scholarly journals Potentiation of the hypoxic preconditioning effect by antihypoxants

2019 ◽  
Vol 17 (1) ◽  
pp. 37-44
Author(s):  
Vasiliy E. Novikov ◽  
Olga S. Levchenkova ◽  
Elena I. Klimkina ◽  
Konstantin N. Kulagin
Keyword(s):  
Hypobaric Hypoxia ◽  
Carotid Arteries ◽  
Acute Hypoxia ◽  
Hypoxia Inducible Factor ◽  
Experimental Models ◽  
Hypoxic Preconditioning ◽  
Acute Hypobaric Hypoxia ◽  
Hypoxia With Hypercapnia ◽  
The Common ◽  
Common Carotid Arteries

The development of effective methods to increase the organism resistance to hypoxia is an important task of current medicine. One of such methods is preconditioning, as a result of which, a potent mobilization of the adaptive organism abilities occurs under a preconditioning factor action. Aim. To study the possibility of potentiating of the hypoxic preconditioning effect with help of antihypoxants. Methods. Evaluation of the effectiveness of combined preconditioning (antihypoxants + moderate hypobaric hypoxia) was performed on experimental models of acute hypoxia with hypercapnia, acute hypobaric hypoxia in mice, and bilateral occlusion of the common carotid arteries in rats. Investigated antihypoxants are amtizol, hypoxen, cobazole, metaprot, mexidol, mildronate, substances under the codes VM-606, pQ-4 and pQ-1104. Results. PreC with use of amtizol at dose 25 mg/kg, cobazole at dose 30 mg/kg, VM-606, pQ-4 and pQ-1104 at doses 50 mg/kg in combination with moderate hypoxia increased the lifespan of mice in acute hypoxia with hypercapniamodel and acute hypobaric hypoxia from 57 to 170%. Combined preconditioning with amtizol, cobazole and pQ-4 significantly increased the survival rate of rats in cerebral ischemia, amtizol and pQ-4 reduced neurological deficiency in the post ischemic period as well. Conclusion. Antitipoxants as amtizol, cobazole, VM-606, pQ-4, pQ-1104 potentiate the hypoxic preconditioning effect on acute hypoxia with hypercapnia, acute hypobaric hypoxia and occlusion of the common carotid arteries models, the most significant effect was noted for amtizol and pQ-4. Signal role in the adaptation induction to hypoxia and ischemia by combined preconditioning with use of antihypoxants hypoxia-inducible factor HIF-1α can play.

scholarly journals THE COMPARATIVE STUDYING OF ANTI-HYPOXEMIC ACTIVITY OF COMPLEX OF ZINC ACETATE WITH N-PROPARGYLIMIDAZOLE AND 3-HYDROXYPYRIDINE

2017 ◽  
Vol 23 (3) ◽  
pp. 148-151
Author(s):  
S. A Shakhmardanova ◽  
P. A Galenko-Yaroshevsky ◽  
L. N Parshina ◽  
B. A Trofimov ◽  
V. V Tarasov ◽  
...  
Keyword(s):  
Zinc Acetate ◽  
Hypobaric Hypoxia ◽  
Large Range ◽  
Narrow Range ◽  
Acute Hypoxia ◽  
Comparative Investigation ◽  
Complex Compounds ◽  
Control Groups ◽  
Acute Hypobaric Hypoxia ◽  
Hypoxia With Hypercapnia

