On the question of missed abortion

2021 ◽  
Vol 20 (6) ◽  
pp. 615-621
Author(s):  
A. I. Timofeeva

As you know, according to the proposal of Oldhanf and Mattews Dunean, the terms missed labor and missed abortion are defined as cases where, after the onset and again terminated manifestations of childbirth (resp. Abortion), the fetal egg that has died in the uterine cavity is delayed for a considerable time, sometimes even longer than the normal period pregnancy.

2018 ◽  
Vol 13 (1) ◽  
pp. 51-53
Author(s):  
Shreesiya Pokhrel ◽  
Ganesh Dangal ◽  
Aruna Karki ◽  
Hema Kumari Pradhan ◽  
Ranjana Shrestha ◽  
...  

The ectopic implantation is implantation of fertilized ovum outside the uterine cavity, ampulla of fallopian tube being the most common site. A cornual or interstitial pregnancy is an ectopic pregnancy that develops in the interstitial portion of the fallopian tube which is one of the most hazardous type of ectopic gestation. Treatment depends on the week of gestation at the time of diagnosis, level of serum β HCG, findings of ultrasonography, hemodynamic stability of the patient and the choice of future fertility. In this case report, we present a case which was previously misdiagnosed as a case of missed abortion at 8 weeks of gestation by transabdominal ultrasound and patient underwent medical abortion with  mefipristione and  misoprostolandafter 1 month presented with pain abdomen and was confirmed as extrauterine pregnancy by transabdominal ultrasound followed by surgical management.


2017 ◽  
Vol 71 (1) ◽  
pp. 72-74
Author(s):  
Snezana Georgieva ◽  
Tanja Nikolova ◽  
Natasha Nikolova

Abstract We present a case of a twenty-four-year old, nulligravid woman with suspicionof molar pregnancy and admittedat the University Clinic of Obstetrics and Gynecology in Skopje. On bimanual examination uniformly enlarged uterus was detected. Ultrasonography revealed snow storm echo signal in the uterine cavity. Dilation and curettage were performed and only a slight quantity of material was obtained. Serum bHCG was negative. MRI revealed a finding of the tumorous formation on the anterior wall of the uterus deforming and dislocating the uterus without any additional information. Open surgery was planned and tumorectomy was performedinour hospital. Histopathology analysis of the obtained material revealed symplastic myoma of the uterus. The patient got spontaneously pregnant later, but the pregnancy finished as a spontaneous missed abortion and instrumental revision was performed. Five months later the patient got pregnant again. She had regular pregnancy course and delivery at 37.5 gestational week.


1926 ◽  
Vol 22 (5-6) ◽  
pp. 649-653
Author(s):  
N. N. Chukalov

If for the pathological phenomenon known as missed labor, the definition first given by Oldham and Clixton has remained in science to this day, namely, this name means that pathological state of uterine pregnancy when, at mature or almost In a mature fetus, contractions occurring at the time of labor do not lead to labor, the fetus dies and the dead remains in the uterus (after the termination of contractions) for longer than the normal period, the concept of missed abortion still suffers from inaccuracy.


2021 ◽  
Vol 12 (1) ◽  
pp. 62-67
Author(s):  
E. Y. Lebedenko ◽  
A. P. Milovanov ◽  
N. V. Sablina ◽  
T. V. Fokina ◽  
O. V. Gaida

Objective. The study aimed to compare the level of INF a2 immunoexpression in tissues obtained during medical abortion with the corresponding level of IFNa2 expression in a retained fetal egg tissues after the first missed abortion. The authors compared the anamnestic data on previous inflammatory diseases of the genital tract with the results of an extended morphological study of the material obtained during the evacuation of the contents of the uterine cavity during the first non-developing pregnancy in the first trimester.Materials and methods. The study included 15 patients with first-time missed abortions caused by a viral infection (6-8 weeks of pregnancy). All patients demonstrated either recurrent herpes simplex labialis/genitalis or PCR confirmed HSV, HPV, CMV. Exclusion criteria were recurrent miscarriage, blighted ovum, endocrinopathies, male factor infertility, and other causes of miscarriage. The comparison group included 20 women of the same age that chose to undergo a medical abortion.Results. In patients from the comparison group, the main producer of IFN a2 was syncytiotrophoblast as well as maternal decidual cells in the parietal endometrium and uteroplacental area. In the main group, manifested hematogenous infection (microabscesses, vasculitis, lymphocytic and macrophage infiltration) with dystrophy and necrosis of decidual maternal cells and secondary pathological changes in the placental villi were diagnosed, which led to a significant decrease in the IFN a2 immunoexpression in all the studied cells.Conclusion. The lack of anamnestic data on previous urogenital infections does not exclude the etiological role of the inflammatory component in the genesis of non-developing pregnancy. First-time occurred pregnancy loss requires adequate postoperative interferon therapy and a thorough examination of a couple.


