Predictors Associated with the Maintenance of Normal Thyroid Function after Unilateral Total Thyroidectomy in Patients with Papillary Thyroid Microcarcinoma

2019 ◽  
Vol 19 (3) ◽  
pp. 51
Author(s):  
Jihyeong Kim ◽  
Ha Kyoung Park ◽  
Taekwun Ha
Keyword(s):  
Total Thyroidectomy ◽  
Thyroid Function ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Normal Thyroid ◽  
Thyroid Microcarcinoma ◽  
Normal Thyroid Function

scholarly journals Gene Expression Profiles of Papillary Thyroid Microcarcinoma

2017 ◽  
Vol 102 (1-2) ◽  
pp. 39-46 ◽  
Author(s):  
Woo Young Kim ◽  
Jae Bok Lee ◽  
Seung Pil Jung ◽  
Hoon Yub Kim ◽  
Sang Uk Woo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Differentially Expressed Genes ◽  
Expression Profile ◽  
Expression Profiles ◽  
Differentially Expressed ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Normal Thyroid ◽  
Thyroid Microcarcinoma

The objective was to identify gene expression profile of papillary thyroid microcarcinoma. To help improve diagnosis of papillary thyroid microcarcinoma, we performed gene expression profiling and compared it to pair normal thyroid tissues. We performed microarray analysis with 6 papillary thyroid microcarcinoma and 6 pair normal thyroid tissues. Differentially expressed genes were selected using paired t test, linear models for microarray data, and significance analysis of microarrays. Real-time quantitative reverse transcription–polymerase chain reaction was used to validate the representative 10 genes (MET, TIMP1, QPCT, PROS1, LRP4, SDC4, CITED1, DPP4, LRRK2, RUNX2). We identified 91 differentially expressed genes (84 upregulated and 7 downregulated) in the gene expression profile and validated 10 genes of the profile. We identified a significant genetic difference between papillary thyroid microcarcinoma and normal tissue by 10 upregulated genes greater than 2-fold (P < 0.05).

scholarly journals A comparison of lobectomy and total thyroidectomy in patients with papillary thyroid microcarcinoma: a retrospective individual risk factor-matched cohort study

2017 ◽  
Vol 176 (4) ◽  
pp. 371-378 ◽  
Author(s):  
Hyemi Kwon ◽  
Min Ji Jeon ◽  
Won Gu Kim ◽  
Suyeon Park ◽  
Mijin Kim ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Microcarcinoma ◽  
Individual Risk ◽  
Matched Cohort ◽  
Papillary Thyroid ◽  
Individual Risk Factor ◽  
Matched Cohort Study ◽  
Thyroid Microcarcinoma

Objective Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in thyroid cancer in recent decades. We compared clinical outcomes and surgical complications of lobectomy and total thyroidectomy (TT) in PTMC patients. Design and methods In this retrospective individual risk factor-matched cohort study, 2031 patients with PTMC were initially included. Patients who underwent lobectomy or TT were one-to-one matched according to individual risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality and cervical lymph node (LN) metastasis. Results In total, 688 patients were assigned to each group. During the median 8.5 years of follow-up, 26 patients (3.8%) in the lobectomy group and 11 patients (1.6%) in the TT group had recurrences. The relative risk of recurrence was significantly less in the TT than that in the lobectomy group (hazard ratio (HR) 0.41; 95% confidence interval (CI) 0.21–0.81; P = 0.01). Most recurrences (84.6%) in the lobectomy group occurred in the contralateral lobe, and all patients were disease-free after completion of thyroidectomy. There were no significant differences in recurrence-free survival between the two groups after exclusion of contralateral lobe recurrences (HR, 2.75; 95% CI, 0.08–8.79; P = 0.08). There were significantly more patients with transient and permanent hypoparathyroidism in the TT than that in the lobectomy group (P < 0.001). Conclusions Lobectomy could be appropriate for most patients with PTMC when there is no evidence of extrathyroidal disease in the preoperative work-up. Preoperative and postoperative imaging studies are important for patients who undergo lobectomy for PTMC, because most recurrences are in the contralateral lobe.

Partial Thyroidectomy for Papillary Thyroid Microcarcinoma: Is Completion Total Thyroidectomy Indicated?

