Dry Eye Syndrome-Related Quality of Life in Glaucoma Patients

Purpose To verify the presence of dry eye syndrome (DES) in treated patients with glaucoma and to analyze DES's impact on the patients' quality of life (QOL) versus the control group. Methods In this observational cross-sectional study, 61 patients were enrolled at a clinical practice. Patients were divided into three groups by number of glaucoma drops instilled per day (G1=1 drop/day, G2=2 drops/day, G3=3 drops/day). A control group of 20 subjects was also selected (G0). All subjects were submitted to a complete ocular examination (including tear function and ocular surface status) and completed the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ), Glaucoma Symptom Scale (GSS) questionnaire, and Ocular Surface Disease Index (OSDI). DES was defined as presence of punctate keratitis and decreased break-up time. Statistical analysis was performed applying the Kruskal-Wallis analysis of variance and Mann-Whitney U tests (to compare median values between groups) as well as the χ2 and Fisher test (to verify significant differences). Results A total of 40% of G3 and 39% of G2 patients presented DES versus 11% of G1 and 5% of G0 (p=0.01). QOL was significantly influenced and altered (NEI-VFQ 25 total mean and GSS total mean and symptoms average: p=0.0085, p=0.006, and p=0.03, respectively). OSDI pointed out differences by group: 26% of G2 and 15% of G3 presented moderate OSDI and 15% of G3 and 8.7% of G2 severe OSDI (p>0.05). Conclusions Patients with topically treated glaucoma present DES more often than a similar control group (p=0.01). The presence of DES negatively influences the patient's QOL. The patients with glaucoma's ocular surface status should be evaluated regularly to ensure the timely detection and treatment of pathologic signs on the ocular surface.

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Stigma and quality of life for patients with facial dystonia: a cross-sectional study

10.21203/rs.3.rs-1184753/v1 ◽

2022 ◽

Author(s):

MING YI ◽

Jing LI ◽

Gang LIU ◽

Weixi ZHANG ◽

Ying WANG ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Short Form ◽

Cross Sectional Study ◽

Control Group ◽

Hamilton Depression Scale ◽

Sectional Study ◽

Cross Sectional ◽

Facial Dystonia

Abstract Background Facial appearance and expressions influence social interaction. However, few studies have reported on the stigma associated with spasms from facial dystonia. This study investigated the stigma and quality of life for these patients. Methods This cross-sectional study included 90 patients with facial dystonia (hemifacial spasm [HFS], blepharospasm [BSP], and blepharospasm-oromandibular dystonia [BOD]; 30 patients per group) and 30 individuals without dystonia (control group) from October 2019 to November 2020. All participants underwent stigma, quality of life, and mental health evaluations using seven questions related to stigma, the 36-item Short Form Health Survey, the 14-item version of the Hamilton Anxiety Scale (HAMA), and the 24-item version of the Hamilton Depression Scale. Results Nineteen patients (21.11%) felt stigmatized. Patients with BPS and HFS had more difficulty finding a job and were more susceptible to discrimination than healthy individuals. The role-physical and social function scores were significantly lower in the dystonia groups than in the control group. The vitality score of the BPS group and the mental health scores in the BPS and BOD groups were significantly less than those of the control group. The HAMA scores in the BPS and BOD groups were significantly higher than in the control group. Regression analysis demonstrated that the disease course influenced depression. Conclusion Enacted stigma from a negative public attitude may be the main factor triggering stigma in patients with facial dystonia, with detrimental effects on psychosocial outcomes, including social rights, quality of life, and mood.

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Profilo farmacologico clinico e farmacoeconomico di un gel oftalmico a base di carbomero 974P e PVA (Siccafluid®) nella terapia della cheratocongiuntivite secca

Farmeconomia Health economics and therapeutic pathways ◽

10.7175/fe.v6i3.834 ◽

2005 ◽

Vol 6 (3) ◽

pp. 185-196

Author(s):

Lorenzo Pradelli ◽

Letizia Vacchini

Keyword(s):