2021 ◽  
Author(s):  
junjun shu ◽  
ShiXin Lin ◽  
Yu Wu ◽  
Dan Gong ◽  
Xia Zou ◽  
...  

Abstract BackgroundMissed abortion is a kind of pregnancy failure caused by various reasons. The etiology is complicated, and the incidence of miscarriage is increasing in recent years. Previous studies shown microbiota contributes to multi-systemic function, whereas the relationship between microbiota and early missed abortion remains unknown. This study aimed to explore the composition of uterine microbiota in missed abortion and the potential role.MethodsWe enrolled 19 patients diagnosed with missed abortion and 12 healthy pregnant who subsequently had 6-8th week pregnant. All samples were taken from the endometrial fluid by a special disposable endometrial sampler. After samples were collected, DNA was extracted and amplified. The high-throughput next-generation sequencing (MiSeq) of the 16S rDNA V3-V4 region was used to identify the present of microbiota. The α-diversity of microbiota data was used to reflect species richness and evenness within bacterial populations, β-diversity was used to reflect the shared diversity between bacterial populations, and Nonmetric Multidimensional Scaling based on Weighted Unifrac distance. Statistical was determined by use of multiple testing, including the generalized mixed-effects model.ResultsThe microbiome sequencing (16S rDNA V3-V4 region) revealed that low abundance microbiome was detected in uterine cavity of patients with missed abortion and normal pregnancy. The diversity of intrauterine microflora in patients with missed abortion was higher than that in patients with induced abortion in normal pregnancy. There was no significant difference in alpha diversity between the two groups, but a significant difference was observed in beta diversity. PCoA moment array analysis did not show significant differences. Proteobacteria and Firmicutes in missed abortion patients were significantly more than those in normal pregnancy group.ConclusionThere are low abundance of microflora in uterine cavity of missed abortion patients, and the diversity of microflora is higher than that of normal pregnancy patients. Also, Proteobacteria and Firmicutes may be potential biological markers in missed abortion. New observations may prompt further investigations to understand the potential mechanism of microbiology on pathologic human pregnancy in the future.SubjectsMicrobiology, Molecular Biology, Gynecology and Obstetrics, missed abortion, Female Reproductive Tract,


2017 ◽  
Vol 1 (1) ◽  
pp. 28-31
Author(s):  
Meenu Agarwal ◽  
Madhuri Kashyap

ABSTRACT Intramural pregnancy, an ectopic gestation completely surrounded by the myometrium located within the uterine wall with separation from the uterine cavity, is an extremely unusual form of pregnancy. Complications resulting from intramural pregnancy include inevitable uterine rupture with resultant hemorrhage and possible hysterectomy if the diagnosis is not made early and treatment is not initiated. A patient presented with missed abortion, suction curettage was done but no placental villi were seen in the products. She had a previous history of laparoscopic myomectomy 6 months ago. A provisional diagnosis of myometrial scar pregnancy was made and was confirmed with Doppler and magnetic resonance imaging. Laparoscopic enucleation of ectopic sac was done against medical management with methotrexate. The patient conceived successfully through intracytoplasmic sperm injection for male factor and delivered twins by lower (uterine) segment cesarean section at term. How to cite this article Agarwal M, Kashyap M, Meshram S. A Case of Laparoscopically Managed Myometrial Scar Ectopic Pregnancy. Int J Gynecol Endsc 2017;1(1):28-31.


