scholarly journals COMBINED ANTIVIRAL THERAPY OF HEPATITIS C ASSOCIATED WITH VIRAL HEPATITIS B AND MULTIPLE SOMATIC DISEASES IN PATIENTS WITH BURDENED ONCOLOGICAL HISTORY

2017 ◽  
Vol 22 (1) ◽  
pp. 31-35
Author(s):  
V. B Poluektova ◽  
E. V Volchkova

Patients underwent many surgical interventions are referred to a high risk group on morbidity by viral hepatitis. Mixt replications of viruses of hepatitis В (VHB) and С occur rarely. Obstetricians and gynaecologists fail to recommend the implementation of IVF procedure for women with the burdened gynaecological history due to viral hepatitis В and С and the pronounced fibrosis of liver tissue. We showed that for such patients antiviral therapy (AVT) started in good time allows to stop the replication of virus of hepatitis C, considerably to decline the VHВ loading and diminish the activity of process of fibrogenesis that, consequently, gives a chance for performance of IVF procedure.

2018 ◽  
Vol 19 (2) ◽  
pp. 80-83 ◽  
Author(s):  
Hoda Alhamoudi ◽  
Nawras Alhalabi ◽  
Mouhammed Zein ◽  
Nazir Ibrahim

2019 ◽  
Vol 101-B (6) ◽  
pp. 667-674 ◽  
Author(s):  
R. Schwarzkopf ◽  
D. Novikov ◽  
A. A. Anoushiravani ◽  
J. E. Feng ◽  
J. Vigdorchik ◽  
...  

Aims With an ageing population of patients who are infected with hepatitis C virus (HCV), the demand for total knee arthroplasty (TKA) in this high-risk group continues to grow. It has previously been shown that HCV infection predisposes to poor outcomes following TKA. However, there is little information about the outcome of TKA in patients with HCV who have been treated successfully. The purpose of this study was to compare the outcomes of TKA in untreated HCV patients and those with HCV who have been successfully treated and have a serologically confirmed remission. Patients and Methods A retrospective review of all patients diagnosed with HCV who underwent primary TKA between November 2011 and April 2018 was conducted. HCV patients were divided into two groups: 1) those whose HCV was cured (HCV-C); and 2) those in whom it was untreated (HCV-UT). All variables including demographics, HCV infection characteristics, surgical details, and postoperative medical and surgical outcomes were evaluated. There were 64 patients (70 TKAs) in the HCV-C group and 63 patients (71 TKAs) in the HCV-UT cohort. The mean age at the time of surgery was 63.0 years (sd 7.5; 44 to 79) in the HCV-C group and 61.7 years (sd 6.9; 47 to 88) in the HCV-UT group. Results HCV-UT patients had a significantly longer mean hospital stay (3.4 days vs 2.9 days; p = 0.04), were more likely to be transferred to the intensive care unit (14.1% vs 4.3%; p = 0.04), and were significantly more often discharged to a post-acute care facility (39.4% vs 14.3%; p < 0.01). HCV-UT patients had significantly more postoperative infections (15.5% vs 4.3%; p = 0.03), surgical complications (21.1% vs 7.1%; p = 0.02), and revision TKA (12.7% vs 1.4%; p < 0.01) than HCV-C patients. Conclusion The preoperative treatment of HCV can reduce the risk of complications, including prosthetic joint infection and revision TKA. We recommend that HCV treatment regimens should be integrated into the preoperative optimization protocol for this high-risk group of patients. Cite this article: Bone Joint J 2019;101-B:667–674.


2008 ◽  
Vol 3 (4) ◽  
pp. 161-161
Author(s):  
A.H. Omar ◽  
K. Ashawesh

1991 ◽  
Vol 26 (S3) ◽  
pp. 176-178 ◽  
Author(s):  
Termchai Chainuvati ◽  
Y. Poovorawan ◽  
P. Luengrojanakul

2018 ◽  
Vol 12 (02.1) ◽  
pp. 28S
Author(s):  
Mary Nakhoul ◽  
Carine Richa ◽  
Afif Jreij ◽  
Antoine Abou Rached

Introduction: Injection drug users (IVDU) are prone to many blood born viral infections. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) constitute an important public health concern in this high-risk group. The aim of the study is to calculate the prevalence of hepatitis B and C viruses among people who inject drugs (PWID) in Lebanon. Methodology: We conducted a prospective cross-sectional study between June 2015 and June 2016 on PWIDs recruited through the Lebanese non-governmental organizations in collaboration with the Lebanese ministry of public health. The participants were tested for HBs Antigen and HCV antibody using rapid test kits. The prevalence of each virus was then calculated. The correlation between both infections and other possible risk factors was also analyzed. Results: A total of 250 people were included in our study. 98% were males. Mean age was 31.9-year-old. The prevalence of HBV and HCV among PWID was 1.2% and 15.6%, respectively. Older age, longer duration of drug use, and the lack of awareness were found to be significantly correlated with higher rate of HCV infection. We noted a relatively high rate of sharing needles among PWIDs without significantly affecting the prevalence of both viruses. Conclusion: IVDU remains a major public health concern in Lebanon, being one of the most prevalent subpopulations for chronic viral hepatitis namely the HCV. Appropriate screening strategies, targeted educational programs and adequate HBV vaccination are of extreme importance for further viral prevention among this high-risk group.


2014 ◽  
Vol 4 ◽  
pp. S8
Author(s):  
Provash Sadhukhan ◽  
Kallol Saha ◽  
Rushna Firdaus ◽  
Aritra Biswas ◽  
Anirban Mukherjee

2008 ◽  
Vol 3 (4) ◽  
pp. 161-161
Author(s):  
AH Omar ◽  
K Ashawesh

2019 ◽  
Author(s):  
Xiaojun Zhan ◽  
Chandala Chitguppi ◽  
Ethan Berman ◽  
Gurston Nyquist ◽  
Tomas Garzon-Muvdi ◽  
...  

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