The pharmacotherapy of hypoxia is an important task of modern experimental and clinical pharmacology. The medications with anti-hypoxic effect implemented into clinical practice unfortunately do not meet requirements of physicians due to poor efficiency, narrow range of active dosages and undesirable side effects. The complexes of zinc with N-alkenylimidazole demonstrated anti-hypoxic activity at various models of acute hypoxia within large range of dosage. Therefore, further studying of zinc-contained compounds as possible correctors of hypoxia is of particular interest. The experiments with white nonlinear male mice were used for comparative investigation of ant-hypoxic effect of complex compounds of zinc acetate with N-propargylimidazole and 3-hydroxipyridine, including complexes immobilized on sulfated arabinogalaсtan and also well-known anti-hypoxants and/or anti-oxidants: etomerzol, mexidol, nooglutil and hypoxen. It is demonstrated that anti-hypoxic effect of complex of zinc acetate with N-propargylimidazolein conditions of acute hypobaric hypoxia, acute hypoxia with hypercapnia acute hematic hypoxia by width of active dosages (1-100 mg/kg, intraperitoneally) and degree of expression (19-317% in comparison with control groups of animals) excels the similar effect in well-known anti-hypoxants and/or anti-oxidants: etomerzol (25-100 mg/kg, intraperitoneally), mexidol (100 mk per kg, intraperitoneally), nooglutil (25-100 mg/kg, intraperitoneally) and hypoxen (50-150 mg/kg, intraperitoneally). The protective effect of complex of zinc acetate with 3-hydroxipyridine by width of active dosages (25-100 mg/kg, intraperitoneally) and degree of expression (27-167% in comparison with control groups of animals) in conditions of exogenous hypoxia (acute hypobaric hypoxia and acute hypoxia with hypercapnia) excels similar effect of etomerzol and mexidol ans is comparable with effect of nooglutil and hypoxen. The complexes immobilized on sulfated arabinogalactan were ineffective.

scholarly journals Bilateral Displacement of the Common Carotid Arteries by a Large Goiter

Cureus ◽  
2018 ◽  
Author(s):  
Lexian J McBain ◽  
Joe Iwanaga ◽  
Rod J Oskouian ◽  
Marios Loukas ◽  
R. Shane Tubbs
Keyword(s):  
Carotid Arteries ◽  
Large Goiter ◽  
The Common ◽  
Common Carotid Arteries

Abstract P433: Emerging Lifestyle Factors Predict Carotid Intimal Media Thickness Scores

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Steven C Masley ◽  
Richard Roetzheim ◽  
Timothy P McNamara ◽  
Lucas V Masley ◽  
Douglas D Schocken
Keyword(s):  
Cardiovascular Risk ◽  
Linear Regression ◽  
Aerobic Fitness ◽  
Carotid Arteries ◽  
Multivariate Analyses ◽  
Lifestyle Factors ◽  
Carotid Imt ◽  
The Common ◽  
Common Carotid Arteries ◽  
Statin Use

Introduction: Cardiovascular disease (CVD) remains the number one cause of mortality in the western world. Carotid intimal media thickness (carotid IMT) is a safe and reliable predictor of future CVD risk. Hypothesis: The study aims to assess the hypothesis that lifestyle factors impact carotid IMT, and determine which nutrition and fitness risk factors best predict mean carotid IMT scores. Methods: A prospective cross-sectional analysis of 592 men and women undergoing health and cardiovascular risk screening. This study reflects the first visit of these subjects, age 23 to 65 (mean = 48.2), who are followed longitudinally and who were participants at a “wellness” oriented program for patients who are generally well-educated and mostly in good health. Measurements were made of fitness using VO2max stress testing and push-up and sit-up scores following the American College of Sports Medicine testing protocols, diet intake using a 3-day dietary intake survey and computerized analyses. Mean carotid IMT scores were obtained using high resolution B-mode ultrasonography of the common carotid arteries. Each subject had ≥10 images collected from the far wall of the right and left distal 1 cm of the common carotid arteries at end diastole. The carotid intimal thickness was measured as a continuous variable, using both multivariate linear and bivariate linear regression. Multivariate analyses adjusted for potential confounders using multiple linear regression and included measures of body composition, blood pressure, fasting lipid and glucose levels, and statin use. Results: Multivariate analyses show that higher mean carotid IMT values are associated with increasing age (p<0.0001), male gender (p<.0.0001), lower aerobic capacity (p=0.0045), lower intake of fish (p=0.05), and lower intake of zinc (p=0.0002). Bivariate analyses controlling for age and gender, with and without statin use, showed higher mean carotid IMT scores were statistically associated with lower levels of aerobic fitness, (p = 0.0007), lower intake of fiber (p=0.02) and lower intake of magnesium (p=0.019). Intake of protein, carbohydrate, and fat as percent of calories; as well as intake of saturated fat, sodium, calcium, potassium, and vitamin K; measures of strength (assessed with push-up and sit-up testing); and self-reported exercise minutes per week were not associated with mean carotid IMT scores. Conclusions: In this database, aerobic fitness and dietary intake of fiber, fish, magnesium, and zinc are associated with lower carotid IMT scores. Further studies are warranted to explore the impact of emerging lifestyle factors on cardiovascular risk and clinical outcomes.

