scholarly journals State of vegetative neurous system and nonspecitic adaptation mechanisms in multiple sclerosis patients

2003 ◽  
Vol XXXV (1-2) ◽  
pp. 22-25
Author(s):  
O. V. Evdokimova ◽  
A. S. Starikov ◽  
M. M. Lapkin ◽  
V. A. Zhdanov
Keyword(s):  
Multiple Sclerosis ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Course Of Disease ◽  
Adaptation Mechanisms ◽  
Adaptive Mechanisms ◽  
Different Types ◽  
Sympathetic Nervous ◽  
Multiple Sclerosis Patients

80 multiple sclerosis patients underwent mathematic analysis of heart rate variability. It has been determined that multiple sclerosis patients are characterized by increase of the activity of the sympathetic nervous system, nonspecific adaptive mechanisms and by decrease of the adaptive organism reserves correlated with the severity of the diseases. It has been revealed that there is connection between the above parameters and different types of the course of disease.

Effect of fingolimod on cardiac autonomic regulation in patients with multiple sclerosis

2015 ◽  
Vol 22 (8) ◽  
pp. 1080-1085 ◽  
Author(s):  
Sakari Simula ◽  
Tomi Laitinen ◽  
Tiina M Laitinen ◽  
Tuula Tarkiainen ◽  
Päivi Hartikainen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Frequency Ratio ◽  
Low Frequency ◽  
Autonomic Regulation ◽  
Rr Interval ◽  
Cardiac Autonomic Regulation ◽  
Multiple Sclerosis Patients

Background: Fingolimod modulates sphingosine-1-phosphate receptors that are also found in cardiovascular tissue. Objective: To investigate the effects of fingolimod on cardiac autonomic regulation prospectively. Methods: Twenty-seven relapsing–remitting multiple sclerosis patients underwent 24-hour electrocardiogram recording before, at the first day of fingolimod treatment (1d) and after three months of continuous dosing (3mo). The time interval between two consecutive R-peaks (RR-interval) was measured. Cardiac autonomic regulation was assessed by the various parameters of heart rate variability. Parasympathetic stimulation prolongs the RR-interval and increases heart rate variability while the effects of sympathetic stimulation are mainly the opposite. The low frequency/high frequency ratio reflects sympathovagal balance. Results: From baseline to 1d, a prolongation of the RR-interval ( P<0.001), an increase in the values of various heart rate variability parameters ( P<0.05 to P<0.001) and a decrease in the low frequency/high frequency ratio ( P<0.05) were demonstrated. At 3mo, although the RR-interval remained longer ( P<0.01), the values of various heart rate variability parameters were lower ( P<0.01 to P<0.001) as compared to baseline. At 3mo, the low frequency/high frequency ratio ( P<0.05) was higher in men than in women although no such difference was found at baseline or at 1d. Conclusions: After an initial increase in parasympathetic regulation, continuous fingolimod dosing shifts cardiac autonomic regulation towards sympathetic predominance, especially in men. Careful follow-up of fingolimod-treated relapsing–remitting multiple sclerosis patients is warranted as sympathetic predominance associates generally with impaired outcome. ClinicalTrials.cov: NCT01704183

Changes in the sympathetic nervous system induced by 42 days of head-down bed rest

1998 ◽  
Vol 274 (6) ◽  
pp. H1875-H1884 ◽  
Author(s):  
Dominique Sigaudo ◽  
Jacques-Olivier Fortrat ◽  
Anne-Marie Allevard ◽  
Alain Maillet ◽  
Jean-Marie Cottet-Emard ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Baroreflex Sensitivity ◽  
Bed Rest ◽  
Urinary Catecholamines ◽  
System Activity ◽  
Nervous System Activity ◽  
Sympathetic Nervous

