Timing of Exchange of the Maxillary Deciduous and Permanent Teeth in Boys with Three Types of Orofacial Clefts

1996 ◽  
Vol 33 (4) ◽  
pp. 318-323 ◽  
Author(s):  
Miroslav Peterka ◽  
Renata Peterková ◽  
Zbyněk Likovský
Keyword(s):  
Permanent Teeth ◽  
Control Group ◽  
Orofacial Clefts ◽  
Maxillary Canine ◽  
Second Molar ◽  
Developmental Disturbances ◽  
Maxillary Lateral Incisor ◽  
Maxillary Premolars ◽  
Dental Plaster ◽  
Isolated Cleft Palate

Timing of exchange of the deciduous and permanent maxillary teeth was investigated using dental plaster casts of 163 boys with total unilateral cleft (UCLP), 82 boys with bilateral cleft (BCLP), and 97 boys with isolated cleft palate (CP). All patients were treated at the Prague Plastic Surgery Clinic. The results were compared with a control group of 294 schoolboys. To evaluate the course of eruption, the proportion of each erupted teeth in each year of age was employed. In boys with UCLP, eruption of the permanent maxillary lateral incisors and the permanent maxillary second molar was retarded on the cleft side. On the non-affected side, no delay of eruption was observed, but earlier eruption was found in the permanent maxillary canine and in the permanent maxillary first and second premolars. In boys with BCLP, the highest retardation of eruption was found in the permanent maxillary lateral incisor and in the permanent maxillary first molar. The permanent maxillary canine and both permanent maxillary premolars erupted earlier than in the control group. In boys with CP, only the permanent maxillary central incisors erupted earlier. The maxillary deciduous canines and the second molars were both lost early. We conclude that the developmental disturbances of the maxillary jaw and teeth in patients with orofacial clefts are also associated with alteration of timing of dental exchange.

scholarly journals Dental Development in Subjects with Thalassemia Major

2006 ◽  
Vol 7 (4) ◽  
pp. 63-70 ◽  
Author(s):  
Abdalla M. Hazza'a ◽  
Ghaida Al-Jamal
Keyword(s):  
Thalassemia Major ◽  
Permanent Teeth ◽  
Dental Development ◽  
Control Group ◽  
Dental Age ◽  
Second Molar ◽  
Maturity Score ◽  
Mean Delay ◽  
Significant Difference ◽  
The Mean

Abstract Aim The aim of this study was to evaluate the dental development of patients with â-thalassemia major and to compare it with unaffected children. Methods and Materials Panoramic radiographs of 44 thalassemic patients taken before the age of 16 years were examined. The subjects consisted of 29 males and 15 females ranging in age from 4.9 to 15.7 (mean = 10.8±2.9) years and 44 controls matched for age and sex. The seven left mandibular permanent teeth, second molar to central incisor, were rated on an eight stage scale using the methods described by Demirjian et al.10 The stage of each tooth was converted to the corresponding numeric value and then all values were added to obtain a dental maturity score which corresponded to a dental age. Dental and chronologic ages were compared using a paired t-test. The relationship between the chronologic age and the amount of delay was also determined. Results Thirty-nine patients had a delay in the development of their dentition. The mean developmental dental delay was found to be 1.01 years (p<0.05). The range in delay was from 0.1 to 2.9 years. There was no significant difference between the mean chronologic and dental age of the control group (p> 0.05). The amount of delay in dental development increases as the patient.s age increased (p<0.05). Males were found to have a greater delay (mean 1.16 years) than females (mean delay 0.73 years), but this difference was not statistically significant. Conclusions The delay in dental development in β-thalassemia major varied according to the patient.s age. This positive correlation parallels the general growth of thalassemic children. Citation Hazza.a AM, Al-Jamal G. Dental Development in Subjects with Thalassemia Major. J Contemp Dent Pract 2006 September;(7)4:063-070.

