Long-term clinical observation. viral hepatitis B: from diagnosis to treatment selection in different periods of illness

Therapy for viral hepatitis B at the present stage depends on the stage of the disease, activity of the viral process, the extent of liver tissue fibrosis and concomitant pathological processes. The high level of liver cells fibrosis in combination with viral processes are known to promote the formation of hepatocellular carcinoma. Under our supervision over 5 years there is the patient with HBV infection and high levels of fibrosis: from the acute period ofdiseases till now. Performing long-term antiviral therapy allowed to significantly reduce the level offibrosis, however, despite the prolonged use of modern antivirals, we have twice watched ”viral breakthrough”, that necessitated stopping treatment.