Changes in autonomic nervous system activity could be linked to the orthostatic intolerance (OI) that individuals suffer after a spaceflight or head-down bed rest (HDBR). We examined this possibility by assessing the sympathetic nervous system activity during 42 days of HDBR in seven healthy men. Heart rate variability was studied with the use of power spectral analysis, which provided indicators of the sympathetic (SNSi) and parasympathetic (PNSi) nervous system influences on the heart. Urinary catecholamines and the spontaneous baroreflex sensitivity were measured. Urinary catecholamines decreased by 21.3%, showing a decrease in SNSi. Heart rate variability was greatly reduced during 42 days of HDBR with a drop in PNSi but with no significant changes in SNSi. The baroreflex sensitivity was greatly reduced (30.7%) on day 42 of HDBR. These results suggest a dissociation between the catecholamine response and the SNSi of the heart rate. This dissociation could be the consequence of an increase in β-adrenergic receptor density and/or activity induced by a decrease in catecholamines during HDBR. The subjects who suffered from OI also had a greater sympathetic response and much lower baroreflex sensitivity when supine than those who finished the stand test. However, the mean response of all subjects indicated that the sympathetic activity (catecholamine excretion) was probably slightly inhibited during HDBR and could contribute to OI.

scholarly journals HEART RATE VARIABILITY OF STUDENTS WITH DIFFERENT PROFILES OF MOTOR DOMINATION DURING EXAM

2017 ◽  
Vol 18 (3.1) ◽  
pp. 203-209
Author(s):  
A.I. Lukina
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Activity Coefficient ◽  
Spectral Power ◽  
Regulatory Mechanisms ◽  
Wave Parameters ◽  
Increasing Trend ◽  
Heart Rate Fluctuations ◽  
Sympathetic Nervous

It is established hat changing of parameters of student’s electrocardiogram during the exam are shown by shortening of the intervals RR, QT, PQ, and the complex QRS, thus expressiveness of reactions dominates in sample of lefthanders and ambidexters. The values of wave parameters of heart rate variability, including spectral power of heart rate fluctuations in different frequency ranges, increase in left-handers, while ambidexterity and right handed down. The values of statistical indices of HRV, including SDNN, RMSSD and mode cardio intervals in students during the exam are reduced, and also to a greater extent, and ambidexterity for lefties. These changes corresponded to increasing trend of the index and the activity coefficient Baevsky sympathetic nervous system, indicating a greater intensity of regulatory mechanisms in individuals with left profile of motor domination.

scholarly journals Heart rate variability in laparoscopic hysterectomy depending on different types of anesthesia

2021 ◽  
Vol 3 ◽  
pp. 37-40
Author(s):  
S. Zaychenko ◽  
R. Tkachenko
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Laparoscopic Hysterectomy ◽  
Control Group ◽  
Autonomic Nervous ◽  
Stress Protection ◽  
Different Types

The objective: was to evaluate the effectiveness of various anesthesia options for laparoscopic hysterectomy, including low-opioid (LOA) and opioid-free anesthesia (OFA) by studying the dynamics of heart rate variability (HRV) indicators.Materials and methods. 102 patients were randomly assigned to 3 groups: 37 patients who received standard opioid anesthesia (control group), 33 women who received the LOA group, and 32 patients who received OFA.Results. Laparoscopic hysterectomy is accompanied by tension of the autonomic nervous system, especially its sympathetic link, which is manifested by an increase in the index of vago-sympathetic interaction at the traumatic stage of the operation. These changes were most significant in patients who received standard and opioid-free anesthesia, which indirectly indicates insufficient stress protection of these types of intraoperative anesthesia.Conclusions. The use of low-opioid anesthesia is accompanied by a greater stabilization of HRV indices, which indicates its sufficient autonomic protection during laparoscopic hysterectomy than standard and opioid-free anesthesia.

scholarly journals CHARACTERIZATION OF HEART RATE VARIABILITY DURING TOTAL VENOUS ANESTHESIA: A CASE REPORT

2018 ◽  
Vol 2 (4) ◽  
pp. 57-70
Author(s):  
Danielly Gonçalves Sombra Lima ◽  
Ageu De Oliveira Saraiva ◽  
Cicera Yolanda Dos Santos ◽  
Sebastião Messias Ribeiro Oliveira ◽  
Rafael Pires Pereira ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Poincaré Plot ◽  
Nonlinear Methods ◽  
Future Studies ◽  
The Awakening ◽  
Sympathetic Nervous ◽  
The Moment

