Secretion of inhibin A and inhibin B throughout pregnancy and the early postpartum period in chimpanzees

Plasma concentrations of inhibin A and inhibin B during pregnancy and early lactation in chimpanzees were determined by enzyme-linked immunosorbent assay (ELISA). Plasma samples were taken from five pregnant chimpanzees at 6-9, 10, 20 and 25 weeks of pregnancy, and following parturition. Throughout pregnancy and the early postpartum period, circulating inhibin A and inhibin B concentrations remained low, at similar levels to those during the normal menstrual cycle in chimpanzees. Concentrations of inhibin A in the placental homogenate were high enough to be measured by the ELISA and by bioassay, whereas circulating inhibin bioactivities in late pregnancy were too low to be measured. Plasma concentrations of FSH remained low with no significant changes throughout pregnancy and the postpartum period. Plasma concentrations of oestradiol-17beta and progesterone at 25 weeks of pregnancy were much higher than normal menstrual cycle levels. It was concluded that in chimpanzees the levels of circulating inhibin A and inhibin B remained low throughout pregnancy and the early postpartum period, and that the concentrations of bioactive dimeric inhibin did not increase towards the end of pregnancy. The suppression of circulating FSH levels during pregnancy is suggested to be controlled by steroid hormones that increased significantly in late pregnancy, and the present findings further suggest that the secretory pattern and role of inhibin during pregnancy in chimpanzees may be different from that in human and other primates.

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Secretion of Inhibin A and Inhibin B During Pregnancy and Early Postpartum Period in Japanese Monkeys

Endocrine ◽

10.1385/endo:18:1:21 ◽

2002 ◽

Vol 18 (1) ◽

pp. 21-26 ◽

Cited By ~ 3

Author(s):

Chihiro Kojima ◽

Masahiro Kondo ◽

WanZhu Jin ◽

Keiko Shimizu ◽

Mariko Itoh ◽

...

Keyword(s):

Postpartum Period ◽

Inhibin B ◽

Inhibin A ◽

Early Postpartum Period ◽

Japanese Monkeys ◽

Early Postpartum

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Hemostatic profile during late pregnancy and early postpartum period in mares

Theriogenology ◽

10.1016/j.theriogenology.2013.12.003 ◽

2014 ◽

Vol 81 (4) ◽

pp. 639-643 ◽

Cited By ~ 9

Author(s):

M. Bazzano ◽

C. Giannetto ◽

F. Fazio ◽

S. Marafioti ◽

E. Giudice ◽

...

Keyword(s):

Postpartum Period ◽

Late Pregnancy ◽

Early Postpartum Period ◽

Early Postpartum

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Secretion of inhibin A, inhibin B and inhibin pro-alphaC during the oestrous cycle of the golden hamster (Mesocricetus auratus)

Journal of Endocrinology ◽

10.1677/joe.0.1620451 ◽

1999 ◽

Vol 162 (3) ◽

pp. 451-456 ◽

Cited By ~ 11

Author(s):

K Ohshima ◽

H Kishi ◽

M Itoh ◽

G Watanabe ◽

K Arai ◽

...

Keyword(s):

Golden Hamster ◽

Plasma Concentrations ◽

Follicular Development ◽

Early Morning ◽

Oestrous Cycle ◽

Inhibin B ◽

Enzyme Linked Immunosorbent Assay ◽

Inhibin A ◽

Negative Relationships ◽

Plasma Oestradiol

Plasma concentrations of inhibin pro-alphaC, inhibin A and inhibin B were determined by enzyme-linked immunosorbent assay at 6 h intervals throughout the 4-day oestrous cycle of the golden hamster. Plasma concentrations of follicle-stimulating hormone (FSH) and oestradiol-17beta were also measured by radioimmunoassay during the oestrous cycle. Plasma concentrations of inhibin A increased from the early morning of day 1 (day 1=day of ovulation) and reached plateau levels at 0500 h on day 2. An abrupt increase in plasma concentrations of inhibin A was found at 1700 h on day 4, when the preovulatory FSH surge was observed. An increase in plasma concentrations of inhibin B occurred on day 1 and reached plateau levels at 1700 h on day 1. The levels remained elevated until 0500 h on day 4 and declined gradually by 2300 h on day 4. Plasma concentrations of inhibin pro-alphaC gradually increased with some fluctuation from day 1 to 1700 h on day 4 and then declined. Significant negative relationships were noted between plasma FSH and both dimeric forms of inhibin from day 1 to day 3. Significant positive relationships were found between plasma oestradiol-17beta and inhibin A or inhibin pro-alphaC throughout the oestrous cycle. In contrast, no significant relationship was found between plasma oestradiol-17beta and inhibin B. These findings suggest that both dimeric forms of inhibin play a role in the regulation of FSH secretion during follicular development. These findings also suggest that inhibin pro-alphaC could be secreted primarily by large follicles, and early atretic follicles could also be responsible for inhibin pro-alphaC secretion. On the other hand, the secretory pattern of dimeric inhibins might shift from inhibin B to inhibin A with follicular development.

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Serum levels of mitochondrial uncoupling protein 1, leptin, and lipids during late pregnancy and the early postpartum period in mares

Theriogenology ◽

10.1016/j.theriogenology.2016.04.005 ◽

2016 ◽

Vol 86 (5) ◽

pp. 1156-1164 ◽

Cited By ~ 7

Author(s):

F. Arfuso ◽

C. Giannetto ◽

M. Rizzo ◽

F. Fazio ◽

E. Giudice ◽

...

