scholarly journals Interobserver agreement of gleason score and modified gleason score in needle biopsy and in surgical specimen of prostate cancer

2007 ◽  
Vol 33 (5) ◽  
pp. 639-651 ◽  
Author(s):  
Sergio G. Veloso ◽  
Mario F. Lima ◽  
Paulo G. Salles ◽  
Cynthia K. Berenstein ◽  
Joao D. Scalon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Interobserver Agreement ◽  
Surgical Specimen

scholarly journals Is there a correlation between the aggressiveness of chronic asymptomatic prostatitis NIH category IV and the Gleason score in patients with prostate cancer?

2019 ◽  
Vol 14 (11) ◽  
Author(s):  
Erdogan Aglamis ◽  
Cavit Ceylan ◽  
Mustafa Akin
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Newly Diagnosed ◽  
Prostate Needle Biopsy ◽  
Retrospective Design ◽  
Biopsy Specimens ◽  
Grade 3 ◽  
Prostatic Inflammation

Introduction: We evaluated the correlation between the International Society of Urological Pathology (ISUP) grades and the aggressiveness grades of prostate inflammation in newly diagnosed prostate cancer patients with chronic asymptomatic prostatitis National Institiutes of Health (NIH) category IV (CAPNIHIV). Methods: The study comprised 357 consecutive patients with prostate cancer in whom a cancer diagnosis had been made via a prostate needle biopsy. Histological sections of the prostate biopsy specimens of the patients were reviewed and scored. Prostatic inflammation was scored using the aggressiveness grade of inflammation. The associations between the ISUP grades and the aggressiveness grades of inflammation were analyzed using logistic regression. The limitations of the study were its retrospective design and the limited number of cases. Results: In 110 (31%) patients, CAPNIHIV was detected: 56 (51%) patients had a grade 0 aggressiveness score, 34 (31%) patients had a grade 1 aggressiveness score, and 20 (18%) patients had a grade 2 aggressiveness score. The patients who had prostatic inflammation had a 1.65 times (95% confidence interval [CI] 1.05–2.61) greater likelihood of a high ISUP grade (grade ≥3) compared with the patients who did not have prostatic inflammation. The association between the ISUP grade and the aggressiveness grade of inflammation was more pronounced for a grade 2 aggressiveness score (n= 20; odds ratio 2.97; 95% CI 1.14–7.71). Conclusions: In prostate cancer patients with CAPNIHIV, there was a positive correlation between the inflammation aggressiveness grade and the ISUP grade. The aggressiveness of intraprostatic inflammation may be an important morphological factor affecting the Gleason score.

Is systematic 10 core prostate needle biopsy enough for treatment determination of localized prostate cancer?

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 163-163
Author(s):  
Ryo Kishimoto ◽  
Ryuta Tanimoto ◽  
Kensuke Bekku ◽  
Yasuyuki Kobayashi ◽  
Shin Ebara ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Multivariate Analysis ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Chi Square ◽  
Prostate Needle Biopsy ◽  
Significant Difference ◽  
Chi Square Test

163 Background: To evaluate whether the systematic 10 cores prostate needle biopsy is enough for determination of NCCN risk classification (NRC), we analyzed migration of Gleason score (GS), cancer location, and NRC between pre and postoperative periods in a cohort of patients who underwent radical prostatectomy. Methods: A total of 197 patients were included in this study. These patients were divided into three groups along the number of biopsy cores: less than 10 (L), 10, and more than 10 (M). We compared between three groups about Gleason score, cancer location and NCCN risk classification change (CC) between prostate biopsy and radical prostatectomy specimen. Statistical analysis were performed with chi-square test, and multiple logistic regression with p<0.05, and Bonferroni correction with p<0.017 considered significant difference. Results: The rate of CC in L, 10, M was 55.1%, 43.0%, 26.5%, respectively. On chi-square test rates of CC were significantly different between three groups (P=0.035), but rates of Gleason score and cancer location were not. On univariate analysis, PSA (Odds rate (OR) 0.872 p<0.001), preoperative NRC (low vs. intermediate, and poor, OR 0.157 and 0.241, p<0.001), prostate volume (normal vs. mild or moderate, OR 1.989 p=0.025), the number of biopsy cores (L vs. M, OR 0.293 p=0.011), GS (6 vs. 8, OR 2.374 p=0.021) were correlated with CC. On multivariate analysis, the most important independent predictive factors for CC were preoperative NRC (low vs. intermediate, p<0.001, OR 0.198, 95% CI 0.09-0.45) and PSA (p=0.007, OR 0.903, 95%CI 0.83-0.98), but the number of biopsy cores was not associated CC significantly. Conclusions: Although multivariate analysis showed no significant difference, the more biopsy cores reduced the risk of CC. Systematic 10 core biopsy might be insufficient for accurate diagnosis and treatment decision of prostate cancer.

Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade

2010 ◽  
Vol 105 (5) ◽  
pp. 631-635 ◽  
Author(s):  
Deirdre M. Fanning ◽  
Elaine Kay ◽  
Yue Fan ◽  
John M. Fitzpatrick ◽  
R. William G. Watson
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Intermediate Grade ◽  
Biopsy Gleason Score ◽  
Cancer Grading

Cribriform morphology predicts upstaging after radical prostatectomy in patients with Gleason score 3 + 4 = 7 prostate cancer at transrectal ultrasound (TRUS)-guided needle biopsy

2015 ◽  
Vol 467 (4) ◽  
pp. 437-442 ◽  
Author(s):  
Daniel T. Keefe ◽  
Nicola Schieda ◽  
Soufiane El Hallani ◽  
Rodney H. Breau ◽  
Chris Morash ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Transrectal Ultrasound

Comparison of Classic and International Society of Urological Pathology 2005 Modified Gleason Grading Using Needle Biopsies From the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial

2013 ◽  
Vol 137 (12) ◽  
pp. 1740-1746 ◽  
Author(s):  
M. Scott Lucia ◽  
David G. Bostwick ◽  
Matthew C. Somerville ◽  
Ivy L. Fowler ◽  
Roger S. Rittmaster
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
International Society ◽  
Scoring System ◽  
Interobserver Agreement ◽  
Scoring Systems ◽  
High Grade ◽  
Gleason Grading ◽  
Modified Gleason Grading ◽  
Score Distributions

Context.—Use of the International Society of Urological Pathology (ISUP) 2005 modified Gleason score may result in higher scores compared with the classic Gleason scoring system. Objective.—To compare scores derived using the 2 scoring systems. Design.—On-study and for-cause biopsies were centrally reviewed and assigned a classic Gleason score in the Reduction by Dutasteride of prostate Cancer Events trial. Positive biopsies were reviewed by an independent pathologist in a secondary review using the ISUP 2005 modified Gleason score. The independent pathologist also recorded a classic Gleason score. Results.—In total, 1482/1507 (98%) positive biopsy results were independently reviewed. Scores assigned by the 2 pathologists (classic versus modified) agreed in 83% (1230 of 1481) of cases; 99% (1471 of 1481) of cancers were within ±1 of their previous score. Of discordant cases, similar numbers of biopsies were upgraded and downgraded in the secondary review, with minor differences in the score distributions. Interobserver agreement was good, with κ values ranging from 0.62 (95% confidence interval [CI], 0.56–0.67) to 0.70 (95% CI, 0.65–0.76). The overall number of high-grade tumors (Gleason score 8–10; n = 48) remained constant between reviews, with 3 fewer cases in the placebo group (n = 16) and 3 more in the dutasteride group (n = 32) in the secondary review. When comparing the independent pathologist's modified scores versus the classic, 17 of 1481 cancers (1.1%) were upgraded (including 9 of 17 upgrades [53%] to high-grade tumors). Conclusions.—This analysis showed similar score distributions between the classic and modified Gleason scoring systems. The differences seen between the 2 pathologists' scores likely reflect differences in interpretation rather than the scoring system chosen.

scholarly journals Pathological correlation between needle biopsy and radical prostatectomy specimen in patients with localized prostate cancer

2012 ◽  
Vol 1 (3) ◽  
Author(s):  
Muhammad A. Bulbul ◽  
Yaser El-Hout ◽  
Maurice Haddad ◽  
Ayman Tawil ◽  
Ali Houjaij ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Positive Margins ◽  
Final Pathology ◽  
Bilateral Disease ◽  
Unilateral Disease ◽  
Group 2 ◽  
Group 1

Objective: This study aims to evaluate the accuracy of transrectal ultrasound (TRUS) guided prostate biopsies in predicting pathological grading and tumour distributionin the final pathological specimen of patients who underwent radical prostatectomy for clinically localized prostate cancer. The study ultimately aimsto gain more understanding of the pathological behaviour of prostate cancerand the limitations of the currently available diagnostic and prognostic tools.Material and Methods: We reviewed the records of 100 patients with localizedcarcinoma of the prostate diagnosed by TRUS-guided prostate biopsyand treated with radical retropubic prostatectomy, comparing tumour lateralityand Gleason score in core biopsies with tumour distribution and Gleasonscore of the surgical specimen. We then correlated both results to diagnosticand prognostic variables such as prostate specific antigen (PSA) values and surgical margins.Results: All 44 patients with bilateral disease on needle biopsy had bilateral diseaseon final pathology, with 15 of these patients (34%) having positive margins.Of the 56 patients with unilateral disease on biopsy, 37 (66%) had bilateral disease on final pathology; however, only 4 of them (7%) had positive margins (p < 0.001). Median Gleason score on final pathology was upgraded to 7, compared with a median score of 6 on biopsies. Stratifying patients to 2 groups based on their PSA level (group 1: PSA < 10 ng/mL, 72 patients; group2: PSA > 10ng/mL, 28 patients), revealed that 57patients (79%) in group 1and 24 patients (85%) in group 2 had bilateral disease. In addition, 13 patients(18%) in group 1 and 6 patients (21%) in group 2 had positive margins.Conclusions: Sixty-six percent of patients with unilateral disease on needlebiopsy had bilateral disease on final pathology, but this does not increasetheir rate of having positive margins. Gleason score is upgraded from 6 to7. PSA did not seem to affect laterality of disease in patients selected forradical prostatectomy.

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