scholarly journals PAX7, PAX9 and RYK Expression in Cleft Affected Tissue

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1075
Author(s):  
Mārtiņš Vaivads ◽  
Ilze Akota ◽  
Māra Pilmane
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Rank Correlation ◽  
Control Group ◽  
Orofacial Clefts ◽  
Spearman’S Rank Correlation ◽  
Morphological Studies ◽  
Affected Tissue ◽  
Isolated Cleft Palate

Background and Objectives: Cleft lip with or without cleft palate is one of the most common types of congenital malformations. Transcription factors paired box 7 and 9 (PAX7, PAX9) and receptor-like tyrosine kinase (RYK) have been previously associated with the formation of orofacial clefts but their exact possible involvement and interactions in the tissue of specific cleft types remains uncertain. There is a limited number of morphological studies analyzing these specific factors in cleft affected tissue due to ethical aspects and the limited amount of available tissue material. This study analyses the presence of PAX7, PAX9, and RYK immunopositive structures within different cleft affected tissue to assess their possible involvement in cleft morphopathogenesis. Materials and Methods: Cleft affected tissue was collected from non-syndromic orofacial cleft patients during cleft correcting surgery (36 patients with unilateral cleft lip, 13 patients with bilateral cleft lip, 26 patients with isolated cleft palate). Control group oral cavity tissue was obtained from 7 patients without cleft lip and palate. To evaluate the number of immunopositive structures in the cleft affected tissue and the control group, a semiquantitative counting method was used. Non-parametric statistical methods (Kruskal–Wallis H test, Mann–Whitney U test, and Spearman’s rank correlation) were used. Results: Statistically significant differences for the number of PAX7, PAX9, and RYK-positive cells were notified between the controls and the patient groups. Multiple statistically significant correlations between the factors were found in each cleft affected tissue group. Conclusions: PAX7, PAX9, and RYK have a variable involvement and interaction in postnatal morphopathogenesis of orofacial clefts. PAX7 is more associated with the formation of unilateral cleft lip, while PAX9 relates more towards the isolated cleft palate. The stable presence of RYK in all cleft types indicates its possible participation in different facial cleft formations.

scholarly journals The prevalence of peg-shaped and missing lateral incisors with maxillary impacted canines

2019 ◽  
Vol 76 (1) ◽  
pp. 61-71 ◽  
Author(s):  
Sanja Simic ◽  
Jasna Pavlovic ◽  
Predrag Nikolic ◽  
Amila Vujacic ◽  
Vladanka Vukicevic ◽  
...  
Keyword(s):  
T Test ◽  
Lateral Incisor ◽  
Control Group ◽  
Maxillary Canine ◽  
Normal Morphology ◽  
Impacted Canines ◽  
Maxillary Lateral Incisor ◽  
Digital Measurements ◽  
Maxillary Incisors ◽  
Criteria For Selection

Background/Aim. Many authors find that impacted maxillary canines is associated with missing and peg-shaped lateral incisor. The aim of this study was to examine the prevalence of peg-shaped and missing lateral incisor in subjects with impacted maxillary canines, and compare the size of maxillary lateral incisor on the side with palatally impacted canines and on the opposite side of the jaw where there is no impaction. Methods. The study included 64 patients with 80 impacted maxillary canines (23 males and 41 females, mean age 16.3). For each maxillary unerupted canine, precisely correct localization and classification into groups was done. We analyzed the morphology of the lateral incisor (normal, atypical) and frequency of missing of lateral maxillary incisors with canine impaction. Then, from the mentioned examinees sample with the maxillary canine teeth, a subgroup was formed. The criteria for selection were those with unilateral palatally impacted canines (33 subjects, 22 females and 11 males, mean age 17.8 years). The linear variables of the maxillary lateral incisor were measured by using digital measurements tools. The t-test was used to test the differences between the groups. Results. Normal morphology of the lateral incisors was found in 72% of the subjects with the impacted canines, 11.2% of the subjects had the peg-shaped lateral incisors, 6% had a bilateral and 4% had unilateral deficiency of lateral incisors. In the subgroup of the patients with unilateral palatal impaction, the middle value of the length of the lateral incisors was 1.9 mm shorter and the middle value of the width of the lateral incisors was smaller by 0.9 mm when comparing to the control group. Conclusion. The frequency of the deficiency of lateral incisors was statistically significantly higher in the group with palatal canine impaction. The maxillary lateral incisors on the side with palatally impacted canines were smaller than those on the side where there was no impaction.

