Plasma Medicine in Dermatology: Basic Antimicrobial Efficacy Testing as Prerequisite to Clinical Plasma Therapy

Hitherto, there is no proper line of treatment for the new (nCOVID19). The development of unique antiviral drugs has taken precedence. Therapeutic antibodies () will be a significantly beneficial agent against nCOVID-19. Here the host immune responses to new discussed in this review provide strategy and further treatment and understanding of clinical interventions against nCOVID-19. Plasma therapy uses the antibodies found in the blood of people recovering (or convalesced) from an infection to treat infected patients. When an infection occurs, the body begins producing proteins specially made to kill the germ, called antibodies. Those antibodies coat specifically plasma in the blood of survivors, the yellow transparent liquid blood portion for months or even years. research assesses plasma use from Convalescent patients of infected with nCOVID-19 as a possible preventive treatment. But it is not yet recommended as a line of treatment, and it is used as a clinical trial in the new in Indian population.

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Faculty Opinions recommendation of Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13348956.14719054 ◽

2011 ◽

Author(s):

Laura Piddock

Keyword(s):

Antimicrobial Efficacy

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Plasma therapy a possible hope to fight against COVID-19

10.35543/osf.io/yhq7v ◽

2020 ◽

Author(s):

Ravikant Piyush ◽

Aroni Chatterjee ◽

Shashikant Ray

Keyword(s):

Middle East ◽

Severe Acute Respiratory Syndrome ◽

Viral Disease ◽

Plasma Therapy ◽

Therapeutic Drugs ◽

Wild Fire ◽

The World ◽

Short Span ◽

Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

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The novel use of convalescent plasma in patients with COVID 19 in Basra governorate, Case series review

Iraqi National Journal of Medicine ◽

10.37319/iqnjm.2.csi.1 ◽

2020 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Saad Hammadi ◽

Ali Hashim ◽

Abbas Ali ◽

Rafid Abbood ◽

Hassanein Ali ◽

...

Keyword(s):

Plasma Exchange ◽

Case Series ◽

Passive Immunity ◽

The Novel ◽

Efficacy And Safety ◽

Off Label Use ◽

Plasma Therapy ◽

Off Label ◽

Plasma Donation ◽

Patient Series

Background: The idea of convalescent plasma usage is to give passive immunity to the patients, so their immune system stands a good chance of combating the virus.this study will review 6 cases of eligible covid 19 patients that had been treated with convalescent plasma therapy in Basra covid 19 quarantine Objectives: to demonstrate efficacy and safety of convalescent plasma in the patient series that had been enrolled . Method: this study had pioneered a new method to collect up to 3,000 mL in one session by an off-label use of Spectra Optia Apheresis systems by TerumoBCT /Exchange set to collect convalescent plasma. In this study 250 mL convalescent plasma had been given each of the 6 patients, from one donor. respose in spo2,dyspnoea and tachypnoea was observed ,any reaction to plasma also had been monitored . Result: Our case series have demonstrated both safety and effectiveness of convalescent plasma. This study was successful in reaching our primary and secondary outcomes in all 6 patients (improvement in SpO2 and symptoms). With negligible difference in time of post transfusion response Conclusion: convalescent plasma is apperantly safe and effective, In this study 250 mL convalescent plasma had been given each of the 6 patients, from one donor using Therapeutic Plasma Exchange (TPE) protocol by Spectra Optia Apheresis system/TerumoBCT. Keywords: convalescent plasma, COVID-19, SARS CoV-2, apheresis, plasma exchange, plasma donation

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Clinical Characteristics and Convalescent Plasma Therapy in Severe and Critically Ill COVID-19 Patients

SSRN Electronic Journal ◽

10.2139/ssrn.3576894 ◽

2020 ◽

Cited By ~ 2

Author(s):

Xiaowei Yang ◽

Yi Sui ◽

Fangfang Liu ◽

Zhanfang Kang ◽

Shangling Wu ◽

...

Keyword(s):

Critically Ill ◽

Clinical Characteristics ◽

Plasma Therapy

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