Quality Of Life ◽

Dry Eye ◽

Ocular Surface ◽

Tear Film ◽

Dry Eye Syndrome ◽

Lubricating Film ◽

Tear Production ◽

Ocular Discomfort ◽

Ophthalmic Solutions

BACKGROUND: The dry eye sindrome refers to a group of disorders of the tear film due to reduced tear production or excessive tear evaporation that is associated with symptoms of ocular discomfort and may cause disease of the ocular surface. Dry eye syndrome varies in severity, duration and etiology. The cornerstone of dry eye syndrome therapies includes the intraocular gel or ophthalmic solutions instillation, reaching correct artificial lubrication. Molecules that can produce a stable lubricating film are the carbomers. METHODS: In the first step of our work we reviewed the data from literature reporting about carbomers’ characteristics in respect to other lacrimal substitutes. Then, a pharmacoeconomical analysis has been performed on ophtalmic gels derived from carbomers 974P and PVA. RESULTS: Dry eye sindrome, if not adequately treated, determines a deterioration of the patient’s quality of life, other than high secondary costs. CONCLUSION: The high therapeutical index of carbomers 974P and PVA-based gels, in addition to the their limited cost (totally free for Sjögren patients in Italy), suggests that this product is characterized by one of the best benefits-to-costs ratios in the treatment of dry eye sindrome.

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The Functional State of Meibomian Glands and Tear Production in Pregnant Women

Ophthalmology in Russia ◽

10.18008/1816-5095-2018-2-151-159 ◽

2018 ◽

Vol 15 (2) ◽

pp. 151-159

Author(s):

V. N. Trubilin ◽

E. G. Poluninа ◽

D. V. Andzhelova ◽

Yu. V. Evstigneeva ◽

K. V. Chinenova

Keyword(s):

Quality Of Life ◽

Pregnant Women ◽

Functional State ◽

Dry Eye ◽

Ocular Surface ◽

Contact Lenses ◽

Dry Eye Syndrome ◽

Symptom Complex ◽

Meibomian Glands

Pregnant women are objects of special medical attention due to the fact that the new life — the life of her child — depends on the health and quality of life of the future mother. Pregnancy is a physiological load. It makes temporary changes in the functional state of all organs and systems, including the organ of vision. This study was aimed at identifying risk factors for the occurrence of disturbances in the tear-producing system — dysfunction of the Meibomian glands and/or dry eye syndrome (SSH), as well as to develop recommendations for compensating of disturbance. The study showed that physiological pregnancy does not affect to the condition of the ocular surface in case of absence of dry eye syndrome manifestations and Meibomian gland dysfunction before pregnancy. However, there is a predisposition for the development of the symptom complex of dry eye syndrome — a reliable decrease Schirmer test indicators of the test of in the group of pregnant women, it requires preventive control, — reduction in the mode of wearing contact lenses, which are a risk factor for the development of dry eye syndrome. It was determined that in vitro fertilization (IVF) affects to the condition of the ocular surface, namely, on the occurrence of dysfunction of Meibomian glands and dry eye syndrome, and is accompanied by corresponding complaints. There is a direct correlation between the duration of gestation, age indicators, the severity of complaints and their relationship to pregnancy. A direct was established, with a noticeable tightness of communication, between taking thyrotrophic drugs and complaints on dryness and discomfort. Therefore, special attention should be given to pregnant patients taking thyrotrophic medications and using contact lenses, since both of these factors provoke the development of the dry eye symptom complex. Patients with IVF pregnancy and accompanied by taking thyrotrophic drugs are recommended to limit the mode of wearing contact lenses, in case of complaints on dryness, discomfort, it is necessary to conduct therapeutic and prophylactic effects in the form of non-conserved tear-replacement therapy and eyelid hygiene. Timely diagnosis and subsequent prevention of Meibomian glands and dry eye syndrome in pregnant women will improve the quality of life of this patients group and prevent the development of complications related to this condition.

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Pain and quality of life of adolescents with primary dysmenorrhea in Tbilisi, Georgia, 2008. Cross sectional study

Revista Colombiana de Obstetricia y Ginecología ◽

10.18597/rcog.116 ◽

2013 ◽

Vol 64 (2) ◽

pp. 100-106

Author(s):

Tinatin Gagua ◽

Tkeshelashvili Besarion ◽

David Gagua

Keyword(s):

