scholarly journals Endocrine complications in long-term survivors of childhood cancers

2010 ◽  
Vol 17 (3) ◽  
pp. R141-R159 ◽  
Author(s):  
Wassim Chemaitilly ◽  
Charles A Sklar
Keyword(s):  
Childhood Cancer ◽  
Pubertal Development ◽  
Childhood Cancer Survivors ◽  
Special Focus ◽  
Mineral Density ◽  
Cancer Treatments ◽  
Gonadal Dysfunction ◽  
Endocrine Disturbances ◽  
Hypothalamic Pituitary Axis ◽  
Endocrine Complications

Endocrine disturbances are among the most frequently reported complications in childhood cancer survivors, affecting between 20 and 50% of individuals who survive into adulthood. Most endocrine complications are the result of prior cancer treatments, especially radiotherapy. The objective of the present review is to discuss the main endocrine complications observed in this population, including disorders of the hypothalamic–pituitary axis, disorders of pubertal development, thyroid dysfunction, gonadal dysfunction, decreased bone mineral density, obesity, and alterations in glucose metabolism with a special focus on recent findings reported from the Childhood Cancer Survivor Study.

scholarly journals DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments

2017 ◽  
Vol 176 (4) ◽  
pp. R183-R203 ◽  
Author(s):  
Wassim Chemaitilly ◽  
Laurie E Cohen
Keyword(s):  
Childhood Cancer ◽  
Late Effects ◽  
Systematic Approach ◽  
Childhood Cancer Survivors ◽  
Mineral Density ◽  
Cancer Treatments ◽  
Cancer History ◽  
Endocrine Disease ◽  
Improve Health ◽  
Endocrine Complications

Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-effects include impairments of the hypothalamus/pituitary, thyroid and gonads, as well as decreased bone mineral density and metabolic derangements leading to obesity and/or diabetes mellitus. A systematic approach where CCS are screened for endocrine late-effects based on their cancer history and treatment exposures may improve health outcomes by allowing the early diagnosis and treatment of these complications.

Endocrine Late Effects in Childhood Cancer Survivors

2018 ◽  
Vol 36 (21) ◽  
pp. 2153-2159 ◽  
Author(s):  
Wassim Chemaitilly ◽  
Laurie E. Cohen ◽  
Sogol Mostoufi-Moab ◽  
Briana C. Patterson ◽  
Jill H. Simmons ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors ◽  
Mineral Density ◽  
Pituitary Dysfunction ◽  
Previously Treated ◽  
Latency Interval ◽  
Improve Health ◽  
Endocrine Complications

Endocrine complications are highly prevalent in childhood cancer survivors. Approximately 50% of survivors will experience at least one hormonal disorder over the course of their lives. Endocrine complications often are observed in survivors previously treated with radiation to the head, neck, or pelvis. We provide an overview the most common endocrine late effects seen in survivors, including hypothalamic-pituitary dysfunction, primary thyroid dysfunction, obesity, diabetes mellitus, metabolic syndrome, and decreased bone mineral density. Primary gonadal injury is discussed elsewhere in this series. Given a variable latency interval, a systematic approach where individuals are periodically screened on the basis of their risk factors can help to improve health outcomes by prompt diagnosis and treatment of evolving endocrinopathies. These recommendations must be revised in the future given changes and improvements in cancer treatment over time.

Relationship between inhibin B, puberty, and secondary sex characteristics in childhood cancer survivors.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e22018-e22018
Author(s):  
Emel Cabi Unal ◽  
Gulsum KADIOGLU Simsek ◽  
Nurdan Tacyildiz ◽  
Handan Dincaslan ◽  
Gulsan Yavuz ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Hair Growth ◽  
Pubertal Development ◽  
Childhood Cancer Survivors ◽  
Sex Characteristics ◽  
Adult Type ◽  
Secondary Sex Characteristics ◽  
Gonadal Dysfunction ◽  
Menstrual History ◽  
Gonadal Toxicity

