SEARCH FOR RISK FACTORS OF REGIONAL METASTASIS OF DIFFERENTIATED THYROID CANCER

Diagnostic difficulties of regional metastases, especially lesion of the central neck, is the main problem with choosing the type of surgical intervention for patients with differentiated thyroid cancer diagnosis. The frequency of differentiated thyroid cancer regional metastasis to the neck lymph nodes is about 60 %. This article includes the search and identification of risk factors of differentiated thyroid cancer regional metastases, as well as a review of the literature on this problem. We have analyzed the results of surgical treatment of patients with papillary thyroid cancer of Stage I–III (T1–4aN0–1bM0) who underwent surgical treatment at the St. Petersburg State Healthcare Institution «City Clinical Oncology Center» in 2018–2019. As a result of the study, the data revealed a relationship between regional metastases and intrathyroid vascular invasion of the primary tumor (p < 0.05), while multifocality, extrathyroid extension and the incidence of BRAF mutation have not demonstrated this correlation (p > 0.05). After the surgical treatment we should focus on the presence of vascular invasion and, if it is detected, perform final thyroidectomy and central lymph node dissection with subsequent radioiodine therapy.

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Our Understanding of Well-differentiated Thyroid Cancer

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1308 ◽

2017 ◽

Vol 8 (2) ◽

pp. 64-70

Author(s):

Christopher Thompson ◽

Iain J Nixon

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Differentiated Thyroid Cancer ◽

Current Understanding ◽

Prognostic Indicators ◽

Special Issue ◽

Well Differentiated ◽

Head Neck

ABSTRACT Through significant contributions to our understanding of risk factors, prognostic indicators and management of well-differentiated thyroid cancer (WDTC), Prof Jatin Shah has contributed much to the field of thyroid cancer in recent times. Many of the guidelines used in WDTC management today are a testament to his less-aggressive, dedicated and individualised approach. This article seeks to both review the current understanding of WDTC and to outline these contributions in a special issue dedicated to the career of Prof Shah. How to cite this article Thompson C, Nixon IJ. Our Understanding of Well-differentiated Thyroid Cancer. Int J Head Neck Surg 2017;8(2):64-70.

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Clinicopathologic risk factors of radioactive iodine therapy based on response assessment in patients with differentiated thyroid cancer: a multicenter retrospective cohort study

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-019-04634-8 ◽

2019 ◽

Vol 47 (3) ◽

pp. 561-571 ◽

Cited By ~ 1

Author(s):

Seong Young Kwon ◽

◽

Sang-Woo Lee ◽

Eun Jung Kong ◽

Keunyoung Kim ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Thyroid Cancer ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Differentiated Thyroid Cancer ◽

Radioactive Iodine ◽

Response Assessment ◽

Radioactive Iodine Therapy

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Pituitary neuroendocrine tumors and differentiated thyroid cancer: do metabolic and inflammatory risk factors play roles?

Journal of Endocrinological Investigation ◽

10.1007/s40618-020-01357-8 ◽

2020 ◽

Author(s):

G. Cortês Nascimento ◽

A. G. P. de Araujo Cortês Nascimento ◽

C. de Maria Ribeiro Veiga Parente ◽

V. P. Rodrigues ◽

R. S. de Sousa Azulay ◽

...

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Neuroendocrine Tumors ◽

Differentiated Thyroid Cancer

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Risk Factors for Recurrence in Filipinos with Well-Differentiated Thyroid Cancer

Endocrinology and Metabolism ◽

10.3803/enm.2015.30.4.543 ◽

2015 ◽

Vol 30 (4) ◽

pp. 543 ◽

Cited By ~ 6

Author(s):

Tom Edward Ngo Lo ◽

Abigail Uy Canto ◽

Patricia Deanna D. Maningat

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Differentiated Thyroid Cancer ◽

Risk Factors For Recurrence ◽

Well Differentiated

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Symptomatic Primary Hyperparathyroidism as a Risk Factor for Differentiated Thyroid Cancer

Journal of Thyroid Research ◽

10.1155/2018/9461079 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Guadalupe Vargas-Ortega ◽

Lourdes Balcázar-Hernández ◽

Baldomero González-Virla ◽

Claudia Ramírez-Rentería ◽

Oriana Nieto-Guzmán ◽

...

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Primary Hyperparathyroidism ◽

Differentiated Thyroid Cancer ◽

Thyroid Nodules ◽

Common Disease ◽

Follicular Variant ◽

Biochemical Characteristics ◽

Oncocytic Variant ◽

Columnar Cells

Background. The primary hyperparathyroidism (PHPT) is a common disease for the endocrinologist. The concomitant thyroid disease and differentiated thyroid cancer (DTC) appear to be more frequent in patients with PHPT than in the general population. The aim of this study was to characterize patients with symptomatic PHPT with and without DTC and analyze frequency and risk factors.Methods. We consecutively studied patients with symptomatic PHPT diagnosed and treated at our center between 2013 and 2015. Patients with subclinical and syndromic forms of PHPT were excluded. Clinical and biochemical characteristics of patients with and without DTC were compared and risk factors were determined. All patients were studied with thyroid ultrasound and thyroid gammagraphy with TC-MIBI. Two expert surgeons performed all the surgical procedures.Results. In 59 patients included, we found 12 cases of PTC (20.3%). The final histopathological report of the PTC was 7 cases of follicular variant, 2 cases of oncocytic variant, 2 cases of classic variant, and 1 case of columnar cells variant of PTC. Patients with thyroid cancer were older than patients without thyroid cancer (62 ± 9.5 versus 52 ± 15.8, p = 0.03). Higher preoperative levels of iPTH were associated with PTC (p=0.03) [OR 5.16 (95% CI: 1.08-24.7)].Conclusion. PTC is frequent in patients with symptomatic PHPT. Thyroid nodules in patients with symptomatic PHPT must be studied before parathyroidectomy. In symptomatic PHPT, higher level concentration of parathormone (PTH) was associated with higher risk of DTC.

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