scholarly journals Case of acute acquired toxoplasmosis treatment during pregnancy

2016 ◽  
Vol 21 (2) ◽  
pp. 99-102
Author(s):  
A. A Konchakova ◽  
Marina G. Avdeeva ◽  
M. I Kulbuzheva
Keyword(s):  
First Trimester ◽  
Neurological Status ◽  
Psychomotor Development ◽  
Second Trimester ◽  
The Status ◽  
First Trimester Of Pregnancy ◽  
Acute Toxoplasmosis ◽  
Acquired Toxoplasmosis ◽  
Monocytes And Lymphocytes ◽  
Status Of Women

There is reported an example of a clinical diagnosis and successful treatment of acute acquired toxoplasmosis, manifested in the first trimester of pregnancy. Implementation of specific antiparasitic therapy starting from the second trimester of pregnancy contributed both to the normalization of the status of women and prevention of congenital malformations of the fetus. Dynamic following up of the child showed stable positive neurological status, psychomotor development corresponded to age over 8 years. The increasing of cytochemical activity of monocytes and lymphocytes is a sensitive additional diagnostic test for acute toxoplasmosis in pregnant women.

95-OR: Plasma miRNAs Levels at First Trimester of Pregnancy Predict Insulin Sensitivity Estimated at the Second Trimester of Pregnancy

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 95-OR
Author(s):  
CÉCILIA LÉGARÉ ◽  
VÉRONIQUE DESGAGNÉ ◽  
FRÉDÉRIQUE WHITE ◽  
MICHELLE S. SCOTT ◽  
PATRICE PERRON ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
First Trimester ◽  
Second Trimester ◽  
First Trimester Of Pregnancy ◽  
Plasma Mirnas

scholarly journals Distribution of diandric and digynic triploidy depending on gestational age

2021 ◽  
Author(s):  
Diana Massalska ◽  
Katarzyna Ozdarska ◽  
Tomasz Roszkowski ◽  
Julia Bijok ◽  
Anna Kucińska-Chahwan ◽  
...  
Keyword(s):  
Gestational Age ◽  
Pregnancy Loss ◽  
First Trimester ◽  
Parental Origin ◽  
Second Trimester ◽  
Chain Reaction ◽  
Spontaneous Pregnancy ◽  
First Trimester Of Pregnancy ◽  
Polymerase Chain ◽  
Fluorescent Polymerase Chain Reaction

Abstract Purpose To establish the distribution of diandric and digynic triploidy depending on gestational age. Methods 107 triploid samples tested prospectively in a single genetic department during a four-year period were analyzed for parental origin of triploidy by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) (n=95) with the use of matching parental samples or by MS-MLPA (n=12), when parental samples were unavailable. Tested pregnancies were divided into three subgroups with regard to the gestational age at spontaneous pregnancy loss: <11 gestational weeks, 11–14 gestational weeks, and >14 gestational weeks. Results Diandric triploidy constituted overall 44.9% (46.5% in samples miscarried <11 gestational weeks, 64.3% in samples miscarried between 11 and 14 gestational weeks, and 27.8% in pregnancies which survived >14 gestational weeks). Conclusions The distribution of diandric and digynic triploidy depends on gestational age. The majority of diandric triploid pregnancies is lost in the first trimester of pregnancy. In the second trimester, diandric cases are at least twice less frequent than digynic ones.

scholarly journals Prenatal Detection of Fetal Anomalies at the 11- to 13-Week Scan—Part I: Brain, Face and Neck

2013 ◽  
Vol 7 (4) ◽  
pp. 359-368 ◽  
Author(s):  
Tamara Illescas ◽  
Waldo Sepulveda ◽  
Begona Adiego ◽  
Pilar Martinez-Ten
Keyword(s):  
Fetal Brain ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Ultrasound Screening ◽  
Second Trimester ◽  
Fetal Anomalies ◽  
Prenatal Detection ◽  
Ultrasound Findings ◽  
First Trimester Of Pregnancy ◽  
Structural Anomalies

