scholarly journals The effects of goutweed (Aegopodium Podagraria L.) preparations and their combinations with metformin in rats with the disorders of the lipid and carbohydrate metabolism induced by protamine sulphate

2017 ◽  
Vol 15 (2) ◽  
pp. 31-41 ◽  
Author(s):  
Tatiana V Gorbatch ◽  
Sergei Y Shtrygol’ ◽  
Maria V Mishchenko ◽  
Svetlana I Stepanova ◽  
Andrei V Taran
Keyword(s):  
Lipid Metabolism ◽  
Blood Plasma ◽  
Carbohydrate Metabolism ◽  
Lipid Composition ◽  
Model Development ◽  
Atherogenic Diet ◽  
Protamine Sulfate ◽  
Protamine Sulphate ◽  
The Metabolic Syndrome ◽  
Combined Use

The improvement of the therapy of the metabolic syndrome, obesity, and type 2 diabetes is an important task which may be realized through the co-administration of herbal and synthetic medicines. The tincture and extract obtained from the aerial part of goutweed (Aegopodium podagraria L.) have been shown to possess antidiabetic and organoprotective properties. Goutweed tincture exerts a permissive effect on the action of metformin in dexamethasone-treated diabetic rats. Aim. The objective of this study is to determine the efficacy of the combined use of goutweed tincture and extract with metformin on the model of the primary disorder of the lipid metabolism. Materials and Methods. The model was used that presupposed administration of protamine sulfate to rats (10 mg/kg per day intramuscularly) against the background of atherogenic diet with the additional administration of cholestrol. Goutweed extract and tincture (1 g/kg and 1 ml/kg intragastrically, respectively), metformin (50 mg/kg intragastrically) and their combinations were administered during the whole period of model development. The lipid composition of the liver and blood plasma, as well as the content of glycogen in the liver were studied, and, as this model is accompanied with insulin resistance, glucose tolerance test was carried out. Results. It has been shown that all studied drugs and their combinations normalize the lipid composition of the liver, reducing the content of cholesterol and triglycerides and increasing the level of phospholipids. They do not significantly influence on the lipid spectrum of the blood plasma, tend to elevate the level of liver glycogen, their efficacy does not change in combined use. Goutweed tincture and metformin in combination, but not per se, completely normalize area under glucose curve that is significantly increased in the untreated group, the extract does not change this value. Conclusions. Goutweed extract and tincture normalize the lipid composition of the liver in rats with lipid and carbohydrate metabolism disorders caused by protamine sulfate and atherogenic diet, the tincture also exerts a permissive effect on the action of metformin on glucose metabolism, but not on lipid metabolism. (For citation: Tovchiga OV, Gorbatch TV, Shtrygol’ SYu, et al. The effects of goutweed (Aegopodium podagraria L.) preparations and their combinations with metformin in rats with the disorders of the lipid and carbohydrate metabolism induced by protamine sulphate. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(2):31-41. doi: 10.17816/RCF15231-41).

scholarly journals Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat

2006 ◽  
Vol 91 (11) ◽  
pp. 4287-4294 ◽  
Author(s):  
Tania S. Burgert ◽  
Sara E. Taksali ◽  
James Dziura ◽  
T. Robin Goodman ◽  
Catherine W. Yeckel ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Visceral Fat ◽  
Resonance Imaging ◽  
Fat Accumulation ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome ◽  
Hepatic Fat ◽  
Fat Fraction

Abstract Background: Concurrent with the rise in obesity, nonalcoholic fatty liver disease is recognized as the leading cause of serum aminotransferase elevations in obese youth. Nevertheless, the complete metabolic phenotype associated with abnormalities in biomarkers of liver injury and intrahepatic fat accumulation remains to be established. Methods: In a multiethnic cohort of 392 obese adolescents, alanine aminotransferase (ALT) levels were related with parameters of insulin sensitivity, glucose, and lipid metabolism as well as adipocytokines and biomarkers of inflammation. A subset of 72 adolescents had determination of abdominal fat partitioning and intrahepatic fat accumulation using magnetic resonance imaging. Findings: Elevated ALT (>35 U/liter) was found in 14% of adolescents, with a predominance of male gender and white/Hispanic race/ethnicity. After adjusting for potential confounders, rising ALT was associated with reduced insulin sensitivity and glucose tolerance as well as rising free fatty acids and triglycerides. Worsening of glucose and lipid metabolism was already evident as ALT levels rose into the upper half of the normal range (18–35 U/liter). When hepatic fat fraction was assessed using fast magnetic resonance imaging, 32% of subjects had an increased hepatic fat fraction, which was associated with decreased insulin sensitivity and adiponectin, and increased triglycerides, visceral fat, and deep to superficial sc fat ratio. The prevalence of the metabolic syndrome was significantly greater in those with fatty liver. Interpretation: Deterioration in glucose and lipid metabolism is associated even with modest ALT elevations. Hepatic fat accumulation in childhood obesity is strongly associated with the triad of insulin resistance, increased visceral fat, and hypoadiponectinemia. Hence, hepatic steatosis may be a core feature of the metabolic syndrome.

