scholarly journals Knowledge, Experience, and Perceptions of Generic Drugs among Middle-Aged Adults and their Willingness-to-Pay: A Nationwide Online Survey in Japan

2021 ◽  
Vol 255 (1) ◽  
pp. 9-17
Author(s):  
Yuki Ito ◽  
Konan Hara ◽  
Hajime Sato ◽  
Jun Tomio
Author(s):  
Qing Huang ◽  
Mingxin Hu ◽  
Hongliang Chen

The pervasiveness of smartphones and the popularity of short-form video applications (SVAs), such as TikTok, among middle-aged Chinese adults have raised concerns about problematic SVAs use. Although a plethora of research has examined problematic smartphone use among teenagers and young adults, scarce attention has been paid to the middle-aged group. This study integrates the psychopathological approach and the compensatory use approach to explicate problematic SVAs use among middle-aged Chinese adults. We aim to examine the relationship between stress and problematic SVAs use via the mediating roles of duration of use and flow experience. A total of 194 middle-aged adults from across the nation participated in an online survey. The results showed that stress was positively associated with problematic SVAs use. We also found that duration of use positively mediated the relationship between stress and problematic SVAs use. Furthermore, a serial mediation effect of duration of use and flow experience was found. The findings suggest that the aforementioned two approaches are complementary to each other in explicating problematic SVAs use, but the compensatory use approach explains more than the psychopathological approach does. Flow experience extends the original compensatory use approach and demonstrates the importance of incorporating techno-psychological predictors in understanding problematic SVAs use.


Open Heart ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. e001047 ◽  
Author(s):  
Howard Thom ◽  
Alexandru Ciprian Visan ◽  
Edna Keeney ◽  
Dan Mihai Dorobantu ◽  
Daniel Fudulu ◽  
...  

ObjectivesIn young and middle-aged adults, there are three current options for aortic valve replacement (AVR), namely mechanical AVR (mechAVR), tissue AVR (biological AVR) and the Ross operation, with no clear guidance on the best option. We aim to compare the clinical effectiveness and cost-effectiveness of the Ross procedure with conventional AVR in young and middle-aged adults.MethodsThis is a systematic literature review and meta-analysis of AVR options. Markov multistate model was adopted to compare cost-effectiveness. Lifetime costs, quality-adjusted life years (QALYs), net monetary benefit (NMB), population expected value of perfect information (EVPI) and expected value of partial perfect information were estimated.ResultsWe identified 48 cohorts with a total number of 12 975 patients (mean age 44.5 years, mean follow-up 7.1 years). Mortality, bleeding and thromboembolic events over the follow-up period were lowest after the Ross operation, compared with mechAVR and biological AVR (p<0.001). Aortic reoperation rates were lower after Ross compared with biological AVR, but slightly higher when compared with mechAVR (p<0.001). At a willingness-to-pay threshold of £20effective. At a willingness-to-pay threshold of £20, 000 per QALY000 per QALY, the Ross procedure is more cost-effective compared the Ross procedure is more cost-effective compared withwith conventional AVR, with a lifetime incremental NMB of £60 conventional AVR, with a lifetime incremental NMB of £60 952 (952 (££3030 236236 to to ££7979 464). Incremental costs were £12464). Incremental costs were £12 323 (323 (££61086108 to to ££1515 972) and incremental QALYs 3.66 (1.81972) and incremental QALYs 3.66 (1.81 to to 4.76). The population EVPI indicates that a trial costing up to £2.03 million could be cost 4.76). The population EVPI indicates that a trial costing up to £2.03 million could be cost--effective.At a willingness-to-pay threshold of £20 000 per QALY, the Ross procedure is more cost-effective compared with conventional AVR, with a lifetime incremental NMB of £60 952 (£30 236 to £79 464). Incremental costs were £12 323 (£6108 to £15 972) and incremental QALYs 3.66 (1.81 to 4.76). The population EVPI indicates that a trial costing up to £2.03 million could be cost-effective.ConclusionsIn young and middle-aged adults with aortic valve disease, the Ross procedure may confer greater quality of life and be more cost-effective than conventional AVR. A high-quality randomised trial could be warranted and cost-effective.


2020 ◽  
pp. 136078042098076
Author(s):  
Otto Simonsson ◽  
Stephen Fisher ◽  
Maryanne Martin

In recent years, the practice of mindfulness has become increasingly popular, but there is very little evidence on how many and what kind of people have heard of and learnt to practise mindfulness. Using data from an online survey on a sample of 1013 adults in Britain in November 2018, this study aims to estimate the prevalence of mindfulness use among adults in Britain and to identify the sociodemographic and political characteristics associated with awareness and experience of mindfulness. The findings suggest that 15% of adults in Britain had learnt to practise mindfulness, which is significantly more than the finding that 2.5% of adults in the United States in 2012 had practised mindfulness in their lifetime. Although widespread, awareness of mindfulness was more common among women, unmarried adults, adults from middle and high-income households, and those who voted Remain in the 2016 Brexit Referendum. Higher levels of engagement with mindfulness, beyond awareness, were more likely among young and middle-aged adults, but otherwise not concentrated in any particular groups.


Author(s):  
Hyuma Makizako ◽  
Ryoji Kiyama ◽  
Daisaku Nishimoto ◽  
Ikuko Nishio ◽  
Tomomi Masumitsu ◽  
...  

Regular exercise may be associated with better self-rated health and sleep status. However, this correlation among various age groups, such as young, middle-aged, and older people, as well as during the COVID-19 pandemic, has not been examined. This study examined the correlation between regular exercise and self-rated health and sleep quality among adults in Japan during the COVID-19 pandemic. Data were collected using an online survey conducted between February 26 and 27, 2021. A total of 1410 adults in Japan (age range, 20–86 years) completed the online survey. Regular exercise was divided into: (1) more than 30 min of moderate exercise a day, (2) more than 2 days per week, and (3) continuous for 1 year or longer. Self-rated health and sleep quality were assessed using the Likert scale. After adjusting for multiple confounders, regular exercise was correlated with decreased poor self-rated health and poor sleep quality in middle-aged adults; however, no significant correlation was observed among young and older adults. The promotion of regular exercise among middle-aged people during the COVID-19 pandemic may contribute to better self-rated health and sleep quality status.


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