Illumination sensitivity analysis for the speck-based froth detection method using potash flotation machines

2021 ◽  
pp. 29-33
Author(s):  
S. A. Varlamova ◽  
A. V. Zatonsky ◽  
K. A. Fedoseeva
Keyword(s):  
Sensitivity Analysis ◽  
Detection Method ◽  
Flotation Machines

scholarly journals MicroRNA expression signatures of atrial fibrillation: The critical systematic review and bioinformatics analysis

2019 ◽  
Vol 245 (1) ◽  
pp. 42-53 ◽  
Author(s):  
Nan-Nan Shen ◽  
Chi Zhang ◽  
Zheng Li ◽  
Ling-Cong Kong ◽  
Xin-Hua Wang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Sensitivity Analysis ◽  
Mirna Expression ◽  
Bioinformatics Analysis ◽  
Detection Method ◽  
Expression Profiles ◽  
Differentially Expressed ◽  
Cochrane Library ◽  
Differentially Expressed Mirnas

Association between microRNA (miRNA) expression signatures and atrial fibrillation has been evaluated with inconsistent findings in different studies. This study aims to identify miRNAs that actually play vital role in pathophysiological process of atrial fibrillation and explore miRNA-targeted genes and the involved pathways. Relevant studies were retrieved from the electronic databases of Embase, Medline, and Cochrane Library to determine the miRNA expression profiles between atrial fibrillation subjects and non-atrial fibrillation controls. Robustness of results was assessed using sensitivity analysis. Subgroup analyses were performed based on species, miRNA detection method, sample source, and ethnicity. Quality assessment of studies was independently conducted according to QUADAS-2. Bioinformatics analysis was applied to explore the potential genes and pathways associated with atrial fibrillation, which were targeted by differentially expressed miRNAs. Form of pooled results was shown as log10 odds ratios (logORs) with 95% confidence intervals (CI), and random-effects model was used. In total, 40 articles involving 283 differentially expressed miRNAs were reported. And 51 significantly dysregulated miRNAs were identified in consistent direction, with 22 upregulated and 29 downregulated. Among above-mentioned miRNAs, miR-223-3p (logOR 6.473; P < 0.001) was the most upregulated, while miR-1-5p (logOR 7.290; P < 0.001) was the most downregulated. Subgroup analysis confirmed 53 significantly dysregulated miRNAs (21 upregulated and 32 downregulated) in cardiac tissue, with miRNA-1-5p and miRNA-223-3p being the most upregulated and downregulated miRNAs, respectively. Additionally, miR-328 and miR-1-5p were highly blood-specific, and miR-133 was animal-specific. In the detection method sub-groups, miRNA-29b and miRNA-223-3p were differentially expressed consistently. Four miRNAs, including miRNA-223-3p, miRNA-21, miRNA-328, and miRNA-1-5p, were consistently dysregulated in both Asian and non-Asian. Results of sensitivity analysis showed that 47 out of 51 (92.16%) miRNAs were dysregulated consistently. Totally, 51 consistently dysregulated miRNAs associated with atrial fibrillation were confirmed in this study. Five important miRNAs, including miR-29b, miR-328, miR-1-5p, miR-21, and miR-223-3p may act as potential biomarkers for atrial fibrillation. Impact statement Atrial fibrillation (AF) is considered as the most common arrhythmia, and it subsequently causes serious complications including thrombosis and heart failure that increase the social burden. The definite mechanisms underlying AF pathogenesis remain complicated and unclear. Many studies attempted to discover the transcriptomic changes using microarray technologies, and the present studies for this hot topic have assessed individual miRNAs profiles for AF. However, results of different articles are controversial and not each reported miRNA is actually associated with the pathogenesis of AF. The present systematic review and meta-analysis identified that 51 consistently dysregulated miRNAs were associated with AF. Of these miRNAs, five miRNAs (miRNA-1-5p, miRNA-328, miRNA-29b, miRNA-21, and miRNA-223-3p) may act as novel biomarkers for AF. The findings could offer a better description of the biological characteristics of miRNAs, meanwhile might serve as new target for the intervention and monitoring AF in future studies.