Effects of feeding ryegrass of varying maturity on the metabolism and composition of lipids in the rumen of sheep

1986 ◽  
Vol 106 (3) ◽  
pp. 445-448 ◽  
Author(s):  
T. Gerson ◽  
A. John ◽  
A. S. D. King
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Linoleic Acid ◽  
Blood Plasma ◽  
Polyunsaturated Fatty Acid ◽  
Perennial Ryegrass ◽  
Crude Protein ◽  
Linseed Oil ◽  
Triacyl Glycerol

SummaryTwo experiments were carried out to test the effects of ryegrass maturity on rumen lipid metabolism. In the first experiment the effect of stage of maturity of perennial ryegrass on lipid metabolism in the rumen was studied with grazing sheep fitted with rumen cannulae. The pasture was either immature (13·8% crude protein), mature (8·1% crude protein) or senescent (5·5% crude protein).The ratesin vitroof triacyl glycerol lipolysis and linoleic acid (18: 2w6) hydrogenation were found to decrease with increasing age of the ryegrass.In the second experiment the sheep were dosed with emulsified linseed oil (30 g) via rumen cannulae while grazing immature or senescent ryegrass and the rumen digesta and blood plasma sampled at 0, 4 and 8 h after dosing.The proportions of linseed oil retained in the rumen were greater and blood plasma linoleic (18:2w6) and linolenic (18:3w3) acid concentrations higher when senescent ryegrass was fed.It was concluded that the rates of rumen lipolysis and hydrogenation decreased with the age of pasture and that after dosing with linseed oil the polyunsaturated fatty acid concentrations in blood plasma increased.

scholarly journals Supplementation with green tea extract affects lipid metabolism and egg yolk lipid composition in laying hens

2019 ◽  
Vol 28 (4) ◽  
pp. 881-891 ◽  
Author(s):  
Jinbao Huang ◽  
Qing Hao ◽  
Qiushi Wang ◽  
Yijun Wang ◽  
Xiaochun Wan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Green Tea ◽  
Lipid Composition ◽  
Laying Hens ◽  
Egg Yolk ◽  
Green Tea Extract ◽  
Yolk Lipid ◽  
Tea Extract

Effect of probucol on the lipid composition of blood plasma, erythrocyte ghosts and liver membranes in mice

1990 ◽  
Vol 22 (9) ◽  
pp. 1009-1013 ◽  
Author(s):  
T.T. Markovska ◽  
T.N. Neicheva ◽  
A.B. Momchilova-Pankova ◽  
K.S. Koumanov ◽  
R. Infante
Keyword(s):  
Blood Plasma ◽  
Lipid Composition ◽  
Erythrocyte Ghosts ◽  
Liver Membranes

Prepubertal Children Exposed to Maternal Gestational Diabetes Have Latent Low-Grade Inflammation

2018 ◽  
Vol 90 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Leena Antikainen ◽  
Jarmo Jääskeläinen ◽  
Henrikki Nordman ◽  
Raimo Voutilainen ◽  
Hanna Huopio
Keyword(s):  
Blood Pressure ◽  
Lipid Metabolism ◽  
Gestational Diabetes ◽  
Low Grade ◽  
Prepubertal Children ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Hs Crp ◽  
Low Grade Inflammation

Background: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children’s height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. Methods: A cohort of 135 prepubertal Caucasian children (age range 4.4–9.7 years) was studied in a controlled cross-sectional study. Seventy-seven children had been exposed to maternal GDM, and 58 children born after a normal pregnancy served as controls. The outcomes were height, weight, BMI, blood pressure, and biochemical markers of glucose and lipid metabolism and inflammation. Results: There were no differences in height, weight, BMI, fasting serum insulin, plasma glucose, lipids, or blood pressure between the study groups. However, high-sensitivity C-reactive protein (hs-CRP) was significantly higher in the GDM group than in the controls (p = 0.001). Conclusions: Higher hs-CRP as a marker of low-grade inflammation was detected in prepubertal children exposed to maternal GDM, but no differences were seen in height, weight, BMI, or markers of glucose and lipid metabolism compared to control children. This finding may reflect an ongoing process of metabolic changes in children born after a GDM pregnancy.

THE LIPID COMPOSITION OF THE GUINEA PIG PLACENTA

1936 ◽  
Vol 14b (5) ◽  
pp. 155-159 ◽  
Author(s):  
Eldon M. Boyd
Keyword(s):  
Lipid Metabolism ◽  
Guinea Pig ◽  
Lipid Composition ◽  
Guinea Pigs ◽  
Free Cholesterol ◽  
Gradual Change ◽  
Cholesterol Esters ◽  
Guinea Pig Placenta ◽  
Pig Placenta ◽  
Duration Of Pregnancy

The lipid composition of the guinea pig placenta was found to vary with the duration of pregnancy. Between the 20th and the 40th days there occurred an increase in phospholipid and free cholesterol, both of which remained elevated from then on to term. There was no significant change at any time in the amount of cholesterol esters, but that of neutral fat increased steadily sixfold and more during pregnancy. These changes were interpreted as signifying a gradual change in placental lipid metabolism during pregnancy. The relation of this change to the transfer of lipids from mother to fetus, and its relation to the etiology of the lipemia of pregnancy in guinea pigs, are discussed.

scholarly journals Effect of a putative anti-atherosclerotic agent (S-8921) on lipid metabolism in mice fed an atherogenic diet

1998 ◽  
Vol 76 ◽  
pp. 228
Author(s):  
Yu Yamaguchi ◽  
Satomi Kagota ◽  
Kazuki Nakamura ◽  
Masaru Kunitomo
Keyword(s):  
Lipid Metabolism ◽  
Atherogenic Diet
Sign in / Sign up

Export Citation Format

Share Document