Quality Of Life ◽

Psychosocial Health ◽

Cross Sectional Study ◽

Control Group ◽

Primary Dysmenorrhea ◽

Sectional Study ◽

Cross Sectional ◽

Health Related Qol ◽

Health Related

Objective: The study aimed to measure the effect of primary dysmenorrhea on the quality of life of female adolescents living in Tbilisi, Georgia, and to compare Quality of Life (QoL) with healthy controls.Materials and methods: Cross-sectional study of 424 women aged 14-20, living in Tbilisi, Georgia, coming from academic and research institutions. The women were divided into those suffering dysmenorrhea (exposure group) and those without pain (control group). Reproductive history, demographic features, menstrual pattern, severity of dysmenorrhea and quality of life using the generic instrument EQ-5D, were measured. The Independent T student test was used for group comparison.Results: The group with dysmenorrhea (276) showed a lower Quality of Life score of 0.69 ± 0.20 vs. 0.94 ± 0.10 in the control group (p = 0.000); the Quality of Life VAS was also lower at 74.38 ± 17.83 vs. 87.02 ± 12.03 (p = 0.000). Of the subjetcs with primary dismenorrhea, 56.6% reported school absenteeism due to pain.Conclusion: Primary dysmenorrhea is a common problem in the adolescent population of Tbilisi, Georgia. The results of this study demonstrate that adolescents with primary dysmenorrhea in Georgia experience significantly lower physical and psychosocial health-related QoL than their healthy peers.

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Individuals with migraine have a different dry eye symptom profile than individuals without migraine

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-313471 ◽

2019 ◽

Vol 104 (2) ◽

pp. 260-264 ◽

Cited By ~ 4

Author(s):

Monika Farhangi ◽

Ryan J Diel ◽

Dawn C Buse ◽

Amy Michelle Huang ◽

Roy C Levitt ◽

...

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Cross Sectional Study ◽

Ocular Surface Disease Index ◽

Cross Sectional ◽

Symptom Profile ◽

Nerve Dysfunction ◽

The Difference ◽

Symptoms And Signs

BackgroundMany individuals with migraine report symptoms of dry eye (DE). However, it is not known whether DE profiles are similar between individuals with and without migraine. To bridge this gap, we evaluated symptoms and signs of DE, including symptoms suggestive of nerve dysfunction, in a large group of individuals with DE symptoms, and compared profiles between individuals with migraine and those without migraine or headache.MethodsProspective cross-sectional study of individuals with DE symptoms seen at the Miami VA.ResultsOf 250 individuals, 31 met International Classification of Headache Disorders criteria for migraine based on a validated screen. Individuals with migraine were significantly younger (57 vs 62 years) and more likely to be female (26% vs 6%) than controls. Individuals with migraine had more severe DE symptoms and ocular pain compared with controls (mean Ocular Surface Disease Index 53.93 ± 21.76 vs 36.30 ± 22.90, p=0.0001; mean Neuropathic Pain Symptom Inventory modified for the Eye 39.39 ± 23.33 vs 21.86 ± 20.17, p=0.0001). The difference in symptom profile occurred despite similar ocular surface parameters between the groups.ConclusionsIndividuals with migraine had a different DE symptom yet a similar DE sign profile when compared with controls without migraine. This suggests that DE symptoms in individuals with migraine may be driven by nerve dysfunction as opposed to ocular surface abnormalities.

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Self-stigma and quality of life in outpatients with depressive disorder – a cross-sectional study

European Psychiatry ◽

10.1016/j.eurpsy.2017.02.003 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S238-S238

Author(s):

M. Holubova ◽

J. Prasko ◽

M. Ociskova ◽

M. Marackova ◽

A. Grambal ◽

...

Keyword(s):

Quality Of Life ◽

Depressive Disorder ◽

Depressive Disorders ◽

Negative Impact ◽

Cross Sectional Study ◽

Control Group ◽

Healthy Controls ◽

Sectional Study ◽

Cross Sectional

BackgroundSelf-stigma is a maladaptive psychosocial phenomenon that may disturb many areas of patient's life and have the negative impact on their quality of life. The present study explored the association between self-stigma, quality of life, demographic data, and the severity of symptoms in patients with depressive disorder.MethodPatients, who met ICD-10 research criteria for depressive disorder, were enrolled in the cross-sectional study. All probands completed these measurements: the Quality of Life Satisfaction and Enjoyment Questionnaire (Q-LES-Q), the Internalised Stigma of Mental Illness Scale (ISMI), demographic questionnaire, and the severity of the disorder measured by objective and subjective Clinical Global Impression severity scales (CGI).ResultsEighty-one depressive patients (with persistent affective disorder – dysthymia, major depressive disorder or recurrent depressive disorder) and 43 healthy controls contributed to the study. Comparing with the healthy control group, there was a lower quality of life in patients with depression. The level of self-stigma correlated positively with total symptom severity score and negatively with the quality of life. Multiple regression analysis discovered that the overall rating of objective symptoms severity and self-stigma were significantly associated with the quality of life.ConclusionsPresent study suggests the lower quality of life in outpatients with depressive disorder in comparison with healthy controls, and the negative impact of self-stigma level on quality of life in patients suffering from depressive disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Impact of Fake Braces on Oral Health Related Quality of Life: A Web-Based Cross-Sectional Study

