scholarly journals The High Incidence of the Emergence of Entecavir-Resistant Mutants among Patients Infected with Lamivudine-Resistant Hepatitis B Virus

2007 ◽  
Vol 213 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Futoshi Nagasaki ◽  
Hirofumi Niitsuma ◽  
Yoshiyuki Ueno ◽  
Jun Inoue ◽  
Takayuki Kogure ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
B Virus ◽  
High Incidence ◽  
Resistant Mutants

scholarly journals Sensitivity of drug-resistant mutants of hepatitis B virus to poly-IC

2014 ◽  
Vol 58 (04) ◽  
pp. 348-355
Author(s):  
Q. ZHOU ◽  
E. CHEN ◽  
L. CHEN ◽  
Y. NONG ◽  
X. CHENG ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Drug Resistant ◽  
B Virus ◽  
Resistant Mutants

scholarly journals High incidence of treatment-induced and vaccine-escape hepatitis B virus mutants among human immunodeficiency virus/hepatitis B-infected patients

Hepatology ◽  
2013 ◽  
Vol 58 (3) ◽  
pp. 912-922 ◽  
Author(s):  
Karine Lacombe ◽  
Anders Boyd ◽  
Fabien Lavocat ◽  
Christian Pichoud ◽  
Joel Gozlan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Hepatitis ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
High Incidence

Adoption of Hepatitis B Virus-Infected Foreign-Born Children

PEDIATRICS ◽  
1990 ◽  
Vol 85 (5) ◽  
pp. 890-891
Author(s):  
RONALD J. SOKOL
Keyword(s):  
United States ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
South America ◽  
The United States ◽  
Hbv Infection ◽  
Foreign Born ◽  
B Virus ◽  
High Incidence ◽  
Central South

To the Editor.— Hostetter et al1 confirmed recent reports2-5 of the relatively high incidence of hepatitis B virus (HBV) infection among foreign-born children who are adopted in the United States. Approximately 5% to 15% of adopted infants from Asia, India, and Central/South America are found to have active HBV infection or to be asymptomatic carriers.1-5 Although some information is provided to prospective parents by adoption agencies discussing the possibility of a number of diseases (including HBV infection) in the foreign-born infants, few parents, in our experience, felt that they were adequately informed about the true risk and the potential social and medical consequences of HBV infection before the placement of the child in their home.

scholarly journals In Vitro Activity of 2,4-Diamino-6-[2-(Phosphonomethoxy)Ethoxy]-Pyrimidine against Multidrug-Resistant Hepatitis B Virus Mutants

2007 ◽  
Vol 51 (6) ◽  
pp. 2240-2243 ◽  
Author(s):  
M. N. Brunelle ◽  
J. Lucifora ◽  
J. Neyts ◽  
S. Villet ◽  
A. Holy ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
In Vitro Activity ◽  
B Virus ◽  
Pyrimidine Analogue ◽  
Resistant Strains ◽  
Resistant Mutants

ABSTRACT The susceptibilities of drug-resistant hepatitis B virus (HBV) mutants to lamivudine, adefovir, tenofovir, entecavir, and 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine (PMEO-DAPym), a novel acyclic pyrimidine analogue, were assessed in vitro. Most drug-resistant mutants, including multidrug-resistant strains, remained sensitive to tenofovir and PMEO-DAPym. Therefore, the latter molecule deserves further evaluation for the treatment of HBV infection.

Adefovir Dipivoxil for Treatment of Breakthrough Hepatitis Caused by Lamivudine-Resistant Mutants of Hepatitis B Virus

Intervirology ◽  
2004 ◽  
Vol 47 (6) ◽  
pp. 362-369 ◽  
Author(s):  
Tetsuya Hosaka ◽  
Fumitaka Suzuki ◽  
Yoshiyuki Suzuki ◽  
Satoshi Saitoh ◽  
Masahiro Kobayashi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Adefovir Dipivoxil ◽  
B Virus ◽  
Resistant Mutants ◽  
Breakthrough Hepatitis

scholarly journals Novel Nucleoside Analogue MCC-478 (LY582563) Is Effective against Wild-Type or Lamivudine-Resistant Hepatitis B Virus

2002 ◽  
Vol 46 (8) ◽  
pp. 2602-2605 ◽  
Author(s):  
Suzane Kioko Ono-Nita ◽  
Naoya Kato ◽  
Yasushi Shiratori ◽  
Flair José Carrilho ◽  
Masao Omata
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleoside Analogue ◽  
Blot Hybridization ◽  
Southern Blot Hybridization ◽  
Hbv Dna ◽  
Wild Type ◽  
Human Hepatoma Cells ◽  
B Virus ◽  
Resistant Mutants

ABSTRACT The emergence of resistant hepatitis B virus (HBV) with the L528M mutation and/or the M552V and M552I mutations in the polymerase gene following long-term lamivudine treatment is becoming an important clinical problem. The aim of this study was to investigate the susceptibility of wild-type and lamivudine-resistant HBV to MCC-478 (LY582563), a novel nucleoside analogue derivative of phosphonomethoxyethyl purine. The susceptibility of wild-type HBV and lamivudine-resistant mutants (M552I, M552V, and L528M/M552V) to MCC-478 was examined by transient transfection of full-length HBV DNA into human hepatoma cells. HBV DNA replication was monitored by Southern blot hybridization, and the effective concentration required to reduce replication by 50% (EC50) was determined. The replicative intermediates of wild-type and lamivudine-resistant mutants were progressively diminished by treatment with increasing doses of MCC-478. The MCC-478 EC50s were 0.027 μM for wild-type HBV (about 20 times more efficient than lamivudine), 2.6 μM for M552I, 3.3 μM for M552V, and 2.0 μM for L528M/M552V. Wild-type HBV and lamivudine-resistant mutants are susceptible to MCC-478. MCC-478 appears to be a candidate for the treatment of HBV infection and exhibits potent activity against lamivudine-resistant HBV.

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