ABSTRACT In the last 20 years, the role of first-trimester ultrasound screening has expanded from individual calculation of the risk of aneuploidy through measurement of the nuchal translucency to a powerful technique to evaluate important aspects of the fetal anatomy. Traditionally, the full anatomy scan for detection of structural anomalies has been performed in the second trimester of pregnancy. However, with the implementation of the first-trimester scan at 11 to 13 weeks of gestation many of the structural anomalies traditionally detected in the second trimester can now be identified earlier in pregnancy. In the first part of this review we discuss the main ultrasound findings that may facilitate the prenatal detection of fetal brain, face and neck abnormalities in the first trimester of pregnancy. How to cite this article Sepulveda W, Illescas T, Adiego B, Martinez-Ten P. Prenatal Detection of Fetal Anomalies at the 11- to 13-Week Scan—Part I: Brain, Face and Neck. Donald School J Ultrasound Obstet Gynecol 2013;7(4):359-368.

scholarly journals Iodine nutritional status of women in their first trimester of pregnancy in Catalonia

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Maria Teresa Torres ◽  
◽  
Lidia Francés ◽  
Lluis Vila ◽  
Josep María Manresa ◽  
...  
Keyword(s):  
Nutritional Status ◽  
First Trimester ◽  
First Trimester Of Pregnancy ◽  
Status Of Women

scholarly journals A rare case of hypercalcemia-induced pancreatitis in a first trimester pregnant woman

2018 ◽  
Vol 2018 ◽  
Author(s):  
Carine Ghassan Richa ◽  
Khadija Jamal Saad ◽  
Ali Khaled Chaaban ◽  
Mohamad Souheil El Rawas
Keyword(s):  
Acute Pancreatitis ◽  
Pregnant Woman ◽  
Primary Hyperparathyroidism ◽  
Rare Case ◽  
First Trimester ◽  
List Type ◽  
Second Trimester ◽  
Adequate Treatment ◽  
Severe Hypercalcemia ◽  
First Trimester Of Pregnancy

Summary The objective of the study is to report a case of acute pancreatitis secondary to hypercalcemia induced by primary hyperparathyroidism in a pregnant woman at the end of the first trimester. The case included a 32-year-old woman who was diagnosed with acute pancreatitis and severe hypercalcemia refractory to many regimens of medical therapy in the first trimester of pregnancy. She was successfully treated with parathyroidectomy in the early second trimester with complete resolution of hypercalcemia and pancreatitis. Neonatal course was unremarkable. To our best knowledge, this is a rare case when primary hyperparathyroidism and its complications are diagnosed in the first trimester of pregnancy. In conclusion, primary hyperparathyroidism is a rare life-threatening condition to the fetus and mother especially when associated with complications such as pancreatitis. Early therapeutic intervention is important to reduce the morbidity and mortality. Parathyroidectomy performed in the second trimester can be the only solution. Learning points: Learning how to make diagnosis of primary hyperparathyroidism in a woman during the first trimester of pregnancy. Understanding the complications of hypercalcemia and be aware of the high mortality and sequelae in both fetus and mother. Providing the adequate treatment in such complicated cases with coordinated care between endocrinologists and obstetricians to ensure optimal outcomes.

scholarly journals Echogenic intracardiac focus – existence in the first trimester and the role of microRNAs

Folia Medica ◽  
2021 ◽  
Vol 63 (1) ◽  
pp. 142-147
Author(s):  
Antonios Koutras ◽  
Zacharias Fasoulakis ◽  
Arzou Halil ◽  
Emmanuel N. Kontomanolis
Keyword(s):  
Trisomy 21 ◽  
Fetal Heart ◽  
First Trimester ◽  
Papillary Muscles ◽  
Ultrasound Scan ◽  
Second Trimester ◽  
Ultrasound Study ◽  
First Trimester Of Pregnancy ◽  
Low Sensitivity