10.21203/rs.3.rs-15505/v1 ◽

2020 ◽

Author(s):

Zaki Hakami ◽

Hye Soo Chung ◽

Seham Moafa ◽

Hadia Nasser ◽

Hajar Sowadi ◽

...

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Cross Sectional Study ◽

Control Group ◽

Health Related Quality ◽

Sectional Study ◽

Cross Sectional ◽

Related Quality ◽

Health Related

Abstract Background Fake braces have become popular as fashionable appliances in some parts of the world, however, there is a scarcity of information about their effects on various aspects of quality of life. Therefore, our aim was to investigate the effects of fake braces on oral health related quality of life (OHRQoL).Methods A cross-sectional study was carried out with data collection from a Google form questionnaire distributed in Saudi Arabia via various forms of social media over a period of four months. OHRQoL was assessed using the validated Arabic version of the Oral Health Impact Profile-14 (OHIP-14) questionnaire. Fake braces group included respondents who had braces installed for fashion purposes only. Therapeutic braces group included subjects who were wearing braces to treat any malocclusion problems. Control group included participants who did not have any kind of braces. People who had previously completed orthodontic treatments were excluded from the study. The negative impacts were divided into seven domains and a total OHIP score was calculated. Statistical analyses and data illustration were performed with SPSS Statistics (v. 25).Results A total of 1167 people voluntarily participated in the study. More than 60% of the participants were in the control group while 30% had conventional braces for therapeutic reasons and less than 5% had fashion braces under investigation. Sociodemographic distributions varied among the groups and the majority of the subjects in fake braces group had education below the university level with family income of less than average. There were no significant group differences in total OHIP scores. Physical pain was the most frequently reported complaint by all subjects and was the highest in the therapeutic braces group. People with fake or therapeutic braces reported significantly higher functional limitation and physical disability than the control. Yet, fashion braces group reported significantly lower psychological discomfort and disability compared to the therapeutic braces or control groups.Conclusions The illustrated effects of fake braces on OHRQoL in this study suggests the need to study the role of social media and educate the public on the use of braces to minimize the negative effects experienced by individuals.

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Prevalence and pattern of dry eye symptoms among “okada” riders in Southwest Nigeria using the ocular surface disease index: A cross sectional study

Journal of Clinical Sciences ◽

10.4103/jcls.jcls_37_20 ◽

2021 ◽

Vol 18 (2) ◽

pp. 81

Author(s):

AdetunjiOlusesan Adenekan ◽

OlubankeTheodora Ilo ◽

AdegboyegaSunday Alabi ◽

OlufisayoTemitayo Aribaba ◽

FolasadeBolanle Akinsola

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Cross Sectional Study ◽

Disease Index ◽

Sectional Study ◽

Ocular Surface Disease Index ◽

Cross Sectional ◽

Southwest Nigeria ◽

Eye Symptoms ◽

Dry Eye Symptoms

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Modified ocular surface disease index as a screening criteria for dry eye syndrome presenting after successful dacryocystorhinostomy

PLoS ONE ◽

10.1371/journal.pone.0247168 ◽

2021 ◽

Vol 16 (2) ◽

pp. e0247168

Author(s):

Tae Seen Kang ◽

Jin Cho ◽

Jaeyoung Kim ◽

Jae Yun Sung ◽

Ju Mi Kim ◽

...

