scholarly journals Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients

2014 ◽  
Vol 15 (10) ◽  
pp. 907-914 ◽  
Author(s):  
Liang Liu ◽  
Bei-ni Liu ◽  
Shuo Chen ◽  
Miao Wang ◽  
Yang Liu ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Low Grade ◽  
Cardiovascular Dysfunction ◽  
Irritable Bowel ◽  
Low Grade Inflammation ◽  
Somatic Hypersensitivity

scholarly journals New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond

2017 ◽  
Vol 23 (36) ◽  
pp. 6593-6627 ◽  
Author(s):  
Emanuele Sinagra ◽  
Gaetano Cristian Morreale ◽  
Ghazaleh Mohammadian ◽  
Giorgio Fusco ◽  
Valentina Guarnotta ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Low Grade ◽  
Neuroendocrine Axis ◽  
Irritable Bowel ◽  
Low Grade Inflammation

Evidence from comparative genomic analyses indicating that Lactobacillus-mediated irritable bowel syndrome alleviation is mediated by the conjugated linoleic acid synthesis

2021 ◽  
Author(s):  
Yang Liu ◽  
Wei Xiao ◽  
Leilei Yu ◽  
Fengwei Tian ◽  
Gang Wang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Linoleic Acid ◽  
Gut Microbiota ◽  
Acid Synthesis ◽  
Comparative Genomic ◽  
Low Grade ◽  
Genomic Analyses ◽  
Irritable Bowel ◽  
Low Grade Inflammation ◽  
Gut Microbiota Dysbiosis

Irritable bowel syndrome (IBS) is a chronic intestinal disorder accompanied by low-grade inflammation, visceral hypersensitivity, and gut microbiota dysbiosis. Several studies have indicated that Lactobacillus supplementation can help to alleviate...

scholarly journals Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Song Jizhong ◽  
Wang Qiaomin ◽  
Wang Chao ◽  
Li Yanqing
Keyword(s):  
Gene Expression ◽  
Irritable Bowel Syndrome ◽  
Inflammatory Response ◽  
Psychiatric Symptoms ◽  
Corticotropin Releasing Factor ◽  
Low Grade ◽  
Lower Grade ◽  
Toll Like Receptor ◽  
Irritable Bowel ◽  
Low Grade Inflammation

The mechanism of low-grade inflammation in irritable bowel syndrome (IBS) is unclear; our research concentrates on the involvement of the corticotropin-releasing factor (CRF) and Toll-like receptor (TLR) gene expression in the process of low-grade inflammation in IBS patients with depression. This study suggests more IBS patients are presenting with the states of depression and anxiety. IBS patients with depression have shown a lower grade inflammatory response and an imbalance of the inflammatory response. CRF1, CRF2, TLR2, and TLR4 in IBS patients with depression are significantly higher than those without depression and controls. Thus, activation of the CRF-TLR associated pathways produces an inflammatory reaction, which can concurrently affect the digestive tract and the CNS and induce the corresponding digestive and psychiatric symptoms.

scholarly journals Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?

2016 ◽  
Vol 22 (46) ◽  
pp. 10198 ◽  
Author(s):  
Anna Chiara Piscaglia ◽  
Lucrezia Laterza ◽  
Valentina Cesario ◽  
Viviana Gerardi ◽  
Rosario Landi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Lymphoid Hyperplasia ◽  
Low Grade ◽  
Nodular Lymphoid Hyperplasia ◽  
Irritable Bowel ◽  
Low Grade Inflammation

scholarly journals Simmering Innards: Does Irritable Bowl Syndrome Have an Immunological Basis?

2004 ◽  
Vol 18 (10) ◽  
pp. 601-603 ◽  
Author(s):  
Christopher N Andrews ◽  
Eldon A Shaffer
Keyword(s):  
Spinal Cord ◽  
Irritable Bowel Syndrome ◽  
Low Grade ◽  
Irritable Bowel ◽  
Low Grade Inflammation ◽  
Brain And Spinal Cord ◽  
The Brain

Not so long ago, physicians construed the irritable bowel syndrome (IBS) as being a neurotic trait: it was all in the head. Today most clinicians believe that the main abnormality lies in the brain (and spinal cord), which reacts abnormally to stimuli from the gut. Recent studies are identifying a basis for these neural changes - low grade inflammation in the gut - which may play a key role in IBS.

scholarly journals The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe?

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Uday C. Ghoshal ◽  
Ratnakar Shukla ◽  
Ujjala Ghoshal ◽  
Kok-Ann Gwee ◽  
Siew C. Ng ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Pathogenic Bacteria ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Low Grade ◽  
Psychosomatic Disease ◽  
Irritable Bowel ◽  
Low Grade Inflammation ◽  
Qualitative Changes

Progress in the understanding of the pathophysiology of irritable bowel syndrome (IBS), once thought to be a purely psychosomatic disease, has advanced considerably and low-grade inflammation and changes in the gut microbiota now feature as potentially important. The human gut harbours a huge microbial ecosystem, which is equipped to perform a variety of functions such as digestion of food, metabolism of drugs, detoxification of toxic compounds, production of essential vitamins, prevention of attachment of pathogenic bacteria to the gut wall, and maintenance of homeostasis in the gastrointestinal tract. A subset of patients with IBS may have a quantitative increase in bacteria in the small bowel (small intestinal bacterial overgrowth). Qualitative changes in gut microbiota have also been associated with IBS. Targeting the gut microbiota using probiotics and antibiotics has emerged as a potentially effective approach to the treatment of this, hitherto enigmatic, functional bowel disorder. The gut microbiota in health, quantitative and qualitative microbiota changes, and therapeutic manipulations targeting the microbiota in patients with IBS are reviewed in this paper.

scholarly journals Morphological manifestations of irritable bowel syndrome

2021 ◽  
Vol 55 (2) ◽  
pp. 108-114
Author(s):  
Yu.M. Stepanov ◽  
I.Ya. Budzak ◽  
Yu.A. Gaidar
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Tight Junctions ◽  
Intestinal Mucosa ◽  
Morphological Changes ◽  
Low Grade ◽  
Intercellular Contacts ◽  
Irritable Bowel ◽  
Low Grade Inflammation

The article presents modern data on morphological changes in the intestinal mucosa in patients with irritable bowel syndrome. There were analyzed the studies of different years on the morphological manifestations of irritable bowel syndrome. It has been shown that this pathology has an unusual low-grade inflammation. Mast cells play an important role in these inflammatory disorders, they have an effect on motility disorders, visceral hypersensitivity and other pathogenetic factors of irritable bowel syndrome. Disorders of intercellular tight junctions in this category of patients were also analyzed. The role of proteins involved in intercellular contacts (occludin, claudin, ZO) has been characterized. An analysis of the studies investigating these disorders has been carried out. The article provides examples of the analysis of biopsies in patients with irritable bowel syndrome using various methods of their assessment.

Sign in / Sign up

Export Citation Format

Share Document