scholarly journals Analysis of the fibroblast growth factor receptor 1/klotho beta (Fgfr1/Klb1)-dependent transcriptome in brown adipose tissue (BAT) from a mouse model of diet-induced obesity

Author(s):  
MJ Brauer
2020 ◽  
Vol 105 (3) ◽  
pp. e520-e531 ◽  
Author(s):  
Lijuan Sun ◽  
Jianhua Yan ◽  
Hui Jen Goh ◽  
Priya Govindharajulu ◽  
Sanjay Verma ◽  
...  

Abstract Background Adipocyte-derived hormones play a role in insulin sensitivity and energy homeostasis. However, the relationship between circulating fibroblast growth factor 21 (FGF21), adipocytokines and cold-induced supraclavicular brown adipose tissue (sBAT) activation is underexplored. Objective Our study aimed to investigate the relationships between cold-induced sBAT activity and plasma FGF21 and adipocytokines levels in healthy adults. Design Nineteen healthy participants underwent energy expenditure (EE) and supraclavicular infrared thermography (IRT) within a whole-body calorimeter at baseline and at 2 hours post-cold exposure. 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography/magnetic resonance (PET/MR) imaging scans were performed post-cold exposure. PET sBAT mean standardized uptake value (SUV mean), MR supraclavicular fat fraction (sFF), anterior supraclavicular maximum temperature (Tscv max) and EE change (%) after cold exposure were used to quantify sBAT activity. Main Outcome Measures Plasma FGF21, leptin, adiponectin, and tumor necrosis factor alpha (TNFα) at baseline and 2 hours post-cold exposure. Body composition at baseline by dual-energy x-ray absorptiometry (DXA). Results Plasma FGF21 and adiponectin levels were significantly reduced after cold exposure in BAT-positive subjects but not in BAT-negative subjects. Leptin concentration was significantly reduced in both BAT-positive and BAT-negative participants after cold exposure. Adiponectin concentration at baseline was positively strongly associated with sBAT PET SUV mean (coefficient, 3269; P = 0.01) and IRT Tscv max (coefficient, 6801; P  = 0.03), and inversely correlated with MR sFF (coefficient, −404; P  = 0.02) after cold exposure in BAT-positive subjects but not in BAT-negative subjects. Conclusion Higher adiponectin concentrations at baseline indicate a greater cold-induced sBAT activity, which may be a novel predictor for sBAT activity in healthy BAT-positive adults. Highlights A higher adiponectin concentration at baseline was associated with higher cold-induced supraclavicular BAT PET SUV mean and IRT Tscv max, and lower MR supraclavicular FF. Adiponectin levels maybe a novel predictor for cold-induced sBAT activity.


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 277-OR ◽  
Author(s):  
FARNAZ SHAMSI ◽  
TIAN LIAN HUANG ◽  
YU-HUA TSENG

Metabolism ◽  
2014 ◽  
Vol 63 (3) ◽  
pp. 312-317 ◽  
Author(s):  
Elayne Hondares ◽  
José M. Gallego-Escuredo ◽  
Pavel Flachs ◽  
Andrea Frontini ◽  
Ruben Cereijo ◽  
...  

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