Dental Subphenotypes in Infants With Orofacial Clefts—A Longitudinal Population-Based Retrospective Radiographic Study of the Primary and Secondary Dentitions

2021 ◽  
pp. 105566562199014
Author(s):  
Mimi Yow ◽  
Nuno V. Hermann ◽  
Yuan Wei ◽  
Agneta Karsten ◽  
Sven Kreiborg
Keyword(s):  
Cleft Lip ◽  
Population Based ◽  
Dental Anomalies ◽  
Orofacial Clefts ◽  
Developmental Patterns ◽  
Dental Maturation ◽  
Northern European ◽  
Maxillary Lateral Incisor ◽  
Isolated Cleft Palate ◽  
Historical Controls

Objectives: To determine the developmental patterns of primary and secondary dentitions in infants with orofacial clefts. Design: Retrospective, longitudinal, population-based cohort study. Materials: Longitudinal records and radiographs of 192 nonsyndromic Northern European infants with isolated unilateral cleft lip (UCL, n = 111) and isolated cleft palate (CP, n = 81). Methods: Radiographic assessments of primary and secondary dentition anomalies and dental maturation, by gender and cleft severity for comparisons between the groups and with historical controls. Results: In infants with UCL, the frequencies of dental anomalies were high in both primary (38.7%) and secondary (18.0%) dentitions. Primary and secondary dentition anomalies were not observed in infants with CP and different in the UCL group ( P = .003). Risk differences involved primary supernumerary teeth ( P = .0001) and talon cusp formation ( P = .0001), and secondary tooth agenesis ( P = .001) of the maxillary lateral incisor on the side of the cleft lip. Delayed primary and secondary dental maturation occurred in the UCL and CP groups, greater in infants with UCL ( P < .0001). Primary and secondary dental maturation featured sexual dimorphism with greater delay in males (UCL, P < .0001; CP, .0001 > P = .001). The effect of cleft severity on dental maturation was significant in infants with UCL ( P = .0361) and CP ( P = .0175) in the primary but not in the secondary dentition. Conclusions: There were different dental anomalies in the primary and secondary dentitions in operated infants with UCL and no dental anomalies in unoperated infants with CP. Dental maturation was delayed in infants with UCL and CP with greater delay in males compared to females.

scholarly journals Comparative evaluation of osteogenic differentiation potential of stem cells derived from dental pulp and exfoliated deciduous teeth cultured over granular hydroxyapatite based scaffold

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Manal Nabil Hagar ◽  
Farinawati Yazid ◽  
Nur Atmaliya Luchman ◽  
Shahrul Hisham Zainal Ariffin ◽  
Rohaya Megat Abdul Wahab
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
3D Culture ◽  
Permanent Teeth ◽  
Deciduous Teeth ◽  
Osteogenic Potential ◽  
Control Group ◽  
Rt Pcr ◽  
Differentiation Potential

Abstract Background Mesenchymal stem cells isolated from the dental pulp of primary and permanent teeth can be differentiated into different cell types including osteoblasts. This study was conducted to compare the morphology and osteogenic potential of stem cells from exfoliated deciduous teeth (SHED) and dental pulp stem cells (DPSC) in granular hydroxyapatite scaffold (gHA). Preosteoblast cells (MC3T3-E1) were used as a control group. Methodology The expression of stemness markers for DPSC and SHED was evaluated using reverse transcriptase-polymerase chain reaction (RT-PCR). Alkaline phosphatase assay was used to compare the osteoblastic differentiation of these cells (2D culture). Then, cells were seeded on the scaffold and incubated for 21 days. Morphology assessment using field emission scanning electron microscopy (FESEM) was done while osteogenic differentiation was detected using ALP assay (3D culture). Results The morphology of cells was mononucleated, fibroblast-like shaped cells with extended cytoplasmic projection. In RT-PCR study, DPSC and SHED expressed GAPDH, CD73, CD105, and CD146 while negatively expressed CD11b, CD34 and CD45. FESEM results showed that by day 21, dental stem cells have a round like morphology which is the morphology of osteoblast as compared to day 7. The osteogenic potential using ALP assay was significantly increased (p < 0.01) in SHED as compared to DPSC and MC3T3-E1 in 2D and 3D cultures. Conclusion gHA scaffold is an optimal scaffold as it induced osteogenesis in vitro. Besides, SHED had the highest osteogenic potential making them a preferred candidate for tissue engineering in comparison with DPSC.