Author(s):  
A. Gonzalez Angulo ◽  
R. Berlioz ◽  
R. Aznar

Recent ultrastructural studies on endometrial tissues from women wearing copper, wire intrauterine devices have disclosed morphological evidence of impaired glycogen degradation and secretion resulting in interference with the viability of blastocysts. Reduced microapocrine secretion observed with the scanning electron microscope supports this (1). In addition, organelle modifications have been observed in the epithelial cells of these women. The changes are seen in biopsies taken in the proliferative phase of the cycle and consist of mitochondrial vacuolation and myelin figure formation. These modifications disappear in the secretory phase and therefore have been regarded as reversible (2).The aim of the present studies was to investigate surface epithelial changes as well as organelle modifications in relation to the site of contact with an IUD that releases greater amounts of copper. Endometrial tissue was obtained from the uterine cavity of four young women wearing TCu-380-A intrauterine contraceptive devices for 4-6 weeks.


Author(s):  
E.A. Kenik ◽  
T.A. Zagula ◽  
M.K. Miller ◽  
J. Bentley

The state of long-range order (LRO) and short-range order (SRO) in Ni4Mo has been a topic of interest for a considerable time (see Brooks et al.). The SRO is often referred to as 1½0 order from the apparent position of the diffuse maxima in diffraction patterns, which differs from the positions of the LRO (D1a) structure. Various studies have shown that a fully disordered state cannot be retained by quenching, as the atomic arrangements responsible for the 1½0 maxima are present at temperatures above the critical ordering temperature for LRO. Over 20 studies have attempted to identify the atomic arrangements associated with this state of order. A variety of models have been proposed, but no consensus has been reached. It has also been shown that 1 MeV electron irradiation at low temperatures (∼100 K) can produce the disordered phase in Ni4Mo. Transmission electron microscopy (TEM), atom probe field ion microscopy (APFIM), and electron irradiation disordering have been applied in the current study to further the understanding of the ordering processes in Ni4Mo.


1972 ◽  
Vol 27 (02) ◽  
pp. 263-271 ◽  
Author(s):  
I. A. Cooper ◽  
P Cochrane ◽  
B. G. Firkin ◽  
K. J. Pinkard

SummaryIt has been suggested that human platelets possess the ability to phagocytose particulate matter similar to the polymorphonuclear leukocyte. However some difference of opinion has arisen regarding this contention, particularly as differences have been demonstrated with regard to the observed metabolic changes occurring in platelets related to such a process.The experiments reported in this paper were designed to observe the aerobic and anaerobic metabolism in human platelets during and following interiorization of two different particles, viz. polystyrene latex and thorotrast. The results of these experiments show a marked difference between both types of particles with regard to observable metabolic changes despite the rapid interiorization of both types of material. Some alteration occurs in both aerobic and anaerobic metabolism a considerable time after interiorization of latex, whereas no alteration could be demonstrated after interiorization of thorotrast. It is suggested that the interiorization of particulate matter is by some process other than phagocytosis and that observed metabolic changes related to latex may be due to a release reaction.


1970 ◽  
Vol 1 (2) ◽  
pp. 34-36
Author(s):  
Mehedi Imam

In Bangladesh, demand for judicial independence in practice has been a much debated issue and the demand is fulfilled but expectation of people is not only limited to have an independent judiciary but to have an impartial system and cadre of people, which will administer justice rationally being free from fear or force. The independence of judiciary and the impartial judicial practice are related concepts, one cannot sustain without the other and here existence as well as the need of practicing impartiality is well recognized. But the art of practicing impartiality does not develop overnight as it’s related to development of one’s attitude. It takes a considerable time resulting from understanding, appreciating and acknowledging the moral values, ethics and professional responsibility. The judiciary includes Judges, Advocates mostly who are expected to demonstrate a high level of moral values and impartiality towards people seeking justice and ‘rule of law’. This is true that bench officers and clerks are also part of the process to ensure rule of law with same level of participation by the law enforcing agencies such as police. However the paper includes only those who either join judiciary as Judge/Magistrate or Advocate to explore level and extent of ethical knowledge they receive being key role players of the system. DOI: http://dx.doi.org/10.3329/bioethics.v1i2.9628 Bangladesh Journal of Bioethics 2010; 1(2): 34-36


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