Keyword(s):

Diagnostic Criteria ◽

Dry Eye ◽

Ocular Surface ◽

Disease Index ◽

Dry Eye Syndrome ◽

Ocular Surface Disease ◽

Control Group ◽

Ocular Surface Disease Index ◽

Blurred Vision ◽

Screening Criteria

Objective To find preoperative screening criteria for dry eye syndrome (DES) that present after successful endoscopic dacryocystorhinostomy (EDCR). Methods We retrospectively analyzed medical records of 110 patients who underwent EDCR for nasolacrimal duct obstruction. DES diagnostic criteria were defined as tear break-up time (TBUT) less than 10 seconds, and ocular surface disease index (OSDI) score greater than 13 points. After EDCR, patients were divided into DES group and control group according to the DES diagnostic criteria. Preoperative OSDI score alone or in combination of preoperative TBUT and OSDI score were used to find screening criteria, which could discriminate the two groups preoperatively with a high positive predictive value (PPV). Criteria A was set same as the diagnostic criteria of DES, and Criteria B and C were set to improve PPV by increasing specificity while maintaining similar sensitivity to Criteria A. Results Thirty patients (27.3%) were diagnosed with DES after EDCR, while 80 patients (72.7%) were normal. In patients with DES, preoperative TBUT was not different (p = 0.851), but OSDI score was significantly higher (p<0.001). Criteria A showed a sensitivity of 73.3%, specificity of 55.0%, and PPV of 38.0%. Criteria B and C excluded preoperative TBUT, which had no difference between the two groups, and set screening criteria with preoperative OSDI score alone. Criteria B (preoperative OSDI score of 19.6 points or more) showed a sensitivity of 75.0%, specificity of 60.6%, PPV of 41.7% and AUC of 0.739 (p < 0.001). Criteria C was consisted of 5 out of 12 OSDI items that showed significant differences between the two groups; blurred vision, reading, working with a computer, low humidity, and air conditioning. Criteria C (preoperative 5-item OSDI score of 24.4 points or more) was a better predictability, with a sensitivity of 75.0%, specificity of 71.3%, PPV of 49.5%, and AUC of 0.804 (p < 0.001). The AUC of Criteria C was significantly higher than that of Criteria B (p = 0.0037). Conclusion DES occurred after successful EDCR in 27.3% of patients, and an OSDI questionnaire helped to screen DES. The predictability could improve using the modified OSDI score which showed noticeable difference in five OSDI items before and after EDCR.

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Foot health and quality of life in patients with rheumatoid arthritis: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2020-036903 ◽

2020 ◽

Vol 10 (5) ◽

pp. e036903 ◽

Cited By ~ 1

Author(s):

Andres Reinoso-Cobo ◽

Gabriel Gijon-Nogueron ◽

Rafael Caliz-Caliz ◽

Miguel Angel Ferrer-Gonzalez ◽

Maria Teresa Vallejo-Velazquez ◽

...

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

Cross Sectional Study ◽

Control Group ◽

Foot Pain ◽

Sectional Study ◽

Cross Sectional ◽

Foot Health ◽

Pain Disability

ObjectiveThe aim of this study is to identify foot health factors related to the quality of life in patients with rheumatoid arthritis (RA).SettingIn this cross-sectional study, a total of 293 subjects were analysed, 229 of whom were in the RA group and 64 in the control group. In the RA group, 173 patients were female, and 50 in the control group.ParticipantsPatients with foot pain and RA (according to the American College of Rheumatology/European League Against Rheumatism 2010 rheumatoid arthritis classification criteria) and with foot pain but no RA were recruited (Granada, Spain).InterventionTwo researchers independently interviewed the patients to obtain data for the study.Primary and secondary outcome measuresClinical data were obtained using the Short Form 12-Item questionnaire (quality of life) (primary outcome), Visual Analogue Scale for pain (VAS pain), the Manchester Foot Pain Disability Index (MFPDI) and the Foot Function Index (FFI). Anthropometric measurements were obtained using a foot measurement platform, the Foot Posture Index and the Manchester Scale of Hallux Valgus (secondary outcomes).ResultsOf the 293 subjects, 76.1% were female. Significant differences were observed between the RA and the control group (p<0.001) with regard to VAS pain (general, foot and hand), MFPDI and FFI. In terms of anthropometric measurements, significant differences were only recorded for midfoot and forefoot width (p=0.03). For the physical health component, multivariable linear regression with the parameters age, gender, VAS pain (general) and the presence of RA presented an R2 value of 48.8%, while for the mental health component the corresponding value was 5.6%.ConclusionMorphological and structural characteristics of the foot are not necessarily associated with pain, disability and loss of function. The presence of RA, a higher score on VAS pain (general), female gender and older age are all associated with the physical component of the quality of life of patients with RA.

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