INCREASE IN PLASMA GROWTH HORMONE CONCENTRATION IN MAN AFTER INFUSION OF ADRENALINE-PROPRANOLOL

1970 ◽  
Vol 47 (1) ◽  
pp. 95-100 ◽  
Author(s):  
F. MASSARA ◽  
E. STRUMIA
Keyword(s):  
Growth Hormone ◽  
Healthy Volunteers ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Hormone Concentration ◽  
Nacl Solution ◽  
Plasma Growth Hormone ◽  
Growth Hormone Concentration ◽  
Wide Range

SUMMARY Plasma human growth hormone (HGH) concentrations were compared during four tests in which 0·9% NaCl solution only, propranolol, adrenaline or propranolol plus adrenaline were infused into six healthy volunteers. In five subjects, HGH levels during the infusion of saline, propranolol or adrenaline showed no significant increase and were virtually identical. During the test with propranolol plus adrenaline, however, there was an increase after adrenaline in spite of concomitant hyperglycaemia. The sixth volunteer showed a wide range of apparently spontaneous and irregular variations in HGH values throughout each of the four tests. These findings support the view that α-receptors stimulate and β-receptors depress HGH secretion, and show that adrenergically stimulated HGH secretion in man is not inhibited by hyperglycaemia.

EFFECT OF LIMB ISCHAEMIA AND SCALDING ON THE CONCENTRATIONS OF GROWTH HORMONE AND CORTICOSTERONE IN RAT PLASMA

1977 ◽  
Vol 73 (2) ◽  
pp. 347-353 ◽  
Author(s):  
R. N. BARTON
Keyword(s):  
Growth Hormone ◽  
Plasma Corticosterone ◽  
Rat Plasma ◽  
Limb Ischaemia ◽  
Hormone Concentration ◽  
Plasma Growth Hormone ◽  
Corticosterone Concentration ◽  
Growth Hormone Concentration ◽  
Wide Range ◽  
The Difference

SUMMARY In post-absorptive rats in a 20 °C environment, bilateral hind-limb ischaemia decreased the plasma growth hormone concentration below the very wide range found in control rats. Injection of sodium pentobarbitone increased the concentration in both control and injured rats but did not eliminate the difference between them. A 20% dorsal scald also decreased the variability of plasma growth hormone concentration but did not reduce it below the normal range. Thus growth hormone is probably not responsible for the insulin resistance seen in the severely injured rat. The plasma corticosterone concentration markedly increased after both injuries but was not altered by pentobarbitone.

Isotopic and nonisotopic assays for measuring somatotropin compared: re-evaluation of cutoff value in provocative tests

1991 ◽  
Vol 37 (2) ◽  
pp. 273-276 ◽  
Author(s):  
Gluseppe Banfi ◽  
Marcello Marinelli ◽  
Ermlnla Casari ◽  
Michelangelo Murone ◽  
Plerangel Bonini
Keyword(s):  
Growth Hormone ◽  
Monoclonal Antibodies ◽  
Human Growth Hormone ◽  
Reference Values ◽  
Polyclonal Antibodies ◽  
Human Growth ◽  
Complete Agreement ◽  
Cutoff Value ◽  
Short Children ◽  
Wide Range

Abstract Measurement of human growth hormone (hGH; somatotropin) concentrations in serum after provocative tests is crucial for diagnosing deficiencies in production of this hormone. Serum hGH can be measured by various immunoassays, isotopic and nonisotopic, with monoclonal or polyclonal antibodies: a cutoff value of 10 micrograms/L after provocative testing is usually used to distinguish normal from hGH-deficient children. Previous studies demonstrated discrepancies in hGH measurement by different radioisotopic immunoassays. Here we evaluated the responses of six different commercial assays, radioisotopic and nonisotopic, with monoclonal or polyclonal antibodies in a series of 16 provocative tests (stimulation with clonidine) in short children. A wide range of discrepant values was obtained with the different kits. A cutoff of 10 micrograms/L produced discordance of diagnosis among assays for two children, whereas complete agreement was reached for a cutoff value of 7 micrograms/L. Parallelism tests performed with hGH international standard, pure recombinant hGH, and a serum with high hGH content suggest that heterogeneity of the antibodies used by the manufacturers, even among monoclonal antibodies, is the main source of discordant results. Cutoff values and reference values must be established separately for each method proposed for routine use.

scholarly journals Plasma growth hormone concentration in corticosteroid-treated children

1968 ◽  
Vol 47 (3) ◽  
pp. 427-435 ◽  
Author(s):  
Helen G. Morris ◽  
Jacqueline R. Jorgensen ◽  
Shirley A. Jenkins
Keyword(s):  
Growth Hormone ◽  
Hormone Concentration ◽  
Plasma Growth Hormone ◽  
Growth Hormone Concentration
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