Research on Limited Bearing Capacity Detection Method of Large Erection Equipment Operation Site

2012 ◽  
Vol 170-173 ◽  
pp. 3274-3279
Author(s):  
Hong Jie Cheng ◽  
Zhi Bo Qian ◽  
Yuan Zhao ◽  
Chuan Qiang Yu
Keyword(s):  
Sensitivity Analysis ◽  
Bearing Capacity ◽  
Conceptual Design ◽  
Detection Method ◽  
Weapon System ◽  
Fast Reaction ◽  
Equipment Operation ◽  
Bearing Load ◽  
Reaction Capability ◽  
Launching Site

To enhance the survival capability and fast reaction capability of missile weapon system, the research on choosing launching site during the process of missile erection has been carried out. In this paper, the bearing load of launching site is analyzed in missile erecting process, and the equation of limiting bearing capacity is deduced according to K. Terzaghi suggesting equation. Combining with explicit reliability analyzing method, the sensitivity analysis of factors which influence the bearing capacity has been executed, and the detection method has been researched for partial factors which influence bearing capacity obviously. Finally, the general conceptual design of evaluating bearing capacity and choosing launching site have been provided based on blocking design thought.

Sensitivity analysis of the vestigial signal defence‐based civil GNSS spoofing detection method

2017 ◽  
Vol 11 (5) ◽  
pp. 861-872 ◽  
Author(s):  
Zhenjun Zhang ◽  
Xingqun Zhan ◽  
Shaojun Feng ◽  
Washington Yotto Ochieng
Keyword(s):  
Sensitivity Analysis ◽  
Detection Method ◽  
Spoofing Detection

Identification approach for bottleneck clusters in a job shop based on theory of constraints and sensitivity analysis

2015 ◽  
Vol 231 (6) ◽  
pp. 1091-1101 ◽  
Author(s):  
Qi Lei ◽  
Tong Li
Keyword(s):  
Sensitivity Analysis ◽  
Manufacturing Systems ◽  
Job Shop ◽  
Detection Method ◽  
Production Optimization ◽  
Production Performance ◽  
Bottleneck Detection ◽  
Index Matrix ◽  
Identification Approach ◽  
Bottleneck Machine

Manufacturing systems are constrained by one or more bottlenecks. Reducing bottlenecks improves the entire system. Finding bottlenecks, however, is a difficult task. In this study, a new bottleneck detection method based on theory of constrains and sensitivity analysis is presented to overcome the disadvantages of existing bottleneck identification methods for a job shop. First, a bottleneck index matrix is obtained by examining the sensitivity of system production performance to the capacity of each machine. Technique for order preference by similarity to ideal solution is then employed to calculate the comprehensive bottleneck index of each machine. Based on the calculation result, bottleneck machine clusters under different hierarchies are obtained through hierarchical cluster analysis. The designed identification approach, as a prior-to-run method, can identify bottleneck machine clusters under different hierarchies before the overall system circulation, thereby providing good guidance for subsequent production optimization. Finally, a set of job-shop scheduling problem benchmarks with different scales is selected for comparison between the proposed approach and existing approaches, such as, the shifting bottleneck detection method, the bottleneck detection method based on orthogonal experiment, and the bottleneck cluster identification method. By comparison, the proposed approach is proven to be credible and superior.

Solid-phase immunoelectron microscopy for rapid diagnosis of enteroviruses

1984 ◽  
Vol 42 ◽  
pp. 226-227 ◽  
Author(s):  
K. Pegg-Feige ◽  
F. W. Doane
Keyword(s):  
Electron Microscopy ◽  
Cell Culture ◽  
Immunoelectron Microscopy ◽  
Detection Method ◽  
Solid Phase ◽  
Protein A ◽  
Plant Viruses ◽  
Rapid Diagnosis ◽  
Virus Diagnosis ◽  
Antiviral Antibody

Immunoelectron microscopy (IEM) applied to rapid virus diagnosis offers a more sensitive detection method than direct electron microscopy (DEM), and can also be used to serotype viruses. One of several IEM techniques is that introduced by Derrick in 1972, in which antiviral antibody is attached to the support film of an EM specimen grid. Originally developed for plant viruses, it has recently been applied to several animal viruses, especially rotaviruses. We have investigated the use of this solid phase IEM technique (SPIEM) in detecting and identifying enteroviruses (in the form of crude cell culture isolates), and have compared it with a modified “SPIEM-SPA” method in which grids are coated with protein A from Staphylococcus aureus prior to exposure to antiserum.

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