scholarly journals High blood pressure

2021 ◽  
Vol 25 (11) ◽  
pp. 1232-1233
Author(s):  
S. M. Raysky
Keyword(s):  
Blood Pressure ◽  
Angina Pectoris ◽  
High Blood Pressure ◽  
Arterial Wall ◽  
Chloral Hydrate ◽  
Muscle Cells ◽  
Renal Tissue ◽  
Table Salt ◽  
Arterial Spasm

High blood pressure prof. J. Pal (Die rztliche Praxis, No. 6, 1929) divides into two main forms: acute and permanent; The first is arterial spasm, and the second is the hypertensive setting of the muscle cells of the arterial wall ("Die hypertonische Einstellung der Muskelzellen der Arterienwand"), in which the prearterioles and arterioles are in a tense state, functionally giving rise to blood pressure. Recent research by the author has established the fallacy of the existing opinion that any persistently high blood pressure is the result of renal tissue disease. The author distinguishes primary or essential or genuinic hypertension, which, however, can lead to a shriveled kidney. Therapeutically, acute increases in blood pressure are most effectively eliminated by chloral hydrate, heat and bloodletting, and in angina pectoris - atropine, papaverine, nitrites. The author recommends treating constant increases in blood pressure with theobromine and its various combinations, bearing in mind that theobromine dilates the vessels of the heart, kidneys and brain. Balneotherapy measures are often psychogenically beneficial. The food of such patients should be poor in purines and table salt.

Renal–adrenal interrelationships in experimental hypertension

1968 ◽  
Vol 46 (2) ◽  
pp. 179-188 ◽  
Author(s):  
D. Ostrovsky ◽  
F. R. Papsin ◽  
A. G. Gornall
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Renal Artery ◽  
High Blood Pressure ◽  
Salt Intake ◽  
Renal Tissue ◽  
Experimental Hypertension ◽  
Normal Blood Pressure ◽  
Renal Hypertrophy ◽  
High Salt Intake

For several weeks after partial constriction of one renal artery, the fate of this "clipped" kidney seems to exert a determining influence on blood pressure. Rats that remained hypertensive throughout the experiment almost invariably had clipped kidneys averaging 0.16 to 0.22% of body weight. Below 0.1%, this kidney was usually quite atrophic, and its presence was consistent with falling or normal blood pressure. The untouched kidney in such rats was, on the average, heavier in the hypertensive than in the normotensive animals. Since the latter also had less renal tissue on the clipped side, it appears that factors leading to high blood pressure stimulated hypertrophy beyond the level provoked by renoprival factors. In rats on a high salt intake, 5 μg/day of D-aldosterone for 3 months stimulated significant true renal hypertrophy in the absence of a rise in blood pressure. Such hypertrophy was more pronounced in similar rats that had been getting 250 μg DOCA/day for 3 months but were also normotensive. Rats that developed hypertension on this latter regimen had still heavier kidneys. Renal hypertrophy appears to be a prehypertensive phenomenon which persists and can become even more pronounced in hypertension. The highest levels of renal hypertrophy were usually associated with significant adrenal hypertrophy. Endocrine functions may be involved in renal hypertrophy. This concept is discussed in relation to a phospholipid "renin inhibitor" recently isolated from dog and hog kidneys.

scholarly journals High blood pressure associates with the remodelling of inward rectifier K+channels in mice mesenteric vascular smooth muscle cells

2012 ◽  
Vol 590 (23) ◽  
pp. 6075-6091 ◽  
Author(s):  
Sendoa Tajada ◽  
Pilar Cidad ◽  
Alejandro Moreno-Domínguez ◽  
M. Teresa Pérez-García ◽  
José R. López-López
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
High Blood Pressure ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inward Rectifier ◽  
K Channels

scholarly journals Mechanical programming of arterial smooth muscle cells in health and ageing

2021 ◽  
Author(s):  
Robert T. Johnson ◽  
Reesha Solanki ◽  
Derek T. Warren
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Arterial Wall ◽  
Arterial Compliance ◽  
Muscle Cells ◽  
Mechanical Forces ◽  
Arterial Smooth Muscle ◽  
Mechanical Environment ◽  
Arterial Smooth Muscle Cells

AbstractArterial smooth muscle cells (ASMCs), the predominant cell type within the arterial wall, detect and respond to external mechanical forces. These forces can be derived from blood flow (i.e. pressure and stretch) or from the supporting extracellular matrix (i.e. stiffness and topography). The healthy arterial wall is elastic, allowing the artery to change shape in response to changes in blood pressure, a property known as arterial compliance. As we age, the mechanical forces applied to ASMCs change; blood pressure and arterial wall rigidity increase and result in a reduction in arterial compliance. These changes in mechanical environment enhance ASMC contractility and promote disease-associated changes in ASMC phenotype. For mechanical stimuli to programme ASMCs, forces must influence the cell’s load-bearing apparatus, the cytoskeleton. Comprised of an interconnected network of actin filaments, microtubules and intermediate filaments, each cytoskeletal component has distinct mechanical properties that enable ASMCs to respond to changes within the mechanical environment whilst maintaining cell integrity. In this review, we discuss how mechanically driven cytoskeletal reorganisation programmes ASMC function and phenotypic switching.

scholarly journals Therapy for patients with high blood pressure

2021 ◽  
Vol 25 (11) ◽  
pp. 1233-1233
Author(s):  
S. M. Raysky
Keyword(s):  
Blood Pressure ◽  
Angina Pectoris ◽  
High Blood Pressure ◽  
Dietary Salt

E. Zak (Die rztliche Praxis, No. 7, 1929) attaches great importance to mental influences and therefore suggests doctors to be careful in the sense of using terms such as "arteriosclerosis" or "angina pectoris" in front of some patients. Further, making the division of high blood pressure into two groups (stable and labile), the author proposes the following measures: for stable high blood pressure, caffeine in powder or in the form of coffee (for headaches), warns against pyramidon on a lean stomach and recommends well sometimes acting Aleuthan (Pyramiden + papaverin). The food of such patients should be poor in proteins, meat, spices and NaCl. Instead of NaCl, the author proposes a dietary salt (Dit-Salz, consisting of 1-2 g. NaCl and 2-4 g. KCl).

Living Well to Keep Your Pressure Down

EDIS ◽  
2017 ◽  
Vol 2017 (6) ◽  
Author(s):  
Linda B. Bobroff
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Blood Vessels ◽  
High Blood Pressure ◽  
Health Problems ◽  
Fact Sheet ◽  
Living Well ◽  
Heart Work ◽  
Major Revision ◽  
Reduce Risk

High blood pressure, or hypertension, can cause serious health problems. It makes your heart work harder and can damage your blood vessels even if you feel okay. Everyone should have their blood pressure checked regularly. If you have certain risk factors, you are more likely to have high blood pressure. This 6-page fact sheet is a major revision that discusses risk factors and ways to reduce risk.

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