Doppler Assessment of the Effect of Chewing Qat on Hemodynamics of the Common Carotid Arteries

2017 ◽  
Vol 17 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Mohamed Ibrahim ◽  
Bushra Hussein A. Malik ◽  
Moawia Gameraddin
Keyword(s):  
Carotid Arteries ◽  
The Common ◽  
Common Carotid Arteries

Secondary Flow in the Human Common Carotid Artery Imaged by MR Angiography

1992 ◽  
Vol 114 (1) ◽  
pp. 147-149 ◽  
Author(s):  
C. G. Caro ◽  
C. L. Dumoulin ◽  
J. M. R. Graham ◽  
K. H. Parker ◽  
S. P. Souza
Keyword(s):  
Human Subject ◽  
Mr Angiography ◽  
Carotid Arteries ◽  
Three Dimensional ◽  
Flow Imaging ◽  
Dynamic Flow ◽  
Healthy Human Subject ◽  
Healthy Human ◽  
The Common ◽  
Common Carotid Arteries

The blood flow in arteries affects both the biology of the vessels and the development of atherosclerosis. The flow is three dimensional, unsteady, and difficult to measure or to model computationally. We have used phase-shift-based magnetic resonance angiography to image and measure the flow in the common carotid arteries of a healthy human subject. There was curvature of the vessels and thin-slice dynamic flow imaging showed evidence of the presence of secondary motions. Flexing the cervical spine straightened the vessels and reduced the asymmetry of the flow.

Vascular Doppler ultrasonographic indices in cirrhosis: a case–control study with emphasis on the common carotid arteries

2015 ◽  
Vol 120 (10) ◽  
pp. 982-988
Author(s):  
Abolhassan Shakeri ◽  
Mojtaba Varshochi ◽  
Naser Atapour ◽  
Masoud Nemati ◽  
Manoochehr Khoshbaten ◽  
...  
Keyword(s):  
Carotid Arteries ◽  
Case Control Study ◽  
Case Control ◽  
The Common ◽  
Common Carotid Arteries ◽  
Control Study

scholarly journals Dependence of the efficiency of the initial state of fosinopril structure common carotid arteries, intravascular blood flow and central hemodynamics at patients with arterial hypertension

2015 ◽  
Vol 12 (3) ◽  
pp. 30-33
Author(s):  
L V Melnikova ◽  
L F Bartosh ◽  
O A Grechishkina
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Carotid Arteries ◽  
Peak Flow ◽  
Peripheral Resistance ◽  
Initial State ◽  
Central Hemodynamic ◽  
Functional Features ◽  
The Common ◽  
Common Carotid Arteries

Aim. To study changes in structural and functional features of the common carotid arteries and central hemodynamic parameters under the influence of fosinopril at hypertensive patients depending on achieving target blood pressure.Material and methods. The study included 116 patients with essential hypertension. All patients underwent a general clinical study, an ultrasound scan of the common carotid arteries (CCA ) with the assessment of the structure and intravascular blood flow, and echocardiography with the definition of the parameters of central hemodynamic and intravascular, ambulatory blood pressure monitoring (ABPM) before the study and after 24 weeks of antihypertensive therapy angiotensin - converting enzyme fosinopril. Two groups of patients: the first group consisted of 74 people with the achievement of the targets of blood pressure (BP), the second 42 people who have not been achieved target BP levels.Results. In the first group there was a statistically significant decrease in the proportion of peripheral resistance, increased systolic index, distensibility coefficient of the common carotid arteries peak flow velocity. In the second group specific peripheral resistance was significantly increased, the thickness of the intima-media increased, decreased peak flow velocity.Conclusion. Effectiveness depends on fosinopril initial state total peripheral resistance, cardiac output, structural and functional features elastic arteries.

scholarly journals Intima-media thickness of the common carotid arteries as a marker of retinopathy and nephropathy in sickle cell disease

2020 ◽  
Vol 39 (1) ◽  
pp. 79-84
Author(s):  
Oluwagbemiga O. Ayoola ◽  
Rahman A. Bolarinwa ◽  
Oluwatoyin H. Onakpoya ◽  
Stephen O. Onigbinde ◽  
Christianah M. Asaleye ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Cell Disease ◽  
Media Thickness ◽  
The Common ◽  
Common Carotid Arteries
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