Echogenic intracardiac focus (EIF) constitutes a finding in the ultrasound study that indicates an area which is echogenically bright in the fetal heart and is as bright as the bone that moves synchronically to the atrioventricular valves. Microcalcifications of the papillary muscles or chordae tendinae are being represented by this echogenicity and are mostly present in the left ventricle (90% of cases). EIF appears usually at the ultrasound that is realized in the mid-trimester in a percentage that reaches 3.5% in euploid fetuses and 15% to 30% in fetuses with trisomy 21. In the current paper, the rare and curious case of a 21-year-old primigravida woman is described, who presented for ultrasound scan at the 12th week of gestation. The scan revealed the presence of EIF, which is very rare, as it is well-known that it usually appears in the second trimester of pregnancy. Counseling and debriefing for dismissing parents&rsquo; anxiety is necessary as well as further examinations, because EIF has low sensitivity. This specific case report could constitute a beginning in the research of whether investigating EIF in the first trimester of pregnancy is possible and which are the benefits of its detection for the mother, the fetus and the whole family, in clinical practice.

scholarly journals Identification ofToxoplasma gondiiantigens associated with different types of infection by serum antibody profiling

Parasitology ◽  
2015 ◽  
Vol 142 (6) ◽  
pp. 827-838 ◽  
Author(s):  
JIIN FELGNER ◽  
SILVIA JUAREZ ◽  
CHRIS HUNG ◽  
LI LIANG ◽  
AARTI JAIN ◽  
...  
Keyword(s):  
Serum Antibody ◽  
First Trimester ◽  
Protein Microarrays ◽  
Recombinant Antigens ◽  
Different Types ◽  
Exon 1 ◽  
First Trimester Of Pregnancy ◽  
Antibody Profiling ◽  
Acute Toxoplasmosis ◽  
Late Stages

SUMMARYAcquisition of acute toxoplasmosis during the first trimester of pregnancy can have catastrophic consequences for the foetus. Diagnosis is routinely based on the detection of maternalToxoplasma gondii– antibodies using whole parasite extracts as detection antigen. While such assays are sensitive, they show no specificity for the stage of infection. We hypothesized diagnosis might be improved using recombinant antigens for detection, particularly if antibodies to certain antigen(s) were associated with early or late stages of infection. To address this, protein microarrays comprising 1513T. gondiiexon products were probed with well-characterized sera from seronegative (‘N’) controls, and acute (‘A’), chronic/IgM-persisting (‘C/M’) and chronic (‘C’) toxoplasmosis cases from Turkey. Three reactive exon products recognized preferentially in A infections, and three recognized preferentially in C/M infections, were expressed inEscherichia coliand tested for discrimination in IgG ELISAs. The best discriminators were exon 1 of TGME49_086450 (GRA5) which detected C/M infections with 70·6% sensitivity and 81·8% specificity, and exon 6 of TGME49_095700 (ubiquitin transferase domain-containing protein) which detected A infections with 84·8% sensitivity and 82·4% specificity. Overall, the data support a recombinant protein approach for the development of improved serodiagnostic tests for toxoplasmosis.

scholarly journals Parathyroidectomy in First Trimester of Pregnancy

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Sonia G Sharma ◽  
Steven N Levine ◽  
Rajini K Yatavelli ◽  
Manish A Shaha ◽  
Cherie Ann O Nathan
Keyword(s):  
Primary Hyperparathyroidism ◽  
Gestational Age ◽  
First Trimester ◽  
Optimal Time ◽  
Evidence Based ◽  
Second Trimester ◽  
Extreme Degree ◽  
First Trimester Of Pregnancy ◽  
Evidence Based Guidelines ◽  
Asymptomatic Disease

Abstract Primary hyperparathyroidism is not commonly diagnosed during pregnancy. For pregnant women with mild, asymptomatic disease, surgery can be avoided unless the degree of hypercalcemia becomes more severe or they develop complications. However, there are no evidence-based guidelines to assist clinicians regarding the management of primary hyperparathyroidism during pregnancy. When surgery is deemed necessary during pregnancy, the second trimester is generally considered to be the optimal time. We report the case of a 31-year-old female G1P0 who presented at 6 weeks gestation with symptoms of nausea, vomiting, polyuria, and corrected calcium of 14.8 mg/dL. Due to the extreme degree of hypercalcemia and refractory to medical treatment, it was decided that surgery could not be delayed until the second trimester. At 7w3d gestational age the patient had resection of a 37 gram, 5 × 4 × 3 cm right inferior parathyroid adenoma.

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