Exemplar Abstract for Ureaplasma urealyticum Shepard et al. 1974 (Approved Lists 1980) emend. Robertson et al. 2002.

Background and Purpose: Lactobacilli play a vital role in protecting the vagina against pathogens. Cytokines are vital components of defense against infections in women. The genital mycoplasmas, Mycoplasma genitalium and Ureaplasma urealyticum, are associated with various infectious diseases in adults and infants. The objective of our study is to identify differences in cytokine profile and Lactobacillus species dominance between a study group of non-pregnant pre-menopausal women with genital M. genitalium or U. urealyticum colonization and a control group of non-pregnant pre-menopausal women without genital M. genitalium or U. urealyticum colonization. Methods: A real-time polymerase chain reaction was performed to measure Lactobacillus species in vaginal swab samples. Cytokine analysis was performed using multiplex immunoassay techniques. Analysis of variance confirmed a significant difference in cytokine profiles between patient groups, with t-tests identifying the most significantly different cytokines. Categorical data analysis identified significant patterns of relative Lactobacillus species dominance in the study group. Results: Lactobacillus iners was the predominant Lactobacillus species in the control group ( p = 0.005). There were no dominant Lactobacillus species observed in the study group. Vascular endothelial growth factor A ( p = 0.002), interleukin-8 ( p = 0.001), and interleukin-1β ( p = 0.049) were expressed significantly higher in the study group, whereas interleukin-1 receptor antagonist ( p < 0.001), interleukin-10 ( p = 0.001), interleukin-12 ( p = 0.002), and interferon-γ ( p = 0.022) were expressed higher in the control group. Association matrices for cytokines were significantly different between two groups ( p < 0.001), with mostly negative associations in the control group and mostly positive associations in the study group. Conclusion: Cytokine levels, their associations, and the patterns of Lactobacillus species dominance are observed to significantly diverge on the basis of M. genitalium and U. urealyticum colonization among non-pregnant pre-menopausal women.

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Infection of Ureaplasma urealyticum in the group of full-term infants

Early Human Development ◽

10.1016/j.earlhumdev.2008.09.117 ◽

2008 ◽

Vol 84 ◽

pp. S46

Author(s):

Jolanta Uchman

Keyword(s):

Ureaplasma Urealyticum ◽

Full Term ◽

Term Infants

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The significance of Ureaplasma urealyticum as a pathogenic agent in the paediatric population

Current Opinion in Infectious Diseases ◽

10.1097/01.qco.0000224824.73223.e7 ◽

2006 ◽

Vol 19 (3) ◽

pp. 283-289 ◽

Cited By ~ 26

Author(s):

Georgia S Pinna ◽

Chrysanthi L Skevaki ◽

Dimitris A Kafetzis

Keyword(s):

Ureaplasma Urealyticum ◽

Paediatric Population ◽

Pathogenic Agent

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Chlamydia trachomatis and urogenital mycoplasms in nonconococcal urethirits in men

Medicinski pregled ◽

10.2298/mpns1002047v ◽

2010 ◽

Vol 63 (1-2) ◽

pp. 47-50

Author(s):

Sonja Vesic ◽

Jelica Vukicevic ◽

Eleonora Gvozdenovic ◽

Dusan Skiljevic ◽

Slobodanka Janosevic ◽

...

Keyword(s):

Chlamydia Trachomatis ◽

Ureaplasma Urealyticum ◽

Mycoplasma Hominis ◽

Sexually Active ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Nongonococcal Urethritis ◽

Etiological Agents ◽

The One

Introduction. Nongonococcal urethritis is the most common sexually transmitted infection in men, with vast majority of the etiological agents such as Chlamydia trachomatis, followed by urogenital mycoplasmas. The aim of this study was to determine the prevalence of Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis in nongonococcal urethritis in men, and to examine infections associated with these agents. Material and methods. 299 sexually active, heterosexual men with nongonococcal urethritis were included into the study. Urethral samples were taken with a dacron swab placed into the urethra up to 2-3 cm. The Direct immunojluorescence tehnique was performed for identification of Chlamydia trachomatis. Ureaplasma urealyticum and Mycoplasma hominis were detected with Mycoplasma 1ST assay. Results. Chlamydia trachomatis was detected in 22.75%, Uraeplasma urealyticum in 21.08% and Mycoplasma hominis in 8.02% cases. We found no significant differences in prevalence between Chlamydia trachomatis and Ureaplasma urealyticym (p>0.05). Monoinjections were found in 51.85% with significantly higher rate (p<0.01) than associated infections (11.70%). Among associated infections, coinfection of Chlamydia trahomatis and Ureaplasma urealyticum was predominant. Association of Chlamydia trachomatis with urogenital mycoplasmas was significantly higher (p<0.05) than the one between Ureaplasma urealyticum and Mycoplasma hominis. In 36.45% patients no patogenic microorganisms were detected. Conclusion. These results confirmed the etiological role of Chlamydia trachomatis and urogenital mycoplasmas in nongonococcal urethritis with prevalence of 51.85% in monoinfections and 11.70% in associated infections. In 36.45% of cases the etiology of urethritis was not elucidated. These results suggest that more sensitive diagnostic tool should be applied when searching for the detailed etiology of nongonococcal urethritis.

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