2015 ◽  
Vol 40 (3) ◽  
pp. 510-515 ◽  
Author(s):  
G. Donatini ◽  
M. Castagnet ◽  
T. Desurmont ◽  
N. Rudolph ◽  
D. Othman ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma ◽  
Partial Thyroidectomy

scholarly journals The Recovery of Thyroid Function in Low-Risk Papillary Thyroid Cancer After Lobectomy: A 3-Year Follow-Up Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Yi Dou ◽  
Yingji Chen ◽  
Daixing Hu ◽  
Xinliang Su
Keyword(s):  
Risk Factors ◽  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Low Risk ◽  
Hashimoto's Thyroiditis ◽  
First Year ◽  
Papillary Thyroid ◽  
Normal Thyroid ◽  
Normal Thyroid Function

PurposeManagement strategies after lobectomy for low-risk papillary thyroid carcinoma (PTC) are controversial. This study aimed to identify the proportion of patients among low-risk PTC patients who do not require hormone replacement therapy and to evaluate the risk factors for postoperative hypothyroidism after lobectomy.Patients and MethodsThe records of 190 PTC patients who underwent thyroid lobectomy from January 2017 to December 2018 were retrospectively reviewed. Clinicopathological characteristics and follow-up data were collected. Univariate and multivariate analyses were performed to identify the risk factors associated with postoperative hypothyroidism and the recovery of thyroid function.ResultsIn summary, 74.21% of patients (141/190) had normal thyroid function without levothyroxine supplementation, while 40.53% (77/190) developed temporary or permanent hypothyroidism. Multivariate analysis indicated that higher preoperative thyroid-stimulating hormone (TSH) levels (&gt;2.62 mIU/L), Hashimoto’s thyroiditis (HT), and right lobectomy were associated with hypothyroidism (all P&lt;0.05). The Area Under Curve (AUC) by logistic analysis was 0.829. Twenty-eight (28/77, 36.4%) patients recovered to the euthyroid state in the first year after surgery, and this recovery was significantly associated with preoperative TSH level. Forty-nine (49/77, 63.6%) patients developed persistent hypothyroidism. The thyroid function of most patients (11/28, 39.3%) recovered in the third month after surgery.ConclusionPatients with a lower level of preoperative TSH, with left lobectomy and without Hashimoto’s thyroiditis had a higher chance of normal thyroid function within the first year after lobectomy. The recovery of thyroid function was associated with the level of preoperative TSH.

scholarly journals Multifocal papillary thyroid microcarcinoma in the end stage of Hashimoto’s thyroiditis

2018 ◽  
Vol 146 (11-12) ◽  
pp. 672-676
Author(s):  
Bozidar Kovacevic ◽  
Snezana Kuzmic-Jankovic ◽  
Bosko Milev ◽  
Vesna Skuletic
Keyword(s):  
Total Thyroidectomy ◽  
Thyroid Tissue ◽  
Thyroid Volume ◽  
Final Diagnosis ◽  
Surrounding Tissue ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Disease Evolution ◽  
Thyroid Microcarcinoma ◽  
End Stage

Introduction. Frequent coexistence of papillary thyroid carcinoma (PTC) and Hashimoto?s thyroiditis (HT) indicates their immunological connection, with no consensus on the cause and effect of this relationship. The aim of this report is to present an unusual case of occurrence of multifocal papillary thyroid microcarcinoma in severe thyroid atrophy as a result of the end stage of HT and to analyze its clinical significance. Case outline. A 59-year-old female patient with a 14-year-long history of HT was admitted for the surgical treatment of a cytologically suspected PTC. During disease evolution, ultrasound controls were performed once a year and the findings showed a progressive decrease in thyroid volume. The nodule in the right lobe was detected for the first time in 2014. After a one-year follow-up, the nodule size was 7 mm. Fine needle aspiration biopsy was performed and was reported as ?suspicious for PTC.? The patient underwent total thyroidectomy. Intraoperatively, thyroid gland was indistinguishable from the surrounding tissue and histopathological intraoperative consultation was performed in order to confirm malignancy and thyroid tissue. After gross examination, all surgical specimens weighed less than 3 g. A final diagnosis of multifocal papillary thyroid microcarcinoma with bilateral presentation and extrathyroidal extension was made. Seventeen months after total thyroidectomy was performed, the patient was well, with no evidence of metastasis or recurrence of papillary carcinoma. Conclusion. In the circumstances of severe thyroid atrophy, papillary microcarcinoma with infiltrative growth can lead to early extrathyroid extension, and even to the infiltration of surrounding structures.

scholarly journals Bilateral versus unilateral papillary thyroid microcarcinoma: predictive factors and associated histopathological findings following total thyroidectomy

HORMONES ◽  
2013 ◽  
Vol 12 (4) ◽  
pp. 529-536 ◽  
Author(s):  
Theodore Karatzas ◽  
Ioannis Vasileiadis ◽  
George Charitoudis ◽  
Efthimios Karakostas ◽  
Sofia Tseleni-Balafouta ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Predictive Factors ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Histopathological Findings ◽  
Thyroid Microcarcinoma
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