahmoud M. Ibrahim
Keyword(s):  
Academic Achievement ◽  
University Students ◽  
Obsessive Compulsive Disorder ◽  
Face Validity ◽  
Cronbach’S Alpha ◽  
Obsessive Compulsive ◽  
Sultan Qaboos University ◽  
Compulsive Disorder ◽  
Cronbach's Alpha ◽  
And Gender

This study aims at reporting on the prevalence of Obsessive Compulsive Disorder (OCD) and its relation to some variables including gender, college, academic achievement and region among Sultan Qaboos university students. The Arabic adapted version of OCD Scale designed by Ibrahim and Al Fazari (2015) was administered to a sample of 820 students from all university colleges (2014-2015 academic year enrolments). The OCD validity was assessed using face validity, criterion-related validity, and factorial validity. The reliability of the OCD was assessed using Cronbach’s alpha and split-half method. The Cronbach’s alpha coefficient was .86 whereas the split- half method coefficient was .82. This study showed a higher level of obsessive compulsive disorder among university students (48. 53%). It was also found significant relationships between OCD and gender. A higher level of OCD was reported among female than male students. In addition, a significant relationship was found due to the college, academic achievement and region.

scholarly journals Case Report: Doubts and Pre-occupations About Being Transgender: Questioning One's Gender Identity or a Case of Obsessive-Compulsive Disorder?

2021 ◽  
Vol 12 ◽  
Author(s):  
Elias Aboujaoude ◽  
Vladan Starcevic
Keyword(s):  
Gender Identity ◽  
Obsessive Compulsive Disorder ◽  
Mental Health Professionals ◽  
Sex And Gender ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Biological Sex ◽  
Gender Minorities ◽  
Gender Based ◽  
And Gender

We report the case of a biological female with gender identity-related doubts that were misconstrued as suggesting obsessive-compulsive disorder (OCD). The patient's parent seemed to favor an OCD explanation for the gender-based self-questioning over acceptance of possible transgender identity. We discuss what OCD is and what it is not in the context of gender identity-based doubt; analogy with the better studied sexual orientation-related OCD; cultural flashpoints around sex and gender that can become the object of OCD; how confusion about biological sex, assigned gender and gender identity can lead to clinical harm; and the role of mental health professionals in fighting the stigma faced by gender minorities.

scholarly journals Obsessive Compulsive Disorder: Frequency and Gender Estimates

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Shaista Jabeen ◽  
Rukhsana Kausar
Keyword(s):  
Gender Difference ◽  
Mental Disorders ◽  
Obsessive Compulsive Disorder ◽  
Clinical Population ◽  
Obsessive Compulsive ◽  
Local Data ◽  
Community Based Research ◽  
Compulsive Disorder ◽  
Number Of Patients ◽  
And Gender

Objective: Frequency data on mental disorders is a crucial requirement for primary, secondary and tertiary prevention. However, such local data is sparse. The study aimed to estimate frequency and gender differences of Obsessive Compulsive Disorder (OCD) in clinical population. Method: Retrospective data of adult patients (18 years and above) reported in Out Patient Departments (OPD) of four teaching hospitals and a private clinic was collected. Successive three years record was consulted using OPD registers. Gender difference in frequency of OCD was estimated. Results: Altogether 90119 patients were registered in five psychiatric settings in major cities of Punjab during three year period. As information was missing for over one third of the registered patients, hence analysis was carried out on valid cases only i.e. 59220 (65.8% of the total number of patients registered). It was revealed that the estimated frequency of OCD is 4.1%. There was no significant gender difference revealed in frequency of OCD (P>0.05). Conclusion: Frequency of OCD implicate the need for early detection and intervention of the disorder. Further, it elucidates the importance of community based research on other mental disorders. The need for accurate record keeping which is a core element for any research related with medical or psychological issue is also highlighted. doi: https://doi.org/10.12669/pjms.36.5.1870 How to cite this:Jabeen S, Kausar R. Obsessive Compulsive Disorder: Frequency and Gender Estimates. Pak J Med Sci. 2020;36(5):---------.  doi: https://doi.org/10.12669/pjms.36.5.1870 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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