Comparison of Dental Caries Prevalence in Patients with Cleft Lip and/or Palate and Their Sibling Controls

2009 ◽  
Vol 46 (5) ◽  
pp. 529-531 ◽  
Author(s):  
Mahmoud Al-Dajani
Keyword(s):  
Dental Caries ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillofacial Surgery ◽  
Permanent Teeth ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Caries Prevalence ◽  
Dmft Index ◽  
And Control

Objective: To evaluate the prevalence of dental caries in patients with cleft lip and/or palate and their cleft-free sibling controls. Methods: The two subject groups (patient and control) comprised 106 participants. The former group consisted of 53 patients with cleft lip and/or palate, aged 12 to 29 years, who visited the Oral and Maxillofacial Surgery Hospital at Damascus University of Syria. The control group consisted of the patients’ siblings who had no clefts, and they were sex matched to the patient group. Dental caries were examined clinically and were reported using the decayed, missing, and filled permanent teeth (DMFT) index. The DMFT scores were compared between the two groups. Results: The author found an overall association of dental caries with the presence of cleft lip and/or palate (odds ratio  =  2.52; 95% confidence interval  =  1.389–4.574; p < .05). The DMFT index scores were proportionally higher in patients with cleft lip and/or palate compared with the control group (p < .001). Conclusion: Subjects with cleft lip and palate are susceptible to dental caries independently of socioeconomic status.

scholarly journals Case-control study of oral disease indexes in individuals with head and neck cancer after antineoplastic therapy

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Reyna Aguilar Quispe ◽  
Adrielle Lindolpho Cremonesi ◽  
Jeanne Kelly Gonçalves ◽  
Cassia Maria Fischer Rubira ◽  
Paulo Sérgio da Silva Santos
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Permanent Teeth ◽  
Control Group ◽  
Study Group ◽  
Periodontal Index ◽  
Community Periodontal Index ◽  
History Of ◽  
Antineoplastic Treatment

ABSTRACT Objective To evaluate the oral health of patients with head and neck cancer after antineoplastic treatment, and to compare them with patients with no history of cancer. Methods A total of 75 patients, divided into Study Group, composed of individuals after antineoplastic treatment (n=30), and Control Group, with individuals with no history of cancer (n=45), aged 37 to 79 years. The oral health status was evaluated through the index of decayed, missing or filled permanent teeth (DMFT), community periodontal index and evaluation of the use and need of prosthesis. All of these items were evaluated according to the criteria recommended by the World Health Organization. The statistical analysis was descriptive and used the Pearson’s χ2 test. Results The community periodontal index was higher in the Study Group when compared to the Control Group (p<0.0001). The need for an upper (p<0.001) and lower (p<0.0001) prostheses was higher in the Study Group. Also, the use of upper prosthesis was higher in the Study Group (p<0.002). The missing or filled permanent teeth index between the two groups (p>0.0506) and the use of lower prosthesis (p>0.214) did not present a relevant statistical difference. Conclusion Periodontal disease and edentulism are the most significant changes in individuals who received antineoplastic therapy for head and neck cancer as well as greater need for oral rehabilitation.