The aim of the study was to characterize the heart rate variability in a patient with no comorbidities, submitted to buccomaxillofacial surgery under total venous anesthesia using the linear frequency and nonlinear methods in the chaos domain (Poincaré plot). Data collection was performed before, during and after the surgical procedure using a Polar V800 cardiofrequencymeter and subsequently analyzed and filtered using the Kumbios HRV 3.0 software. During propofol infusion, elevations in LF, HF, SD1 and SD2 were observed. The LF/HF ratio showed obvious changes, which were found to be maximal during extubation and submaximal during awakening under greater influence of the sympathetic nervous system. The moment of the incision has parameters similar to those of rest. Final surgery maintenance showed the lowest values of LH/HF and SD1/SD2, with lower LF and SD2 values compared to rest. During the awakening, there was a decrease in SD1 and HF, representing the moment of greatest fragility during the total venous anesthesia, being of fundamental importance future studies about their repercussions.  

scholarly journals INFLUENCE OF ANTIARRHYTHMIC DRUGS ON THE SPECTRAL ANALYSIS OF HEART RATE VARIABILITY IN PATIENTS WITH ATRIAL FIBRILLATION

2018 ◽  
Vol 21 (1-2) ◽  
pp. 101-104
Author(s):  
Ekaterina P. Popova ◽  
O. T Bogova ◽  
S. N Puzin ◽  
I. S Matsokin ◽  
A. A Gadzhimagomedova ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Spectral Analysis ◽  
Antiarrhythmic Drugs ◽  
Spectral Indices ◽  
Heart Activity ◽  
Class Iii ◽  
Sympathetic Nervous

The use of the spectral analysis of the heart rate variability to assess the effectiveness of therapy is of great attention of researchers and doctors. This method allows you to get knowledge of the influence of the autonomic nervous system on the heart activity, which is an important factor for the manifestation of the effects of antiarrhythmic drugs. In this study, we studied the effect of antiarrhythmic drugs of class III amiodarone and sotalol on spectral indices of the heart rate variability in patients with atrial fibrillation. The power of slow frequencies prevailed in the structure of the spectrum with the introduction of amiodarone and sotalol. This suggests that the sympathetic nervous system have a predominant influence on the heart.

scholarly journals Changes in Short-Term and Ultra-Short Term Heart Rate, Respiratory Rate, and Time-Domain Heart Rate Variability Parameters during Sympathetic Nervous System Activity Stimulation in Elite Modern Pentathlonists—A Pilot Study

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1104
Author(s):  
Jakub S. Gąsior ◽  
Bartosz Hoffmann ◽  
Luiz Eduardo Virgilio Silva ◽  
Łukasz Małek ◽  
Andrew A. Flatt ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Time Domain ◽  
Endurance Athletes ◽  
Sympathetic Nervous System Activity ◽  
Short Term ◽  
Nervous System Activity ◽  
Sympathetic Nervous

Monitoring of markers reflecting cardiac autonomic activity before and during stressful situations may be useful for identifying the physiological state of an athlete and may have medical or performance implications. The study aimed to determine group and individual changes in short-term (5 min) and ultra-short-term (1 min) heart rate (HR), respiratory rate (RespRate), and time-domain heart rate variability (HRV) parameters during sympathetic nervous system activity (SNSa) stimulation among professional endurance athletes. Electrocardiographic recordings were performed in stable measurement conditions (Baseline) and during SNSa stimulation via isometric handgrip in 12 elite modern pentathlonists. Significant increases in short-term HR and decreases in time-domain HRV parameters with no changes in RespRate were observed during SNSa stimulation. Significant differences were observed between Baseline (all minutes) and the last (i.e., 5th) minute of SNSa stimulation for ultra-short-term parameters. Analysis of intra-individual changes revealed some heterogeneity in responses. The study provides baseline responses of HR, RespRate, and time-domain HRV parameters to SNSa stimulation among elite pentathlonists, which may be useful for identifying abnormal responses among fatigued or injured (e.g., concussed) athletes. More attention to individual analysis seems to be necessary when assessing physiological responses to sympathetic stimuli in professional endurance athletes.

Sign in / Sign up

Export Citation Format

Share Document