e22018 Background: Prognosis in childhood cancer improved with intensive tx regimens, improved survival,concerns&issues related to QOL become crucial point of interest. Methods: Gonadal functions were studied in 33M,22F survivors of childhood cancers treated w gonadotoxic chemotherapy,with HL,NHL, ALL,Osteosarcoma,Rhabdomyosarcoma. All event-free survivors for > 1year, postpubertal, > 15 years of age at the time of study, 8 pts received abdominal RT,9 pts had prophylactic cranial RT. Patients answered a questionnaire concerning sexual functions,underwent a comprehensive physical examination, clinical evaluation of pubertal development, secondary sex characteristics,menstrual history, measurement of FSH, LH,sex steroids, inhibinB, compared w age-matched controls. Results: All patients had normal pubertal development for age,Females showed no significant differences in secondary sex characteristics, than controls &the progression of puberty, adult-type hair growth in males were significantly late (P:0.002) than controls, low levels of testosterone were found in all.Pubertal development normal in female patients, w elevated FSH than control.(P:0.025)FSH levels in males didn't differ,inhibinB levels were significantly lower than control.(P:0.022).We couldn't demonstrate significant association with age at dx,time elapsed after tx,dx type,gonadotoxic agent.. Conclusions: Our study showed tx of childhood cancer could lead to gonadal toxicity.Our study investigating relationship between puberty,secondary sex characteristics,inhibinB in early postpubertal stage. Findings suggest that, even in the presence of gonadal toxicity, in females, secondary sex characteristics&puberty weren't affected.Inhibin B as a marker for gonadal toxicity is not superior to FSH. In fact that, we found a decrease in InhibinB as the only marker of gonadal dysfunction in males.With normal pubertal development &FSH levels in postpubertal males,low detection of inhibinB can be used as an early,sensitive marker for gonadal toxicity.Late adult-type hair growth with low testosterone demonstrating chemotherapy-induced testicular damage. Clinical trial information: BAP-2734.

Early endocrine complications in childhood cancer survivors

2016 ◽  
Vol 147 (8) ◽  
pp. 329-333
Author(s):  
Cristina Sánchez González ◽  
Mónica Andrades Toledo ◽  
Álvaro Cárdeno Morales ◽  
Ignacio Gutiérrez Carrasco ◽  
Gema Lucía Ramírez Villar ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Endocrine Complications

scholarly journals The long shadow of childhood cancer: A qualitative study on insurance hardship among survivors of childhood cancer

2020 ◽  
Author(s):  
Manya J Hendriks ◽  
Erika Harju ◽  
Katharina Roser ◽  
Marcello Ienca ◽  
Gisela Michel
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Social Insurance ◽  
Qualitative Content Analysis ◽  
Psychosocial Health ◽  
Childhood Cancer Survivors ◽  
Special Focus ◽  
Structured Interviews ◽  
Cancer History

Abstract Background The long-term consequences of childhood cancer have received increasing attention due to the growing number of survivors over the past decades. However, insurance hardships of survivors and their families are mostly unknown. This study explored qualitatively, in a sample of childhood cancer survivors (CCS), (i) the experiences and needs of CCS living in Switzerland with a special focus on hardships related to insurance; and (ii) the views of insurance and law experts with experience on childhood cancer. Methods Semi-structured interviews were conducted with 28 childhood cancer survivors and 3 experts (one legal expert, two insurance experts). Data was analysed using qualitative content analysis. Results Three key themes emerged from the interviews with the CCS: 1) experiences with insurance, 2) perception of discrimination, and 3) needs and barriers for support. The interviewed experts provided further detailed clarification of CCS’ concerns. Our findings indicated that some CCS can move past their cancer history, while others continue to face hardships. CCS reported confusion about the opportunities and services within the social security system and most relied on their personal contacts for guidance. Finally, CCS expressed a strong need for socio-economic and legal support for social insurance questions, especially related to disability insurance. Conclusions With the growing population of CCS, it is essential to further assess the interplay between medical and psychosocial health and socio-economic hardship. Supportive psychosocial services should aim to ameliorate insurance hardships. Better understanding of the relationship between childhood cancer and insurance hardships during survivorship will inform efforts to improve long-term financial security and health outcomes for survivors. We call for the public, lawmakers, researchers, insurers, and patient organizations to come together and discuss future perspectives to avoid the risk of discrimination for cancer survivors.

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