scholarly journals Cell-Cell Signaling Through NOTCH Regulates Human Embryonic Stem Cell Proliferation

Stem Cells ◽  
2008 ◽  
Vol 26 (3) ◽  
pp. 715-723 ◽  
Author(s):  
Victoria Fox ◽  
Paul J. Gokhale ◽  
James R. Walsh ◽  
Maryam Matin ◽  
Mark Jones ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cell Signaling ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Stem Cell Proliferation ◽  
Cell Cell

scholarly journals Role of CD133 in human embryonic stem cell proliferation and teratoma formation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hua Wang ◽  
Peng Gong ◽  
Jie Li ◽  
Yudong Fu ◽  
Zhongcheng Zhou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Stem Cell Proliferation ◽  
Teratoma Formation

scholarly journals PRMT5 is Required for Human Embryonic Stem Cell Proliferation But Not Pluripotency

2014 ◽  
Vol 10 (2) ◽  
pp. 230-239 ◽  
Author(s):  
Sofia Gkountela ◽  
Ziwei Li ◽  
Chee Jia Chin ◽  
Serena A. Lee ◽  
Amander T. Clark
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Stem Cell Proliferation

scholarly journals Effects of Oxidative Stress on Mouse Embryonic Stem Cell Proliferation, Apoptosis, Senescence, and Self-Renewal

2010 ◽  
Vol 19 (9) ◽  
pp. 1321-1331 ◽  
Author(s):  
Yan-Lin Guo ◽  
Samujjwal Chakraborty ◽  
Suja S. Rajan ◽  
Rouxing Wang ◽  
Faqing Huang
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation

scholarly journals 14-3-3σ Regulates β-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3β

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e40193 ◽  
Author(s):  
Tzu-Ching Chang ◽  
Chia-Chia Liu ◽  
En-Wei Hsing ◽  
Shu-Man Liang ◽  
Ya-Hui Chi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Stem Cell Proliferation ◽  
Gsk 3Β

scholarly journals Bidirectional Regulation of Mouse Embryonic Stem Cell Proliferation by Nicotine Is Mediated Through Wnt Signaling Pathway

Dose-Response ◽  
2017 ◽  
Vol 15 (4) ◽  
pp. 155932581773976 ◽  
Author(s):  
Qinglan Qu ◽  
Fengrong Zhang ◽  
Xiang Zhang ◽  
Weihong Yin
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Biologically Active ◽  
Stem Cell Proliferation ◽  
Bidirectional Regulation

Introduction: Nicotine is a key biologically active compound of cigarettes. Although nicotine is a risk factor for various health issues, it may also be beneficial when treated at moderate concentrations. Nicotine has been shown to bidirectionally regulate stem cell proliferation and differentiation depending on the doses applied. It is not clear whether or how nicotine regulates mouse embryonic stem cell (mESC) survival and proliferation. Methods: Mouse embryonic stem cells were cultured in the presence of 0.01, 0.1, 1, or 10 μM nicotine. The effects of nicotine on cell survival and proliferation were examined. The signaling pathway that mediated these effects was analyzed. Results: Cell viability was not affected by nicotine at all 4 concentrations examined. The proliferation of mESCs was promoted by 0.01 and 0.1 μM nicotine and suppressed by 1 and 10 μM. This dose-dependent regulation was mediated through the Wnt/β-catenin pathway. Modulation of Wnt/β-catenin activity either worsens or reverses the effects of nicotine. Conclusions: We have identified a bidirectional function of nicotine on mESC proliferation through regulation of the Wnt/β-catenin pathway and this is associated with different doses. This study suggests that concentration of nicotine is a crucial aspect for consideration when designing research or therapeutic strategies.

Sign in / Sign up

Export Citation Format

Share Document