Keyword(s):

Postpartum Period ◽

Uncoupling Protein ◽

Late Pregnancy ◽

Serum Levels ◽

Uncoupling Protein 1 ◽

Mitochondrial Uncoupling ◽

Mitochondrial Uncoupling Protein ◽

Early Postpartum Period ◽

Early Postpartum

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Brain somatostatinergic system at late pregnancy, parturition and the early postpartum period in the rat

Regulatory Peptides ◽

10.1016/0167-0115(93)90164-4 ◽

1993 ◽

Vol 48 (3) ◽

pp. 355-363 ◽

Cited By ~ 3

Author(s):

Vicente Barrios ◽

Lillian Puebla ◽

Maria Nelly Rodriguez-Sanchez ◽

Eduardo Arilla

Keyword(s):

Postpartum Period ◽

Late Pregnancy ◽

Early Postpartum Period ◽

Early Postpartum

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Cerebellopontine angle meningioma diagnosed based on symptoms of trigeminal neuralgia in late pregnancy and showing spontaneous reduction in the early postpartum period: A case report

Neurology and Clinical Neuroscience ◽

10.1111/ncn3.12125 ◽

2017 ◽

Vol 5 (4) ◽

pp. 121-123

Author(s):

Yusuke Morinaga ◽

Haruaki Yamamoto ◽

Misato Kawaguchi ◽

Junya Asato ◽

Hayatsura Hanada ◽

...

Keyword(s):

Case Report ◽

Trigeminal Neuralgia ◽

Postpartum Period ◽

Cerebellopontine Angle ◽

Late Pregnancy ◽

Spontaneous Reduction ◽

Early Postpartum Period ◽

Early Postpartum

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Feature Article: Maternal cardiac messenger RNA expression of extracellular matrix proteins in mice during pregnancy and the postpartum period

Experimental Biology and Medicine ◽

10.1177/1535370218818457 ◽

2018 ◽

Vol 243 (15-16) ◽

pp. 1220-1232 ◽

Cited By ~ 1

Author(s):

Megan E Parrott ◽

Esam Aljrbi ◽

Diane L Biederman ◽

Ryan N Montalvo ◽

Jeremy L Barth ◽

...

Keyword(s):

Extracellular Matrix ◽

Left Ventricle ◽

Postpartum Period ◽

Matrix Protein ◽

Late Pregnancy ◽

Extracellular Matrix Protein ◽

Internal Diameter ◽

Mrna Levels ◽

Early Postpartum Period ◽

Early Postpartum

Pregnancy creates a condition of cardiac volume overload which leads to physiological eccentric hypertrophy of the heart that is reversed in the postpartum period. Pathological cardiac changes in non-pregnant animals are associated with extracellular matrix remodeling. Based on preliminary microarray findings in the hearts of non-pregnant, pregnant, and postpartum mice, we hypothesized that changes in the expression of extracellular matrix protein genes would accompany functional changes in the heart that occur with reproductive status. Adult left ventricle parameters were evaluated by echocardiography in C57BL/6 mice at diestrous (virgin), and at pregnancy days (eds) 10, 12, and 18/19, and at postpartum days (ppds) 1.5 and 7. Twenty-one left ventricle mRNAs were evaluated including genes for tissue inhibitor of metalloproteinases (Timps), several matrix metallopeptidases (Mmps), collagens (Cols), proteoglycans, and enzymes involved in matrix remodeling at similar days except ed10. Compared to virgin mice, left ventricle internal diameter during diastole and end diastolic volumes significantly increased at ed12, ed18/19, ppd1.5, and ppd7. Left ventricle internal diameter during systole was increased at ed18/19 and ppd1.5, and end systolic volume was increased at ed18/19 compared to virgin mice. Timp1 mRNA levels were higher in late pregnancy and the early postpartum period, and Timp2-4 mRNAs levels were lower at one or both postpartum days compared to specific earlier time points. Mmp3 mRNA levels were higher during late pregnancy and postpartum than earlier in pregnancy. Mmp13 mRNA level was lower at ppd1.5 than late pregnancy, and Mmp15 mRNA level was lowest at ppd7 compared to all other time points. Col1a1 and Col3a1 increased with pregnancy and stayed elevated through ppd7. Col8a1 mRNA was increased on both postpartum days compared to late pregnancy. Our results indicate that late pregnancy and the first week of the postpartum period are an active time for altered expression of extracellular matrix protein genes. Impact statement This study provides the first comprehensive analysis of extracellular matrix protein (ECM) gene expression combined with echocardiographic analyses of heart functional parameters in the murine heart during pregnancy and the early postpartum period. Our findings show regulation of all Timp, selected Mmps, and Col1a1, Col3a1, and Col8a1 mRNA levels with reproductive status, with the greatest number of significant changes occurring in the early postpartum period. Left ventricle cardiac diastolic parameters were the first to change during pregnancy and remained elevated postpartum, whereas systolic parameters were increased in late pregnancy and began to recover during the first week postpartum. These novel findings indicate that although some ECM genes are elevated during late pregnancy, that the postpartum period is a time of robust altered ECM gene expression. These studies provide a basis for examining ECM proteins and their activities in the normal pregnant and postpartum heart and in models of postpartum cardiomyopathy.

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