Incidence of Lower Second Permanent Molar Impaction

1988 ◽  
Vol 15 (3) ◽  
pp. 199-203 ◽  
Author(s):  
Ruth Evans
Keyword(s):  
Deciduous Teeth ◽  
Control Group ◽  
Second Molar ◽  
Permanent Molar ◽  
Two Samples ◽  
Orthodontic Patients

The incidence of lower second molar impaction was investigated, comparing the records of two samples of 200 orthodontic patients referred consecutively, in 1976 and 1986. A further study compared 50 cases showing both bilateral and unilateral impactions, with a non-impacted control group. This allowed possible causes of the impactions to be examined, particularly concerning the effect of premature loss of deciduous teeth on the distribution of crowding.

An in Vivo Comparison of Antimicrobial Efficacy of Sodium Hypochlorite and Biopure MTAD™ against Enterococcus Faecalis in Primary Teeth: A qPCR Study

2014 ◽  
Vol 39 (1) ◽  
pp. 30-34 ◽  
Author(s):  
SG Tulsani ◽  
N Chikkanarasaiah ◽  
S Bethur
Keyword(s):  
Root Canal ◽  
Primary Teeth ◽  
Antimicrobial Efficacy ◽  
Permanent Teeth ◽  
Control Group ◽  
Statistical Significant Difference ◽  
Anterior Teeth ◽  
Significant Difference ◽  
Root Canal Irrigant

Objectives: Biopure MTAD™, a new root canal irrigant has shown promising results against the most common resistant microorganism, E. faecalis, in permanent teeth. However, there is lack of studies comparing its antimicrobial effectiveness with NaOCl in primary teeth. The purpose of this study was to compare the in vivo antimicrobial efficacy of NaOCl 2.5% and Biopure MTAD™ against E. faecalis in primary teeth. Study design: Forty non vital single rooted primary maxillary anterior teeth of children aged 4-8 years, were irrigated either with NaOCl 2.5% (n=15), Biopure MTAD™ (n=15) and 0.9% Saline (n=10, control group). Paper point samples were collected at baseline (S1) and after chemomechanical preparation (S2) during the pulpectomy procedure. The presence of E. faecalis in S1 & S2 was evaluated using Real time Polymerase Chain Reaction. Results: Statistical significant difference was found in the antimicrobial efficacy of NaOCl 2.5 % and BioPure MTAD™ when compared to saline (p&gt;0.05). However, no statistical significant difference was found between the efficacies of both the irrigants. Conclusions: NaOCl 2.5% and BioPure MTAD™, both irrigants are equally efficient against E. faecalis in necrotic primary anterior teeth. MTAD is a promising irrigant, however clinical studies are required to establish it as ideal root canal irrigant in clinical practice.

Dental anomalies frequency in submucous cleft palate versus complete cleft palate

2021 ◽  
Author(s):  
João Paulo Schwartz ◽  
Daniela Gamba Garib
Keyword(s):  
Cleft Palate ◽  
Permanent Teeth ◽  
Tooth Agenesis ◽  
Dental Anomalies ◽  
Supernumerary Teeth ◽  
Chi Square ◽  
Intergroup Comparison ◽  
Significant Difference ◽  
Submucous Cleft Palate ◽  
Isolated Cleft Palate

Summary Background/Objectives This retrospective study evaluated the prevalence of dental anomalies of number in different subphenotypes of isolated cleft palate. Materials/Methods The sample comprised 26 individuals with submucous cleft palate (group S) and 68 individuals with complete cleft palate (group C) aged between 9 and 12 years from a single centre. Panoramic radiographs were evaluated regarding the presence of dental anomalies of number in permanent teeth. Intergroup comparison was performed using chi-square tests (P &lt; 0.05). Results Tooth agenesis was found in 34.61 and 36.76 per cent of group S and group C, respectively. The most commonly missing teeth were the maxillary second premolar, maxillary lateral incisor, and mandibular second premolar. Supernumerary teeth were found in none and 1.47 per cent of the individuals with submucous and complete cleft palate, respectively. No statistically significant difference was found between groups for the frequency of tooth agenesis and supernumerary teeth. Limitations Only dental anomalies of number were evaluated. Conclusions/Implications Individuals with submucous and complete cleft palate showed similar prevalence for tooth agenesis and supernumerary teeth. Dental anomalies frequency seems not to be a discriminator for subphenotypes of cleft palate.

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